{"orpha":247257,"name":"Inhalational anthrax","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Inhalation anthrax disease","Pulmonary anthrax","Respiratory anthrax","Respiratory anthrax disease"],"definition":"Inhalational anthrax is a rare acute systemic infection caused by the inhalation of <i>Bacillus anthracis</i> spores (e.g. through infected animal products, bioterrorism) and characterized by an initial stage where patients present with non specific symptoms (fever, cough, chills, fatigue) that is followed by an acute phase during which hemorrhagic mediastinitis occurs that can progress into meningitis, gastrointestinal involvement, and refractory shock, that can be fatal, if left untreated.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-247257/","orphanet_url":"https://www.orpha.net/en/disease/detail/247257","names":{"fr":{"name":"Charbon pulmonaire","synonyms":["Maladie du charbon, forme respiratoire","Maladie du charbon, forme par inhalation"],"definition":"Infection systémique aiguë rare causée par l'inhalation de spores de <i>Bacillus anthracis</i> (par exemple, par le biais de produits animaux infectés, de bioterrorisme) et caractérisée par une phase initiale au cours de laquelle les patients présentent des symptômes non spécifiques (fièvre, toux, frissons, fatigue), suivie d'une phase aiguë caractérisée par la survenue d'une médiastinite hémorragique pouvant évoluer vers une méningite, une atteinte gastro-intestinale et un choc réfractaire, et pouvant causer le décès en l'absence de traitement."},"de":{"name":"Anthrax durch Inhalation","synonyms":["Lungenmilzbrand"],"definition":"Der inhalative Milzbrand ist eine seltene akute systemische Infektion, die durch das Einatmen von Bacillus anthracis-Sporen (z.B. durch infizierte tierische Produkte, Bioterrorismus) verursacht wird. Im Anfangsstadium treten bei Patienten unspezifische Symptome (Fieber, Husten, Schüttelfrost, Müdigkeit) auf, gefolgt von einer akuten Phase, in der eine hämorrhagische Mediastinitis auftritt, die in eine Meningitis, gastrointestinale Beteiligung und refraktären Schock übergehen kann, die unbehandelt tödlich sein können."},"es":{"name":"Enfermedad por inhalación de ántrax","synonyms":["Enfermedad respiratoria por inhalación de ántrax"],"definition":"Es una infección sistémica aguda poco frecuente causada por la inhalación de esporas de <i>Bacillus anthracis</i> (por ejemplo, a través de productos animales infectados, bioterrorismo) y caracterizada por una etapa inicial en la que los pacientes presentan síntomas inespecíficos (fiebre, tos, escalofríos, cansancio) seguida de una fase aguda durante la cual ocurre una mediastinitis hemorrágica que puede progresar a meningitis, compromiso gastrointestinal y shock refractario, que puede resultar fatal si no se trata."},"it":{"name":"Malattia da inalazione di antrace","synonyms":["Malattia respiratoria da antrace"]},"nl":{"name":"Inhalatie-anthrax","synonyms":["Inhalatie-anthraxziekte","Pulmonale anthrax","Respiratoire anthrax","Respiratoire anthraxziekte"],"definition":"Inhalatie-anthrax is een zeldzame acute systemische infectie die veroorzaakt wordt door het inademen van <i>Bacillus anthracis</i>-sporen (bvb. door besmette dierlijke producten, bioterrorisme) en die gekenmerkt wordt door een initiële fase waarin patiënten niet-specifieke symptomen (koorts, hoest, rillingen, vermoeidheid) vertonen, gevolgd door een acute fase waarin hemorragische mediastinitis voorkomt die kan evolueren tot meningitis, gastro-intestinale betrokkenheid en refractaire shock, die fataal kan zijn zonder behandeling."},"pt":{"name":"Doença por inalação de antrax"},"pl":{"name":"Wąglik płucny","synonyms":["Wąglik oddechowy","Wąglik płucny"]},"cs":{"name":"Inhalační antrax","synonyms":["Plicní antrax","Respirační antrax"]},"uk":{"name":"Інгаляційна сибірська виразка","synonyms":["Інгаляційна форма сибірської виразки","Легенева форма сибірської виразки","Респіраторна сибірська виразка","Респіраторна форма сибірської виразки"],"definition":"Inhalational anthrax is a rare acute systemic infection caused by the inhalation of <i>Bacillus anthracis</i> spores (e.g. through infected animal products, bioterrorism) and characterized by an initial stage where patients present with non specific symptoms (fever, cough, chills, fatigue) that is followed by an acute phase during which hemorrhagic mediastinitis occurs that can progress into meningitis, gastrointestinal involvement, and refractory shock, that can be fatal, if left untreated."},"zh":{"name":"吸入性炭疽病","synonyms":["吸入性炭疽病"],"definition":"吸入性炭疽是一种罕见的急性全身感染，由吸入炭疽杆菌孢子（例如，通过受感染的动物制品、生物恐怖主义）所致，其特征是患者出现非特异性症状（发烧、咳嗽、寒战，疲劳），而后进入急性期，表现为出血性纵隔炎，可进展为脑膜炎、胃肠道受累和顽固性休克，若不治疗可致命。"},"tr":{"name":"Solunum yoluyla alınan şarbon","synonyms":["Pulmoner şarbon","Solunum şarbonu","İnhalasyon şarbon hastalığı","Solunum şarbon hastalığı"]}},"xrefs":[{"source":"ICD-10","code":"A22.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1B97","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"534877374"},{"source":"MONDO","code":"0016595","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C571912","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0155866","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10035667","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2018[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2017-04-03","source":"10559102[PMID]_12396910[PMID]","terms":[{"hpo":"HP:0000971","label":"Abnormality of the sweat gland","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011159","label":"Epigastric auras","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002615","label":"Hypotension","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002546","label":"Incomprehensible speech","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011029","label":"Internal hemorrhage","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100806","label":"Sepsis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002013","label":"Vomiting","frequency":"Frequent (79-30%)","criteria":null}]}}