{"orpha":230800,"name":"Toxin-mediated infectious botulism","type":"Clinical subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Toxin-mediated infective botulism"],"definition":"Infectious botulism is a form of botulism, a rare acquired neuromuscular junction disease, characterized by descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), produced <i>in vivo</i> leading to toxin-mediated infection. Infectious botulism includes wound botulism and intestinal toxemia botulism (infant botulism and adult intestinal botulism).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-230800/","orphanet_url":"https://www.orpha.net/en/disease/detail/230800","names":{"fr":{"name":"Botulisme toxi-infectieux","synonyms":["Botulisme par toxi-infection","Toxi-infection botulinique","Toxi-infection botulique"],"definition":"Le botulisme toxi-infectieux est une forme de botulisme , une maladie acquise rare de la jonction neuromusculaire avec paralysie flasque descendante due à la neurotoxine botulique (BoNT), dont la production <i>in vivo</i> provoque la toxi-infection. Le botulisme toxi-infectieux comprend le botulisme par blessure et le botulisme intestinal (botulisme infantile et botulisme intestinal de l'adulte)."},"de":{"name":"Botulismus, infektiöser","definition":"Der infektiöse Botulismus ist eine Form des Botulismus, einer seltenen erworbenen Störung der Muskelendplatte mit absteigender schlaffer Lähmung. Ursache sind im Organismus produzierte Botulinum-Neurotoxine (BoNTs) während einer toxin-vermittelten Infektion. Formen des infektiösen Botulismus sind der Wundbotulismus und der intestinale Botulismus mit Toxämie (Säuglingsbotulismus und adulter intestinaler Botulismus)."},"es":{"name":"Botulismo infeccioso por toxinas","definition":"El botulismo infeccioso por toxinas es una forma de botulismo (ver término), una enfermedad rara adquirida de la unión neuromuscular con parálisis flácida descendente causada por la neurotoxina botulínica (BoNT), cuya producción <i>in vivo</i> provoca la toxiinfección. Este tipo de botulismo incluye el botulismo por herida y el intestinal (botulismo infantil y botulismo intestinal del adulto)."},"it":{"name":"Botulismo infettivo tossina-mediato","definition":"Il botulismo infettivo è una forma di botulismo (si veda questo termine), una malattia rara acquisita delle giunzioni neuromuscolari, caratterizzata da paralisi flaccida discendente da neurotossina del botulino (BoNT), la cui produzione in vivo provoca un'infezione tossino-mediata. Il botulismo infettivo comprende il botulismo da ferita e il botulismo da tossiemia intestinale (botulismo infantile e botulismo intestinale dell'adulto; si vedano questi termini)."},"nl":{"name":"Toxinegemedieerd infectieus botulisme","definition":"Een vorm van botulisme, een zeldzame verworven aandoening van neuromusculaire overgang met afdalende slappe paralyse veroorzaakt door botuline-neurotoxinen (BoNT's), die <i>in vivo</i> worden geproduceerd en leiden tot toxinegemedieerde infectie. Infectieus botulisme omvat wondbotulisme en intestinaal toxemisch botulisme (botulisme bij zuigeling en intestinaal botulisme bij volwassene)."},"pt":{"name":"Botulismo infecioso","definition":"O botulismo infeccioso é uma forma de botulismo (ver este termo), uma doença adquirida rara da junção neuromuscular, caracterizada por paralisia flácida descendente causada por neurotoxinas botulínicas (BoNTs), produzidas <i> in vivo </ i> levando a infecção mediada por toxina. O botulismo infeccioso inclui botulismo por ferimentos e botulismo de toxemia intestinal (botulismo infantil e o botulismo intestinal do adulto; ver estes termos)."},"pl":{"name":"Botulizm zakaźny wywołany przez toksyny","synonyms":["Toxin-mediated infective botulism"]},"cs":{"name":"Infekční botulismus zprostředkovaný toxinem","synonyms":["Toxin-mediated infective botulism"]},"uk":{"name":"Інфекційний ботулізм, опосередкований токсином","synonyms":["Інфекційний ботулізм, опосередкований токсином"],"definition":"Infectious botulism is a form of botulism (see this term), a rare acquired neuromuscular junction disease, characterized by descending flaccid paralysis caused by botulinum neurotoxins (BoNTs), produced <i>in vivo</i> leading to toxin-mediated infection. Infectious botulism includes wound botulism and intestinal toxemia botulism (infant botulism and adult intestinal botulism; see these terms)."},"zh":{"name":"毒素介导的传染性肉毒中毒","synonyms":["毒素介导的传染性肉毒中毒"],"definition":"感染性肉毒中毒是一种肉毒杆菌中毒（见该词条），是一种罕见的获得性神经肌肉接头疾病，其特征是由在 体内 产生的肉毒杆菌神经毒素（BoNTs）引起的毒素介导的感染并导致下行性弛缓性麻痹。感染性肉毒中毒包括伤口肉毒中毒和肠道毒血症肉毒中毒（婴儿肉毒中毒和成人肠道肉毒中毒；见这些词条）。"},"tr":{"name":"Toksin-aracılı bulaşıcı botulizm","synonyms":["Toksin aracılı enfektif botulizm"]}},"xrefs":[{"source":"ICD-10","code":"A05.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1A11.1","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1373611689"},{"source":"MONDO","code":"0016468","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5679843","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":1267,"name":"Botulism","classifications":[181,189,203]}],"children":[{"orpha":178481,"name":"Intestinal botulism","type":"Clinical subtype"},{"orpha":178475,"name":"Wound botulism","type":"Etiological subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0100021","label":"Cerebral palsy","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002019","label":"Constipation","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006597","label":"Diaphragmatic paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011499","label":"Mydriasis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003470","label":"Paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000651","label":"Diplopia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000508","label":"Ptosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002747","label":"Respiratory insufficiency due to muscle weakness","frequency":"Frequent (79-30%)","criteria":null}]}}