{"orpha":228123,"name":"Coccidioidomycosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Desert rheumatism","San Joaquin valley fever","Valley fever","California disease","Coccidioides infection","Desert fever"],"definition":"Coccidioidomycosis is a fungal infection caused by <i>Coccidioides immitis</i> and <i>C. posadasii</i>, which is endemic to the Southwestern United States, Central America, South America and Mexico, and is acquired by inhalation of the infective arthroconidia, often found in soil. In most cases it is a benign, self-limiting febrile illness, but in a minority of cases it can become a potentially lethal infection of the lungs and, extremely rarely, spread to other organs (through hematogenous dissemination) with manifestations including meningitis, osteomyelitis, and skin and soft-tissue involvement.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-228123/","orphanet_url":"https://www.orpha.net/en/disease/detail/228123","names":{"fr":{"name":"Coccidioïdomycose","synonyms":["Fièvre de la vallée","Fièvre de la vallée de Californie","Fièvre de la vallée de San Joaquin","Fièvre du désert","Maladie de Californie","Rhumatisme du désert"],"definition":"La coccidioïdomycose est une infection fongique causée par <i>Coccidioides immitis</i> et <i>C. posadasii</i>, avec une présence endémique dans le Sud-Ouest des Etats-Unis, en Amérique centrale, en Amérique du sud et au Mexique, et qui se transmet par inhalation des spores infectieuses (arthroconidia) souvent présentes dans le sol. La maladie est généralement bénigne et se guérit spontanément, mais dans une minorité de cas, elle peut évoluer vers une infection pulmonaire potentiellement létale et, de manière extrêmement rare, se propager vers d'autres organes (par dissémination hématogène) avec des manifestations pouvant inclure une méningite, une ostéomyélite, et une atteinte de la peau et des tissus mous."},"de":{"name":"Kokzidioidomykose","synonyms":["Coccidioides-Infektion","Talfieber","Valley-Fieber","Wüstenfieber","Wüstenrheumatismus"],"definition":"Die Coccidioidomykose (Wüstenrheumatismus) ist eine Pilzinfektion verursacht durch <i>Coccidioides immitis</i> und <i>C. posadasii</i>, die im Südwestern der USA, Mexiko, Zentralamerika und Südamerika endemisch ist. Sie wird durch Einatmen der infektiösen Arthroconidien erworben, die sich häufig im Erdboden finden. Meistens verläuft sie als gutartige, selbstlimitierende fiebrige Erkrankung, aber in einer Minderheit der Krankheitsfälle kann sie zu einer potentiell tödlichen Lungenentzündung werden. Sehr selten betrifft sich auch andere Organe (mittels hämatogener Streuung) und äußert sich als Meningitis, Osteomyelitis sowie Auswirkungen auf die Haut und Weichteile."},"es":{"name":"Coccidioidomicosis","synonyms":["Enfermedad de California","Fiebre del Valle","Fiebre del desierto","Fiebre del valle de San Joaquín","Infección por Coccidioides","Reumatismo del desierto"],"definition":"La coccidioidomicosis es una infección fúngica causada por <i>Coccidioides immitis</i> y <i>C. posadasii</i>, endémica del sudoeste de los Estados Unidos, América Central, Sudamérica y México, y se adquiere por inhalación de artroconidia infectiva, que suele encontrarse en el suelo. En la mayoría de los casos se trata de un cuadro febril benigno autolimitante, pero en unos pocos casos se puede convertir en una infección potencialmente mortal de los pulmones y, en ocasiones extremadamente raras, se puede propagar a otros órganos (por diseminación hemática) con manifestaciones que incluyen meningitis, osteomielitis y afectación de la piel y los tejidos blandos."},"it":{"name":"Coccidioidomicosi","synonyms":["Febbre del deserto","Febbre della valle","Febbre della valle di San Joaquin","Infezione da Coccidioides","Malattia della California","Reumatismo del deserto"],"definition":"La coccidioidomicosi è un'infezione micotica causata da <i>Coccidioides immitis</i> e <i>C. posadasii</i>, endemica nell'area sud-occidentale degli Stati Uniti, nell'America Centrale, nel Sud America e in Messico, trasmessa attraverso l'inalazione di artroconidi infestanti, spesso presenti nel terreno. Nella maggior parte dei casi, si manifesta come malattia febbrile autolimitante benigna. Tuttavia, in alcuni casi, si può manifestare con un'infezione polmonare, potenzialmente letale ed estremamente rara, e diffondersi ad altri organi (attraverso la disseminazione per via ematica), con segni che comprendono la meningite, l'osteomielite e il coinvolgimento della cute e dei tessuti molli."},"nl":{"name":"Coccidioïdomycose","synonyms":["California ziekte","Coccidioïdesinfectie","San Joaquin valleikoorts","Valleikoorts","Woestijnkoorts","Woestijnreuma"],"definition":"Coccidioïdomycose is een schimmelinfectie veroorzaakt door <i>Coccidioides immitis</i> en <i>C. posadasii</i>, die endemisch is in het zuidwesten van de Verenigde Staten, Centraal-Amerika, Zuid-Amerika en Mexico, en die verworven wordt door het inademen van de infectieuze arthroconidia, vaak gevonden in de bodem. In de meeste gevallen is het een goedaardige, zelfbeperkende febriele ziekte, maar in een minderheid van de gevallen kan het een potentieel letale longinfectie worden en, uiterst zelden, verspreiden naar andere organen (door hematogene disseminatie) met manifestaties als meningitis, osteomyelitis en betrokkenheid van de huid en weke delen."},"pt":{"name":"Coccidioidomicose"},"pl":{"name":"Kokcydioidomikoza","synonyms":["Choroba Kalifornijska","Goraczka pustynna","Reumatyzm pustynny","Valley fever"]},"cs":{"name":"Kokcidiomykóza","synonyms":["Kalifornská nemoc","Kokcidiová infekce","Pouštní revmatismus","Pouštní horečka","Horečka údolí San Joaquin","Údolní horečka"]},"uk":{"name":"Кокцидіоїдомікоз","synonyms":["Каліфорнійська хвороба","Кокцидіозна інфекція","Лихоманка пустелі","Пустельний ревматизм","Лихоманка долини Сан-Хоакін","Лихоманка долини"],"definition":"Coccidioidomycosis is a fungal infection caused by <i>Coccidioides immitis</i> and <i>C. posadasii</i>, which is endemic to the Southwestern United States, Central America, South America and Mexico, and is acquired by inhalation of the infective arthroconidia, often found in soil. In most cases it is a benign, self-limiting febrile illness, but in a minority of cases it can become a potentially lethal infection of the lungs and, extremely rarely, spread to other organs (through hematogenous dissemination) with manifestations including meningitis, osteomyelitis, and skin and soft-tissue involvement."},"zh":{"name":"球孢子菌病","synonyms":["球孢子菌感染"],"definition":"球孢菌病是一种由粗球孢子菌 和posadasii球孢子菌 引起的真菌感染，该病流行于美国西南部、中美洲、南美洲和墨西哥，通过吸入土壤中常见的感染性节生孢子患病。在大多数情况下，它是一种良性的、自限性发热疾病，但在少数情况下，它可能成为肺部潜在的致命感染，极少数情况下会传播到其他器官（通过血行播散）表现为脑膜炎、骨髓炎、皮肤和软组织受累。"},"tr":{"name":"Koksidioidomikoz","synonyms":["Çöl ateşi","Vadi ateşi","Çöl romatizması","California hastalığı","Koksidfoid enfeksiyonu","San Joaquin vadisi ateşi"]}},"xrefs":[{"source":"ICD-10","code":"B38.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B38.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B38.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B38.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B38.4","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B38.7","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B38.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B38.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F25","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"132287989"},{"source":"ICD-11","code":"1F25.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1080392099"},{"source":"ICD-11","code":"1F25.00","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1367598280"},{"source":"ICD-11","code":"1F25.01","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"885533022"},{"source":"ICD-11","code":"1F25.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"71079562"},{"source":"ICD-11","code":"1F25.10","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"577599324"},{"source":"ICD-11","code":"1F25.11","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"623817783"},{"source":"ICD-11","code":"1F25.12","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1455433635"},{"source":"ICD-11","code":"1F25.1Y","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0005706","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D003047","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0009186","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9525","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10009825","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163591,"name":"Rare mycosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-23","source":"26739609[PMID]_30690606[PMID]_23068145[PMID]","terms":[{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003237","label":"Increased circulating IgG level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003496","label":"Increased circulating IgM level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000707","label":"Abnormality of the nervous system","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025615","label":"Abscess","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000987","label":"Atypical scarring of skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200149","label":"CSF lymphocytic pleiocytosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012229","label":"CSF pleocytosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012735","label":"Cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012219","label":"Erythema nodosum","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011921","label":"Exudative pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025084","label":"Folliculitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032252","label":"Granuloma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011972","label":"Hypoglycorrhachia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002922","label":"Increased CSF protein concentration","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001880","label":"Increased total eosinophil count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032217","label":"Indurated nodule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002716","label":"Lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100721","label":"Mediastinal lymphadenopathy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012282","label":"Morbilliform rash","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012490","label":"Panniculitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200034","label":"Papule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032177","label":"Parenchymal consolidation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011919","label":"Pleural empyema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002113","label":"Pulmonary infiltrates","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002098","label":"Respiratory distress","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200035","label":"Skin plaque","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000988","label":"Skin rash","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011450","label":"Unusual CNS infection","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030351","label":"Urticarial plaque","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012500","label":"Verrucous papule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005916","label":"Abnormal metacarpal morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000479","label":"Abnormal retinal morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012864","label":"Abnormal sperm morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001871","label":"Abnormality of blood and blood-forming tissues","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011314","label":"Abnormality of long bone morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000014","label":"Abnormality of the bladder","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000818","label":"Abnormality of the endocrine system","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0010460","label":"Abnormality of the female genitalia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000119","label":"Abnormality of the genitourinary system","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000077","label":"Abnormality of the kidney","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001392","label":"Abnormality of the liver","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0010461","label":"Abnormality of the male genitalia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001743","label":"Abnormality of the spleen","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000925","label":"Abnormality of the vertebral column","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000622","label":"Blurred vision","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001783","label":"Broad metatarsal","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000885","label":"Broad ribs","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002682","label":"Broad skull","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002637","label":"Cerebral ischemia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0032161","label":"Coccidioidal meningitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100543","label":"Cognitive impairment","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000365","label":"Hearing impairment","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000238","label":"Hydrocephalus","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0020101","label":"Invasive fungal infection","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031179","label":"Nuchal rigidity","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002797","label":"Osteolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001733","label":"Pancreatitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001701","label":"Pericarditis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002586","label":"Peritonitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000751","label":"Personality changes","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000083","label":"Renal insufficiency","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002633","label":"Vasculitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025637","label":"Vasospasm","frequency":"Very rare (<4-1%)","criteria":null}]}}