{"orpha":2459,"name":"Mansonelliasis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Mansonellosis"],"definition":"A form of filariasis, distributed throughout sub-Saharan Africa as well as in some locations of Central and South America and the Caribbean, caused by the parasitic worms <i>Mansonella perstans</i> and <i>Mansonella ozzardi</i>. The disease is often asymptomatic but may also cause fever, vertigo, myalgias, arthralgias and a sensation of coldness in the legs. Additional features include neuropsychiatric symptoms, skin rash, pruritus, nodules containing adult worms (in the conjunctiva or eyelids), lymphadenopathy, recurrent lymphedema in the limbs and face (resembling the Calabar swellings of loasis), severe abdominal pain and endocrine disturbances.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-2459/","orphanet_url":"https://www.orpha.net/en/disease/detail/2459","names":{"fr":{"name":"Mansonellose","definition":"Forme de filariose causée par les vers parasitaires <i>Mansonella perstans</i> et <i>Mansonella ozzardi</i>, distribuée en Afrique subsaharienne, et dans certaines régions d'Amérique centrale et du Sud, et les Caraïbes. La maladie est souvent asymptomatique, mais elle peut également causer une fièvre, des vertiges, des myalgies, des arthralgies et une sensation de froid aux jambes. Des manifestations neuropsychiatriques, un prurit, une éruption cutanée, des nodules contenant les vers adultes (dans la conjonctive ou les paupières), une lymphadénopathie, un lymphoedème récurrent des membres et du visage (ressemblant à l'oedème de Calabar de la loase), une douleur abdominale sévère et des troubles endocriniens peuvent être observées."},"de":{"name":"Mansonelliasis","synonyms":["Mansonellose"],"definition":"Eine Form der Filariose, die in ganz Afrika südlich der Sahara sowie an einigen Orten in Mittel- und Südamerika und der Karibik verbreitet ist und durch die parasitären Würmer <i>Mansonella perstans</i> und <i>Mansonella ozzardi</i> verursacht wird. Die Krankheit verläuft oft asymptomatisch, kann aber auch Fieber, Schwindel, Myalgien, Arthralgien und ein Kältegefühl in den Beinen verursachen. Zu den weiteren Symptomen gehören neuropsychiatrische Symptome, Hautausschlag, Juckreiz, Knötchen mit ausgewachsenen Würmern (in der Bindehaut oder den Augenlidern), Lymphadenopathie, wiederkehrende Lymphödeme in den Gliedmaßen und im Gesicht (ähnlich den Calabar-Schwellungen bei Loasis), starke Bauchschmerzen und endokrine Störungen."},"es":{"name":"Mansonelosis","synonyms":["Mansonellosis"],"definition":"Es una forma de filariasis que se distribuye a lo largo del África subsahariana y en determinadas zonas de Centroamérica y Sudamérica y el Caribe, y está causada por los gusanos parásitos <i>Mansonella perstans</i> y <i>Mansonella ozzardi</i>. La enfermedad suele ser asintomática, pero también puede causar fiebre, vértigo, mialgias, artralgias y sensación de frío en las piernas. También puede asociar síntomas neuropsiquiátricos, erupciones cutáneas, prurito, nódulos que contienen gusanos adultos (en la conjuntiva o los párpados), linfoadenopatía, edemas linfáticos recurrentes en las extremidades y el rostro (parecidos al edema de Calabar de la loasis), dolor abdominal intenso y trastornos endocrinos."},"it":{"name":"Mansonelliasi","synonyms":["Mansonellosi"],"definition":"La mansonellosi è una forma lieve di filariosi (si veda questo termine), diffusa in tutta l'Africa subsahariana e in alcune località del Centro e Sud America e nei Caraibi, causata dai vermi parassiti <i>Mansonella perstans</i> e <i>Mansonella ozzardi</i>. La malattia è spesso asintomatica, ma può anche causare febbre, vertigini, mialgie, artralgie e sensazione di freddo alle gambe. Altri segni clinici sono quelli neuropsichiatrici, le eruzioni cutanee, il prurito, i noduli contenenti i vermi adulti (nella congiuntiva o nelle palpebre), la linfoadenopatia, il linfedema ricorrente degli arti e del viso (simile all'edema di Calabar nella loiasi; si veda questo termine), i forti dolori addominali e i disturbi endocrini."},"nl":{"name":"Mansonelliasis","synonyms":["Mansonellose"],"definition":"Een vorm van filariasis, verspreid over sub-Sahara-Afrika en delen van Centraal- en Zuid-Amerika en de Caraïben, veroorzaakt door de parasitaire wormen <i>Mansonella perstans</i> en <i>Mansonella ozzardi</i>. De ziekte is vaak asymptomatisch, maar kan ook koorts, vertigo, myalgie, artralgie en een gevoel van koud zijn in de benen veroorzaken. Bijkomende kenmerken zijn onder meer neuropsychiatrische symptomen, huiduitslag, pruritus, noduli met volwassen wormen (in conjunctiva of oogleden), lymfadenopathie, recidiverend lymfoedeem in ledematen en gelaat (gelijkend op Calabar-zwelling van loiasis), ernstige abdominale pijn, en endocriene functiestoornissen."},"pt":{"name":"Mansonellose"},"pl":{"name":"Mansoneloza","synonyms":["Mansonellosis"],"definition":"Forma filariozy, występująca w Afryce Subsaharyjskiej, a także w niektórych regionach Ameryki Środkowej i Południowej oraz na Karaibach, wywoływana przez pasożytnicze robaki Mansonella perstans i Mansonella ozzardi . Choroba często przebiega bezobjawowo, ale może również powodować gorączkę, zawroty głowy, bóle mięśni i stawów oraz uczucie zimna w nogach. Dodatkowe objawy obejmują objawy neuropsychiatryczne, wysypkę skórną, świąd, guzki zawierające dorosłe robaki (w spojówce lub powiekach), powiększenie węzłów chłonnych, nawracające obrzęki limfatyczne kończyn i twarzy (przypominające opuchliznę Calabara z loasis), silne bóle brzucha i zaburzenia endokrynologiczne."},"cs":{"name":"Mansoneliáza","synonyms":["Mansonelóza"]},"uk":{"name":"Мансонельози","synonyms":["Мансонельоз"],"definition":"A form of filariasis, distributed throughout sub-Saharan Africa as well as in some locations of Central and South America and the Caribbean, caused by the parasitic worms <i>Mansonella perstans</i> and <i>Mansonella ozzardi</i>. The disease is often asymptomatic but may also cause fever, vertigo, myalgias, arthralgias and a sensation of coldness in the legs. Additional features include neuropsychiatric symptoms, skin rash, pruritus, nodules containing adult worms (in the conjunctiva or eyelids), lymphadenopathy, recurrent lymphedema in the limbs and face (resembling the Calabar swellings of loasis), severe abdominal pain and endocrine disturbances."},"zh":{"name":"曼森线虫病","synonyms":["曼森线虫病"]},"tr":{"name":"Mansonelliaz","synonyms":["Mansonelloz"]}},"xrefs":[{"source":"ICD-10","code":"B74.4","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F66.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1504434405"},{"source":"MONDO","code":"0005838","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008368","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0024759","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"8216","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10089224","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":2034,"name":"Filariasis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}