{"orpha":228371,"name":"Foodborne botulism","type":"Clinical subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Intoxication botulism"],"definition":"Foodborne botulism is the most common form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis due to botulinum neurotoxins (BoNTs). It is caused by consumption of contaminated food containing BoNTs.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-228371/","orphanet_url":"https://www.orpha.net/en/disease/detail/228371","names":{"fr":{"name":"Botulisme alimentaire","synonyms":["Botulisme par intoxination","Intoxination botulinique","Intoxination botulique"],"definition":"Le botulisme alimentaire est la forme la plus commune de botulisme , une maladie acquise rare de la jonction neuromusculaire avec paralysie flasque descendante due à la neurotoxine botulique (BoNT); il survient après ingestion de toxine préformée dans un aliment contaminé."},"de":{"name":"Botulismus, ernährungsbedingter","synonyms":["Botulismus, Lebensmittelbedingter"],"definition":"Der ernährungsbedingte Botulismus ist die häufigste Form des Botulismus, einer seltenen erworbenen Störung der motorischen Endplatte mit mit absteigender schlaffer Parese durch die Wirkung der Botulinum-Neurotoxine (BoNTs). Ursache ist der Verzehr kontaminierter, BoTSs enthaltender Nahrung."},"es":{"name":"Botulismo alimentario","synonyms":["Botulismo por intoxicación"],"definition":"El botulismo alimentario es la forma más frecuente de botulismo (ver término), una enfermedad rara adquirida de la unión neuromuscular con parálisis flácida descendente causada por la neurotoxina botulínica (BoNT). Está causado por el consumo de comida contaminada con BoNT."},"it":{"name":"Botulismo alimentare","synonyms":["Botulismo da intossicazione"],"definition":"Il botulismo alimentare è la forma più comune di botulismo, una rara malattia acquisita delle giunzioni neuromuscolari con paralisi flaccida discendente da neurotossina del botulino (BoNT). È causato dall'ingestione di alimenti contaminati da BoNT."},"nl":{"name":"Door voedsel veroorzaakt botulisme","synonyms":["Intoxicatiebotulisme"],"definition":"Door voedsel veroorzaakt botulisme is de meest gangbare vorm van botulisme, een zeldzame verworven aandoening van neuromusculaire overgang met afdalende slappe paralyse veroorzaakt door botuline-neurotoxinen (BoNT's). Het wordt veroorzaakt door consumptie van besmet voedsel dat BoNT's bevat."},"pt":{"name":"Botulismo com origem em produtos alimentares","definition":"O botulismo alimentar é a forma mais comum de botulismo (ver este termo), uma doença adquirida rara da junção neuromuscular com paralisia flácida descendente, devido às neurotoxinas botulínicas (BoNTs)."},"pl":{"name":"Botulizm pokarmowy","synonyms":["Zatrucie jadem kiełbasianym"]},"cs":{"name":"Potravinový botulismus","synonyms":["Intoxikační botulismus"]},"uk":{"name":"Харчовий ботулізм","synonyms":["Інтоксикаційний ботулізм"],"definition":"Foodborne botulism is the most common form of botulism (see this term), a rare acquired neuromuscular junction disease with descending flaccid paralysis due to botulinum neurotoxins (BoNTs). It is caused by consumption of contaminated food containing BoNTs."},"zh":{"name":"食源性肉毒中毒","synonyms":["肉毒中毒"],"definition":"食源性肉毒中毒是肉毒杆菌中毒的最常见形式（见该词条），是一种罕见的获得性神经肌肉接头疾病，表现为肉毒杆菌神经毒素（BoNTs）引起的下行性弛缓性麻痹。本病由食用了被BoNTs污染的食物所引发。"},"tr":{"name":"Gıda kaynaklı botulizm","synonyms":["Zehirlenme botulizmi"]}},"xrefs":[{"source":"ICD-10","code":"A05.1","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"1A11.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"2033726602"},{"source":"MONDO","code":"0016453","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1739094","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":1267,"name":"Botulism","classifications":[181,189,203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Europe","status":"Validated","source":"21495856[PMID]_[EXPERT]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"United States","status":"Validated","source":"21495856[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.18,"area":"Romania","status":"Validated","source":"21495856[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100021","label":"Cerebral palsy","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002019","label":"Constipation","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006597","label":"Diaphragmatic paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000651","label":"Diplopia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001260","label":"Dysarthria","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011499","label":"Mydriasis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003470","label":"Paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000508","label":"Ptosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000217","label":"Xerostomia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002017","label":"Nausea and vomiting","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002747","label":"Respiratory insufficiency due to muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000016","label":"Urinary retention","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006543","label":"Cardiorespiratory arrest","frequency":"Occasional (29-5%)","criteria":null}]}}