{"orpha":228312,"name":"Autoimmune hemolytic anemia, cold type","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":["cAHA","cAIHA","Cold AIHA"],"definition":"Cold autoimmune hemolytic anemia comprises two types of autoimmune hemolytic anemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30&nbsp;°C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold hemoglobinuria (PCH).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-228312/","orphanet_url":"https://www.orpha.net/en/disease/detail/228312","names":{"fr":{"name":"Anémie hémolytique auto-immune à auto-anticorps froids","synonyms":["AIHA froid","cAHA","cAIHA"],"definition":"L'anémie hémolytique auto-immune à auto-anticorps froids recouvre deux formes d'anémie hémolytique auto-immune (AHAI) définies par la présence d'auto-anticorps dits « froids », c'est-à-dire actifs à des températures inférieures à 30 °C : la maladie des agglutinines froides (MAF), qui est la plus fréquente, et l'hémoglobinurie paroxystique <i>a frigore<i> (HPF)."},"de":{"name":"Anämie, autoimmun-hämolytische, Kälte-Typ","definition":"Der Kälte-Typ der Autoimmun-hämolytischen Anämie umfasst zwei Formen von Autoimmun-hämolytischer Anämie (AIHA; s. dort) mit Anwesenheit von Kälte-Atoantikörpern (unterhalb von 30°C aktive Autoantikörper): die häufigere Kälteagglutinin-Krankheit (CAD) und die Paroxysmale Kälte-Hämoglobinurie (PCH; s. diese Termini)."},"es":{"name":"Anemia hemolítica autoinmune con autoanticuerpos fríos","synonyms":["AHAI con autoanticuerpos fríos","AIHA con autoanticuerpos fríos"],"definition":"La anemia hemolítica autoinmune con autoanticuerpos (AAC) frios comprende dos tipos de anemia hemolítica autoinmune (AIHA) definidos por la presencia de AACs fríos (activos a temperaturas inferiores a 30&#730;C): la enfermedad de las crioaglutininas (CAD), el más común, y la hemoglobinuria paroxística ``a frigore'' (PCH)."},"it":{"name":"Anemia emolitica autoimmune da autoanticorpi freddi","synonyms":["AIHA fredda","cAHA","cAIHA"],"definition":"L'anemia emolitica fredda comprende due tipi di anemia emolitica autoimmune (AIHA; si veda questo termine), caratterizzati dalla presenza di autoanticorpi freddi (autoanticorpi attivi a temperature inferiori ai 30°C): la malattia da agglutinine fredde (CAD), che è più comune, e l'emoglobinuria parossistica a frigore (PCH; si veda questo termine)."},"nl":{"name":"Auto-immune hemolytische anemie, koude-type","synonyms":["Auto-immune hemolytische anemie met koude auto-antilichamen","Koude AIHA","cAHA","cAIHA"],"definition":"Auto-immune hemolytische anemie, koude-type omvat twee types van auto-immune hemolytische anemie (AIHA), gedefinieerd door de aanwezigheid van koude auto-antilichamen (auto-antilichamen die actief zijn bij temperaturen onder 30°C), met name koude agglutinine-ziekte (CAD), die vaker voorkomt, en paroxysmale koude hemoglobinurie (PCH)."},"pt":{"name":"Anemia hemolítica autoimune, do frio","definition":"A anemia hemolítica autoimune tipo quente compreende dois tipos de anemia hemolítica auto-imune (AIHA; ver este termo) definida pela presença de auto-anticorpos frios (auto-anticorpos ativos a temperaturas inferiores a 30 &deg; C): doença por aglutininas a frio (CAD), que é a mais comum e hemoglobinúria paroxística por frio (PCH; ver estes termos)."},"pl":{"name":"Autoimmunologiczna niedokrwistość hemolityczna, typu zimnego","synonyms":["cAHA","cAIHA","Cold AIHA"]},"cs":{"name":"Chladová AIHA","synonyms":["Autoimunitní hemolytická anémie, chladový typ","cAHA","cAIHA"]},"uk":{"name":"Аутоімунна гемолітична анемія, холодний тип","synonyms":["cAHA","cAIHA","Холодний AIHA"],"definition":"Cold autoimmune hemolytic anemia comprises two types of autoimmune hemolytic anemia (AIHA; see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold hemoglobinuria (PCH; see these terms)."},"zh":{"name":"自身免疫性溶血性贫血冷型","synonyms":["AIHA冷型"],"definition":"冷抗体型自身免疫性溶血性贫血包括两种类型的自身免疫性溶血性贫血（AIHA；见该词条），其定义为存在冷抗体（最佳反应温度低于30℃的自身抗体）的冷凝集素病（CAD）（较常见）和阵发性冷血红蛋白尿症（PCH；见这些词条）。"},"tr":{"name":"Otoimmün hemolitik anemi, soğuk tip","synonyms":["cAHA","cAIHA","Soğuk AIHA"]}},"xrefs":[{"source":"ICD-11","code":"3A20.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1836938544"},{"source":"MONDO","code":"0016450","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"16450","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5848126","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10009868","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97992,"name":"Rare hematologic disease"},"parents":[{"orpha":98375,"name":"Autoimmune hemolytic anemia","classifications":[194]}],"children":[{"orpha":56425,"name":"Cold agglutinin disease","type":"Disease"},{"orpha":90035,"name":"Paroxysmal cold hemoglobinuria","type":"Disease"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 100 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}