{"orpha":2302,"name":"Asbestos intoxication","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Asbestosis"],"definition":"A rare pneumoconiosis caused by exposure to asbestos particles. Symptoms may appear many years after exposure and include progressive dyspnea on exertion, dry cough, chest pain, tightness, inspiratory crackles, clubbing of the fingers. Later complications include mesothelioma and lung cancers.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-2302/","orphanet_url":"https://www.orpha.net/en/disease/detail/2302","names":{"fr":{"name":"Intoxication à l'amiante","synonyms":["Asbestose"],"definition":"Pneumoconiose rare causée par l'exposition aux particules d'amiante. Les symptômes incluant une dyspnée progressive à l'effort, une toux sèche, des douleurs thoraciques, une sensation d'oppression, des râles crépitants et un hippocratisme digital, peuvent apparaître plusieurs années après l'exposition. Le mésothéliome et les cancers du poumon font partie des complications ultérieures."},"de":{"name":"Asbestintoxifikation","synonyms":["Asbestose"],"definition":"Die Asbest-Intoxikation ist eine Pneumokokniose (s. dort), verursacht durch Exposition mit Asbestpartikeln. Die Symptome (zunehmende Belastungsdyspnoe, trockener Husten, Thoraxschmerzen, Atembeklemmung, inspiratorisches Rasseln, Trommelschlegelfinger) können noch viele Jahre nach der Exposition aufftreten. Spätere Komplikationen sind Pleura-Mesotheliom und Lungenkrebs (s.diese Termini)."},"es":{"name":"Intoxicación por amianto","synonyms":["Asbestosis"],"definition":"Es una neumoconiosis causada por la exposición a partículas de asbesto. Los síntomas pueden aparecer muchos años después de la exposición e incluyen disnea progresiva al esfuerzo, tos seca, dolor torácico, opresión, crepitantes inspiratorios, hipocratismo digital. Entre las complicaciones posteriores se incluyen mesotelioma y cáncer de pulmón."},"it":{"name":"Intossicazione da asbesto","definition":"L'intossicazione da asbesto è una pneumoconiosi (si veda questo termine) causata dall'esposizione a particelle di asbesto. I sintomi possono presentarsi anni dopo l'esposizione e comprendono dispnea progressiva da sforzo, tosse secca, dolore toracico, oppressione, crepitii inspiratori, ippocratismo digitale. Le successive complicazioni comprendono il mesotelioma e il cancro polmonare (si vedano questi termini)."},"nl":{"name":"Asbestintoxicatie","synonyms":["Asbestose"],"definition":"Een zeldzame pneumoconiose veroorzaakt door blootstelling aan asbestdeeltjes. Symptomen verschijnen mogelijk pas vele jaren na blootstelling en omvatten progressieve dyspneu bij inspanning, droge hoest, pijn op de borst, drukkend gevoel op de borst, inspiratoir ademgeruis, en trommelstokvingers. Latere complicaties zijn onder meer mesothelioom en longkankers."},"pt":{"name":"Intoxicação por amianto","synonyms":["Asbestose"]},"pl":{"name":"Zatrucie azbestem","synonyms":["Pylica azbestowa"]},"cs":{"name":"Intoxikace azbestem","synonyms":["Azbestóza"]},"uk":{"name":"Азбестова інтоксикація","synonyms":["Азбестоз"],"definition":"A rare pneumoconiosis caused by exposure to asbestos particles. Symptoms may appear many years after exposure and include progressive dyspnea on exertion, dry cough, chest pain, tightness, inspiratory crackles, clubbing of the fingers. Later complications include mesothelioma and lung cancers."},"zh":{"name":"石棉中毒","synonyms":["石棉肺"]},"tr":{"name":"Asbest zehirlenmesi","synonyms":["Asbestoz"]}},"xrefs":[{"source":"ICD-10","code":"J61","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"CA60.2","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"898495881"},{"source":"MONDO","code":"0016466","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D001195","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0003949","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5852","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10003441","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97955,"name":"Rare respiratory disease"},"parents":[{"orpha":182098,"name":"Pneumoconiosis","classifications":[184,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-12-04","source":"9012357[PMID]_21281828[PMID]_30753424[PMID]","terms":[{"hpo":"HP:0006530","label":"Abnormal pulmonary interstitial morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002086","label":"Abnormality of the respiratory system","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0045051","label":"Decreased DLCO","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002207","label":"Diffuse reticular or finely nodular infiltrations","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003546","label":"Exercise intolerance","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002875","label":"Exertional dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031998","label":"Late inspiratory crackles","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031246","label":"Nonproductive cough","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030874","label":"Oxygen desaturation on exertion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031944","label":"Pleural thickening","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032341","label":"Reduced forced vital capacity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002792","label":"Reduced vital capacity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002091","label":"Restrictive ventilatory defect","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031631","label":"Subpleural honeycombing","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032016","label":"Abnormal sputum","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031352","label":"Chest tightness","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100759","label":"Clubbing of fingers","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001648","label":"Cor pulmonale","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000961","label":"Cyanosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025179","label":"Ground-glass opacification on pulmonary HRCT","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030849","label":"Hepatojugular reflux","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012418","label":"Hypoxemia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030879","label":"Interlobular septal thickening on pulmonary HRCT","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002206","label":"Pulmonary fibrosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002878","label":"Respiratory failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001708","label":"Right ventricular failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030828","label":"Wheezing","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100750","label":"Atelectasis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000969","label":"Edema","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030078","label":"Lung adenocarcinoma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100001","label":"Malignant mesothelioma","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100721","label":"Mediastinal lymphadenopathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001685","label":"Myocardial fibrosis","frequency":"Very rare (<4-1%)","criteria":null}]}}