{"orpha":227972,"name":"Toxic oil syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Toxic oil syndrome is a rare intoxication, due to consumption of a rapeseed oil denatured with aniline 2%, characterized by generalized vascular lesions affecting all organs and vessels (including veins and arteries) and presenting with severe incapacitating myalgias, marked peripheral eosinophilia and pulmonary infiltrates.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-227972/","orphanet_url":"https://www.orpha.net/en/disease/detail/227972","names":{"fr":{"name":"Syndrome de l'huile toxique","synonyms":["Syndrome de l'huile frelatée"],"definition":"Intoxication rare, due à la consommation d'une huile de colza dénaturée à l'aniline à 2 %, caractérisée par des lésions vasculaires généralisées touchant tous les organes et vaisseaux (y compris les veines et les artères), se manifestant par des myalgies invalidantes sévères, une éosinophilie périphérique marquée et des infiltrats pulmonaires."},"de":{"name":"Toxisches Öl-Syndrom","synonyms":["Toxic-Oil-Syndrom"],"definition":"Das Toxic-oil-Syndrom (TOS) ist eine seltene Intoxikation, die auf den Verzehr eines mit 2% Anilin denaturierten Rapsöls zurückzuführen ist. Sie ist gekennzeichnet durch generalisierte vaskuläre Läsionen, die alle Organe und Gefäße (einschließlich Venen und Arterien) betreffen und sich durch schwere handlungseinschränkende Myalgien, ausgeprägte periphere Eosinophilie und pulmonale Infiltrate äußern."},"es":{"name":"Síndrome del aceite tóxico","definition":"El Síndrome del Aceite Tóxico (SAT) es una intoxicación poco frecuente por consumo de aceite de colza desnaturalizado con anilina al 2%. La enfermedad se caracteriza por la presencia de una afectación vascular generalizada, afectando tanto a venas como arterias de todos los tamaños y órganos y presentándose con mialgias severas e incapacitantes, marcada eosinofilia e infiltrados pulmonares."},"it":{"name":"Sindrome dell'olio tossico","definition":"La sindrome dell'olio tossico è un'intossicazione rara causata dall'assunzione di olio di colza denaturato con anilina al 2%. È caratterizzata da lesioni vascolari generalizzate che interessano tutti gli organi e tutti i vasi (vene e arterie comprese). La malattia esordisce con gravi mialgie invalidanti, eosinofilia periferica marcata e infiltrati polmonari."},"nl":{"name":"Toxische olie-syndroom","definition":"Toxische olie-syndroom (TOS) is een zeldzame vergiftiging, als gevolg van consumptie van koolzaadolie gedenatureerd met 2% aniline, die gekarakteriseerd wordt door gegeneraliseerde vasculaire laesies die alle organen en bloedvaten aantasten (inclusief aders en slagaders) en die zich presenteert met ernstige invaliderende spierpijn, aanzienlijke perifere eosinofilie en pulmonale infiltraten."},"pt":{"name":"Síndrome do óleo tóxico"},"pl":{"name":"Zespół toksycznego oleju"},"cs":{"name":"Syndrom toxického oleje"},"uk":{"name":"Синдром токсичного масла","definition":"Toxic oil syndrome is a rare intoxication, due to consumption of a rapeseed oil denatured with aniline 2%, characterized by generalized vascular lesions affecting all organs and vessels (including veins and arteries) and presenting with severe incapacitating myalgias, marked peripheral eosinophilia and pulmonary infiltrates."},"zh":{"name":"油毒综合征","definition":"毒油综合征是一种罕见的中毒，由食用了含2%苯胺的变性菜籽油所致，其特征是累及所有器官和血管（包括静脉和动脉）全身血管病变，并表现为严重的失能性肌痛、外周嗜酸性粒细胞明显增多和肺浸润。"},"tr":{"name":"Zehirli yağ sendromu"}},"xrefs":[{"source":"ICD-10","code":"X46","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"NE61","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0016421","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0409998","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10051222","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":108999,"name":"Rare disorder due to toxic effects"},"parents":[{"orpha":556508,"name":"Rare disorder due to poisoning","classifications":[204]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET_12192735[PMID]"},{"type":"Cases/families","qualification":"Case(s)","class":null,"value":20000.0,"area":"Worldwide","status":"Validated","source":"12192735[PMID]"}],"phenotypes":null}