{"orpha":228119,"name":"Fusariosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Fusarium infection"],"definition":"Fusariosis describes a superficial, locally invasive, disseminated infection with the pathogenic fungus species, <i>Fusarium</i>, often found in soil and water, which is mainly transmitted to humans through traumatic inoculation and that manifests with keratitis, onychomycosis and less frequently peritonitis and cellulitis. In the immunocompromised, disseminated fusariosis is more common and it manifests with refractory fever, skin lesions (ecthyma-like, target, and multiple subcutaneous nodules), severe myalgias and sino-pulmonary infections.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-228119/","orphanet_url":"https://www.orpha.net/en/disease/detail/228119","names":{"fr":{"name":"Fusariose","definition":"La fusariose décrit une infection superficielle, disséminée et localement invasive par <i>Fusarium</i>, une espèce fongique pathogène principalement présente dans le sol et dans l'eau, le plus souvent transmise à l'homme par inoculation traumatique et se manifestant par une kératite, une onychomycose et, moins fréquemment, une péritonite et une cellulite. La fusariose disséminée est plus commune chez l'immunodéprimé et se manifeste par une fièvre persistante, des lésions cutanées (ecthyma-like, en cocarde, nodules sous-cutanés multiples), des myalgies sévères et des infections sino-pulmonaires."},"de":{"name":"Fusariose","synonyms":["Fusarium-Infektion"],"definition":"Fusariose beschreibt eine oberflächliche, lokal invasive, disseminierte Infektion durch den pathogenen Schlauchpilz der Gattung <i>Fusarium</i>, der sich oft im Erdboden und Gewässern befindet und hauptsächlich über Verletzung auf Menschen übertragen wird. Sie äußert sich als Keratitis, Onychomykose und seltener als Peritonitis und Cellulitis. Bei Immungeschwächten tritt eine disseminierte Fusariose häufiger auf und manifestiert sich in hartnäckigem Fieber, Hautläsionen (Ekthym-ähnlich, multiple subkutane Knötchen), schweren Myalgien sowie Infektion der Lungen und Nasennebenhöhlen."},"es":{"name":"Fusariosis","synonyms":["Infección por Fusarium"],"definition":"El término fusariosis describe una infección superficial, diseminada y localmente invasiva de las especies patógenas del hongo <i>Fusarium</i>, que a menudo se encuentra en el suelo y en el agua y que se transmite a los humanos principalmente mediante inoculación traumática. Se manifiesta en forma de queratitis, onicomicosis y, con menos frecuencia, peritonitis y celulitis. En las personas inmunodeprimidas, la fusariosis diseminada es más común, y se manifiesta en forma de fiebre refractaria, lesiones cutáneas (ectimatosas y múltiples nódulos subcutáneos), mialgias intensas e infecciones sinopulmonares."},"it":{"name":"Fusariosi","synonyms":["Infezione da Fusarium"],"definition":"La fusariosi è un'infezione superficiale disseminata, invasiva a livello locale, dovuta a una specie di funghi patogeni, <i>Fusarium</i>, spesso presenti nel terreno e nell'acqua. Si trasmette all'uomo essenzialmente mediante l'inoculazione traumatica e si presenta con cheratite, onicomicosi e, meno spesso, peritonite e cellulite. Nelle persone immunocompromesse, la fusariosi disseminata è più comune e si manifesta con febbre refrattaria, lesioni cutanee (noduli ectima-simili, bersaglio, e sottocutanei multipli), mialgia grave e infezioni sinopolmonari."},"nl":{"name":"Fusariose","synonyms":["Fusariuminfectie"],"definition":"Fusariose beschrijft een oppervlakkige, lokaal invasieve, verspreide infectie met het pathogene fungusgenus <i>Fusarium</i>, die vaak gevonden wordt in de bodem en het water en die voornamelijk overgedragen wordt op mensen via inoculatie door trauma. De ziekte manifesteert zich met keratitis, onychomycose en minder frequent peritonitis en cellulitis. Bij immuungecompromitteerden komt verspreide fusariose vaker voor en manifesteert het zich met refractaire koorts, huidlaesies (ecthyma-achtige, schietschijf-, en meervoudige subcutane nodules), ernstige myalgieën en sinopulmonale infecties."},"pt":{"name":"Fusariose"},"pl":{"name":"Fuzarioza","synonyms":["Zakażenie Fusarium"]},"cs":{"name":"Fuzarióza","synonyms":["Fuzariová infekce"]},"uk":{"name":"Фузаріоз","synonyms":["Фузаріозна інфекція"],"definition":"Fusariosis describes a superficial, locally invasive, disseminated infection with the pathogenic fungus species, <i>Fusarium</i>, often found in soil and water, which is mainly transmitted to humans through traumatic inoculation and that manifests with keratitis, onychomycosis and less frequently peritonitis and cellulitis. In the immunocompromised, disseminated fusariosis is more common and it manifests with refractory fever, skin lesions (ecthyma-like, target, and multiple subcutaneous nodules), severe myalgias and sino-pulmonary infections."},"zh":{"name":"镰刀菌病","synonyms":["镰刀菌感染"],"definition":"镰刀菌病是一种浅表性、局部侵袭性、播散性的病原真菌感染。 镰刀菌通常存在于土壤和水中，主要通过接触伤口传染给人类，表现为角膜炎、甲癣和不常见的腹膜炎、蜂窝织炎。在免疫功能低下的患者中，播散性镰刀菌病更为常见，表现为顽固性发热、皮肤病变（脓疱样、靶形和多发性皮下结节）、严重肌痛和窦肺感染。"},"tr":{"name":"Fusarioz","synonyms":["Fusarium enfeksiyonu"]}},"xrefs":[{"source":"ICD-10","code":"B48.7","qualifier":"NTBT","icd_relation":"index","validated":true},{"source":"ICD-11","code":"1F2Z","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1939815950"},{"source":"MONDO","code":"0016426","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D060585","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0276758","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10051919","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163591,"name":"Rare mycosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-23","source":"26398537[PMID]_30102950[PMID]_14748803[PMID]","terms":[{"hpo":"HP:0020153","label":"Positive blood 1,3 beta glucan test","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001875","label":"Decreased total neutrophil count","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0020101","label":"Invasive fungal infection","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012203","label":"Onychomycosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002090","label":"Pneumonia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011356","label":"Regional abnormality of skin","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000246","label":"Sinusitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100749","label":"Chest pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032252","label":"Granuloma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025179","label":"Ground-glass opacification on pulmonary HRCT","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004377","label":"Hematological neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002105","label":"Hemoptysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006516","label":"Hypersensitivity pneumonitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001888","label":"Lymphopenia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040186","label":"Maculopapular exanthema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003326","label":"Myalgia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200034","label":"Papule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032177","label":"Parenchymal consolidation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001818","label":"Paronychia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002202","label":"Pleural effusion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031245","label":"Productive cough","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002113","label":"Pulmonary infiltrates","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031457","label":"Pulmonary opacity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200042","label":"Skin ulcer","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001482","label":"Subcutaneous nodule","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008066","label":"Abnormal blistering of the skin","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000479","label":"Abnormal retinal morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000077","label":"Abnormality of the kidney","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001392","label":"Abnormality of the liver","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001743","label":"Abnormality of the spleen","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0032172","label":"Air crescent sign","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001369","label":"Arthritis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0030049","label":"Brain abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002110","label":"Bronchiectasis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100658","label":"Cellulitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100537","label":"Fasciitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000491","label":"Keratitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025044","label":"Lung abscess","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0100614","label":"Myositis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002754","label":"Osteomyelitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0410017","label":"Otitis externa","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012490","label":"Panniculitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002586","label":"Peritonitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0032156","label":"Skin detachment","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011450","label":"Unusual CNS infection","frequency":"Very rare (<4-1%)","criteria":null}]}}