{"orpha":2287,"name":"Fused mandibular incisors","type":"Morphological anomaly","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Fused manidbular incisors is an extremely rare dental anomaly that is characterized by the union of two, normally separated, incisor tooth germs of the primary dentition. It is frequently associated with hypodontia and an increased risk of pulp exposure.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-2287/","orphanet_url":"https://www.orpha.net/en/disease/detail/2287","names":{"fr":{"name":"Fusion des incisives mandibulaires","definition":"La fusion des incisives mandibulaires est une anomalie dentaire extrêmement rare caractérisée par la réunion de deux germes d'incisive de la dentition primaire, normalement séparés. Elle est fréquemment associée à une hypodontie et à un risque accru d'exposition de la pulpe."},"de":{"name":"Fusionierte mandibuläre Inzisoren","synonyms":["Verschmelzung der Schneidezähne im Unterkiefer"],"definition":"Fusionierte mandibuläre Inzisoren sind eine extrem seltene Zahnanomalie. Kennzeichnend ist die Vereinigung von zwei (normal getrennten) Zahnknospen des Milchgebisses. Häufig bestehen gleichzeitig eine Hypodontie (sh. dort) und ein erhöhtes Risiko für eine offene Pulpa."},"es":{"name":"Fusión de incisivos mandibulares","definition":"La fusión de incisivos mandibulares es una anomalía dental extremadamente rara que se caracteriza por la unión de los gérmenes de dos dientes incisivos de la primera dentición normalmente separados. Frecuentemente está asociado con hipodoncia (ver este término) y un mayor riesgo de exposición pulpar."},"it":{"name":"Fusione degli incisivi mandibolari","definition":"La fusione degli incisivi mandibolari è un'anomalia estremamente rara dei denti, caratterizzata dall'unione di due germi dei denti incisivi della dentizione decidua, normalmente separati. Si associa spesso ad ipodontia (si veda questo termine) e al rischio di esposizione della polpa."},"nl":{"name":"Gefuseerde mandibulaire snijtanden","definition":"Gefuseerde mandibulaire snijtanden is een uiterst zeldzame afwijking aan de tanden die wordt gekarakteriseerd door het samensmelten van twee kiemen, die normaal gezien gescheiden zijn, van snijtanden van het melkgebit. Het is vaak geassocieerd met hypodontie (zie deze term) en een verhoogd risico op blootstelling van het tandmerg."},"pt":{"name":"Fusão dos incisivos mandibulares"},"pl":{"name":"Zlane siekacze żuchwy"},"cs":{"name":"Spojené řezáky dolní čelisti"},"uk":{"name":"Зрощені різці нижньої щелепи","definition":"Fused manidbular incisors is an extremely rare dental anomaly that is characterized by the union of two, normally separated, incisor tooth germs of the primary dentition. It is frequently associated with hypodontia (see this term) and an increased risk of pulp exposure."},"zh":{"name":"下颌切牙融合"},"tr":{"name":"Kaynaşmış mandibular kesici dişler"}},"xrefs":[{"source":"OMIM","code":"147251","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"K00.2","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"LA30.4","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1109888650"},{"source":"MONDO","code":"0007820","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C3494175","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"2419","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98026,"name":"Rare odontologic disease"},"parents":[{"orpha":420755,"name":"Rare genetic odontal or periodontal disorder","classifications":[156]},{"orpha":164001,"name":"Rare odontal or periodontal disorder","classifications":[197]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adolescent","Adult","Childhood"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0000164","label":"Abnormality of the dentition","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006288","label":"Advanced eruption of teeth","frequency":"Very frequent (99-80%)","criteria":null}]}}