{"orpha":228113,"name":"Anal fistula","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare intestinal condition characterized by an abnormal communication between the lower rectum and the perianal skin, which usually develops after an acute perianal abscess. A fistulous traject may be established on either side of the anus (never in the midline) and mucous or fecal discharge can appear. The skin around the external orifice can be irritated. Males are more often affected than females.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-228113/","orphanet_url":"https://www.orpha.net/en/disease/detail/228113","names":{"fr":{"name":"Fistule anale","definition":"Maladie intestinale rare caractérisée par une communication anormale entre le bas du rectum et la peau périanale, qui se forme généralement à la suite d'un abcès périanal aigu. Un trajet fistulaire progresse de chaque côté de l'anus (jamais dans la ligne médiane) et on peut observer parfois un écoulement muqueux ou fécal. La peau autour de l'orifice externe peut être irritée. Les hommes sont plus souvent touchés que les femmes."},"de":{"name":"Analfistel","definition":"Eine seltene Darmerkrankung, die durch eine abnorme Verbindung zwischen dem unteren Rektum und der perianalen Haut gekennzeichnet ist und sich gewöhnlich nach einem akuten perianalen Abszess entwickelt. Auf beiden Seiten des Afters (nie in der Mittellinie) kann sich eine Fistel bilden, und es kann Schleim oder Stuhl austreten. Die Haut um die äußere Öffnung kann gereizt sein. Männer sind häufiger betroffen als Frauen."},"es":{"name":"Fístula anal","definition":"Es una enfermedad intestinal poco frecuente caracterizada por una comunicación anómala entre la parte inferior del recto y la piel perianal, que suele desarrollarse después de un absceso perianal agudo. Puede establecerse un trayecto fistuloso a ambos lados del ano (nunca en la línea media) y presentar secreciones mucosas o fecales, con posible irritación de la piel que circunda el orificio externo. Los varones se ven afectados con mayor frecuencia que las mujeres."},"it":{"name":"Fistola anale","definition":"Si tratta di una malattia intestinale rara, caratterizzata da una comunicazione anomala tra la porzione inferiore del retto e la cute perianale, che di solito si sviluppa a seguito di un ascesso perianale acuto. La fistola può svilupparsi su entrambi i lati dell'ano (mai sulla linea mediana) e può associarsi ad una secrezione mucosa o fecale. La pelle attorno all'orifizio esterno può essere irritata. I maschi sono maggiormente colpiti."},"nl":{"name":"Anale fistel","definition":"Een zeldzame aandoening van darm, gekarakteriseerd door een abnormale communicatie tussen onderste deel van rectum en perianale huid, die meestal ontwikkelt na een acuut perianaal abces. Er kan een fistuleus traject gevormd worden aan weerszijden van anus (nooit op de middellijn) en er kan muceuze of fecale afscheiding verschijnen. Huid rond de uitwendige opening kan geïrriteerd zijn. Mannen worden vaker getroffen dan vrouwen."},"pt":{"name":"Fístula anal"},"pl":{"name":"Przetoka odbytu"},"cs":{"name":"Anální píštěl"},"uk":{"name":"Анальна нориця","definition":"A rare intestinal condition characterized by an abnormal communication between the lower rectum and the perianal skin, which usually develops after an acute perianal abscess. A fistulous traject may be established on either side of the anus (never in the midline) and mucous or fecal discharge can appear. The skin around the external orifice can be irritated. Males are more often affected than females."},"zh":{"name":"肛瘘","definition":"一种罕见的肠道疾病，其特征是直肠下部和肛周皮肤之间的不正常连通，通常在急性肛周脓肿后形成。肛门两侧（除外中线）可形成瘘管，并可出现粘液或排泄物。瘘管外孔周围的皮肤可能会受到刺激。男性比女性更容易受到感染。"},"tr":{"name":"Anal fistül"}},"xrefs":[{"source":"ICD-10","code":"K60.3","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"DB50.1","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"206903882"},{"source":"MONDO","code":"0000754","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0205929","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10002156","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97935,"name":"Rare gastroenterologic disease"},"parents":[{"orpha":165711,"name":"Rare abdominal surgical disease","classifications":[182]},{"orpha":117569,"name":"Rare intestinal disease","classifications":[152]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":18.3,"area":"Europe","status":"Validated","source":"DOI:10.12998/wjcc.v7.i14.1795[OTHER]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":18.0,"area":"United Kingdom","status":"Validated","source":"DOI:10.12998/wjcc.v7.i14.1795[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-08-18","source":"20004071[PMID]_28620877[PMID]","terms":[{"hpo":"HP:0005218","label":"Anoperineal fistula","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0500005","label":"Anal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100658","label":"Cellulitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001974","label":"Increased total leukocyte count","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025143","label":"Chills","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Very rare (<4-1%)","criteria":null}]}}