{"orpha":2404,"name":"Loiasis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Loiasis is a form of filariasis, caused by the parasitic worm <i>Loa loa</i>, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva (''African eye worm'') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-2404/","orphanet_url":"https://www.orpha.net/en/disease/detail/2404","names":{"fr":{"name":"Loase","synonyms":["Filariose à loa-loa","Loaose"],"definition":"La loase est une forme de filariose causée par le ver parasitaire <i>Loa loa</i>, endémique des régions forestières et des savanes de l'Afrique Centrale et de l'Ouest. La loase peut être asymptomatique ou se manifester par une large zone d'oedème sous-cutané non érythémateux localisé transitoire (oedème de Calabar), et la migration de vers adultes à travers la sous-conjonctive (« ver africain de l'oeil »). Un prurit généralisé, une urticaire, des myalgies, des arthralgies, une fatigue et la migration visible de vers adultes sous la surface de la peau peuvent être observés. Des complications sévères telles qu'une encéphalopathie peuvent être observées chez les patients présentant une infestation sévère recevant un traitement par ivermectine dans le cadre des programmes d'éradication de l'onchocercose et de la filariose lymphatique."},"de":{"name":"Loiasis","synonyms":["Afrikanischer Augenwurm"],"definition":"Loiasis ist eine Form der Filariose (siehe diesen Begriff), die durch den parasitären Wurm <i>Loa loa</i> verursacht wird, der in den Wald- und Savannenregionen Zentral- und Westafrikas endemisch ist. Loiasis kann entweder asymptomatisch verlaufen oder sich als großes, vorübergehendes, lokalisiertes, nicht erythematöses subkutanes Ödem (Calabar-Schwellungen), Migration adulter Würmer durch die Subkonjunktiva (,,afrikanischer Augenwurm'') und Juckreiz manifestieren. Es können allgemeiner Juckreiz, Nesselsucht, Muskelschmerzen, Gelenkschmerzen, Müdigkeit und sichtbar unter der Hautoberfläche wandernde adulte Würmer beobachtet werden. Schwere Komplikationen wie Enzephalopathie wurden bei hochgradig infizierten Personen beobachtet, die im Rahmen von Programmen zur Massenmedikation zur Bekämpfung von Onchozerkose und lymphatischer Filariose (siehe diese Begriffe) Ivermectin erhielten."},"es":{"name":"Loasis","definition":"La loasis es una forma de filariasis (véase este término) causada por el gusano parásito <i>Loa loa</i>, endémico de las regiones selváticas y de la sabana del África central y occidental. La loasis puede ser asintomática o manifestarse como una zona de edema no eritematoso subcutáneo (edema de Calabar) extensa, transitoria y localizada, migración de los gusanos adultos a través de la subconjuntiva (\"gusano africano del ojo\") y prurito. Se puede observar picor generalizado, urticaria, dolores musculares, artralgias, fatiga y gusanos adultos migrando de manera visible bajo la superficie de la piel. En individuos con alto grado de infección que reciben ivermectina en programas de administración de fármacos en masa para el control de la oncocercosis y la filasiasis linfática (véanse estos términos) se han observado graves complicaciones tales como la encefalopatía."},"it":{"name":"Loiasi","definition":"La loiasi è una forma di filariosi (si veda questo termine), causata dal verme parassita <i>Loa loa</i>, che è endemica nella savana e nelle foreste dell'Africa centrale e occidentale. La loiasi può essere asintomatica o presentarsi con un esteso edema sottocutaneo non eritematoso, localizzato e transitorio (edema di Calabar), con la migrazione dei vermi adulti sotto la congiuntiva (\"verme oculare africano\") e con il prurito. Possono essere presenti il prurito generalizzato, l'orticaria, i dolori muscolari, le artralgie, l'affaticamento, con la presenza di vermi adulti che migrano visibilmente sotto la superficie della cute. Sono state descritte complicanze gravi, come l'encefalopatia, nei pazienti maggiormente compromessi dall'infezione trattati con ivermectina, a seguito di programmi di somministrazione di massa del farmaco per il controllo dell'oncocercosi e della filariosi linfatica (si vedano questi termini)."},"nl":{"name":"Loiasis","definition":"'Loiasis is een vorm van filariasis (zie deze term), veroorzaakt door de parasitaire worm <i>Loa loa</i> die endemisch is in de bos- en savanneregio's van Centraal- en West-Afrika. Loiasis kan ofwel symptomatisch zijn, of zich manifesteren als een groot, voorbijgaand gebied van gelokaliseerd, niet-erythemateus subcutaan oedeem (calabarzwellingen), migratie van de volwassen worm door de subconjunctiva (''Afrikaanse oogworm'') en pruritus. Gegeneralizeerde jeuk, netelroos, spierpijnen, artralgieën, vermoeidheid, en volwassen wormen die zichtbaar migreren onder het huidoppervlak kunnen waargenomen worden. Ernstige complicaties zoals encefalopathie werden gerapporteerd bij erg geïnfecteerde individuen die ivermectine toegediend krijgen tijdens programma's van massale toediening van geneesmiddelen voor de controle van onchocerciase en lymfatische filariasis (zie deze termen).'"},"pt":{"name":"Loiasiose"},"pl":{"name":"Loaoza"},"cs":{"name":"Loaiáza","synonyms":["Loalóza","Loaóza"]},"uk":{"name":"Лоіазіс","definition":"Loiasis is a form of filariasis (see this term), caused by the parasitic worm <i>Loa loa</i>, endemic to the forest and savannah regions of Central and Western Africa. Loiasis may either be asymptomatic or manifest as a large, transient area of localized, non-erythematous subcutaneous edema (Calabar swellings), adult worm migration through the sub-conjunctiva (''African eye worm'') and pruritus. Generalized itching, hives, muscle pains, arthralgias, fatigue, and adult worms visibly migrating under the surface of the skin may be observed. Severe complications such as encephalopathy have been reported in highly infected individuals receiving ivermectin during mass drug administration programs for the control of onchocerciasis and lymphatic filariasis (see these terms)."},"zh":{"name":"罗阿丝虫病"},"tr":{"name":"Loiasis"}},"xrefs":[{"source":"ICD-10","code":"B74.3","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F66.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"709184369"},{"source":"MONDO","code":"0016566","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D008118","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0023968","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"3283","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10024797","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":2034,"name":"Filariasis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"22784545[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":">1 / 1000","value":0.0,"area":"Specific population","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}