{"orpha":228285,"name":"Acquired cutis laxa","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Cutis laxa acquisita"],"definition":"A rare disorder of the connective tissue characterized by skin inflammation inducing elastolysis, leading to sudden, progressive fine skin wrinkling, and variable systemic involvement.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-228285/","orphanet_url":"https://www.orpha.net/en/disease/detail/228285","names":{"fr":{"name":"Cutis laxa acquise","synonyms":["Cutis laxa acquisita"],"definition":"Maladie rare du tissu conjonctif caractérisée par une inflammation cutanée entraînant une élastolyse, provoquant l'apparition soudaine et progressive de fines rides cutanées, ainsi qu'une atteinte systémique variable."},"de":{"name":"Cutis laxa, erworbene","synonyms":["Cutis laxa acquisita"]},"es":{"name":"Cutis laxa adquirido","synonyms":["Cutis laxa acquisita"]},"it":{"name":"Cutis laxa acquisita"},"nl":{"name":"Verworven cutis laxa","synonyms":["Cutis laxa acquisita"],"definition":"Een zeldzame aandoening van bindweefsel, gekenmerkt door huidontsteking die elastolyse induceert, wat leidt tot plotse, progressieve fijne rimpeling van de huid, en variabele systemische betrokkenheid."},"pt":{"name":"Cutis laxa adquirida"},"pl":{"name":"Skóra wiotka nabyta","synonyms":["Cutis laxa acquisita"]},"cs":{"name":"Získaná cutis laxa","synonyms":["Cutis laxa acquisita"]},"uk":{"name":"Набута cutis laxa","synonyms":["Cutis laxa acquisita"]},"zh":{"name":"获得性皮肤松弛","synonyms":["获得性皮肤松弛"]},"tr":{"name":"Edinsel cutis laxa","synonyms":["Kutis laksa akuisita"]}},"xrefs":[{"source":"ICD-10","code":"L98.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"EE41.0","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"807277512"},{"source":"MONDO","code":"0016446","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0406549","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":89826,"name":"Rare skin disease"},"parents":[{"orpha":228221,"name":"Acquired dermis elastic tissue disorder with decreased elastic tissue","classifications":[187]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood","Elderly","Infancy"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":110.0,"area":"Worldwide","status":"Validated","source":"38924070[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}