{"orpha":231080,"name":"High-grade dysplasia in patients with Barrett esophagus","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-231080/","orphanet_url":"https://www.orpha.net/en/disease/detail/231080","names":{"fr":{"name":"Dysplasie de haut grade chez les patients présentant un oesophage de Barrett"},"de":{"name":"Hochgradige Dysplasie in Patienten mit Barrett-Ösophagus","synonyms":["Hochgradigen Neoplasie der Barrett-Schleimhaut"]},"es":{"name":"Displasia de grado alto en pacientes con esófago de Barrett"},"it":{"name":"Displasia di alto grado nei pazienti affetti da esofago di Barrett"},"nl":{"name":"Hooggradige dysplasie bij patiënten met Barrett-oesofagus"},"pt":{"name":"Displasia de alto grau em doentes com esófago de Barrett"},"pl":{"name":"Dysplazja wysokiego stopnia u pacjentów z przełykiem Barreta"},"cs":{"name":"Těžká dysplázie u pacientů s Barretovým jícnem"},"uk":{"name":"Дисплазія високого ступеня у пацієнтів зі стравоходом Барретта"},"zh":{"name":"患者高度发育异常伴巴雷特食管"},"tr":{"name":"Barrett özofagusu ile seyreden hastalarda yüksek dereceli displazi"}},"xrefs":[{"source":"ICD-10","code":"K22.7","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"DA23.1","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"707356537"},{"source":"UMLS","code":"C1334003","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97935,"name":"Rare gastroenterologic disease"},"parents":[{"orpha":101936,"name":"Rare gastroesophageal disease","classifications":[152]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":36.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2002[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-08-21","source":"28613697[PMID]","terms":[{"hpo":"HP:0100580","label":"Barrett esophagus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002020","label":"Gastroesophageal reflux","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005240","label":"Esophageal obstruction","frequency":"Occasional (29-5%)","criteria":null}]}}