{"orpha":221098,"name":"Glossopharyngeal neuralgia","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare cranial neuralgia characterized by paroxysmal, usually unilateral stabbing pain within the sensory distributions of the auricular and pharyngeal branches of the glossopharyngeal and sometimes the vagus nerve (i. e. the posterior part of the tongue, the tonsillar fossa, oropharynx, larynx, angle of the mandible, and/or ear). The attacks last seconds to minutes with intervals between the paroxysms ranging from a few minutes to a few hours, and appear in clusters lasting weeks to months, again with irregular intervals in between. Pain attacks are usually triggered by a specific stimulus but may also occur spontaneously. The condition can sometimes be associated with bradycardia, syncope, seizures, and even asystole, and is then termed vagoglossopharyngeal neuralgia.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-221098/","orphanet_url":"https://www.orpha.net/en/disease/detail/221098","names":{"fr":{"name":"Névralgie glossopharyngienne","synonyms":["Névralgie du glossopharyngien","Névralgie glossopharyngée"],"definition":"Névralgie crânienne rare caractérisée par une douleur lancinante paroxystique, généralement unilatérale, dans la zone de distribution des branches sensorielles auriculaires et pharyngées du nerf glossopharyngien et parfois du nerf vague (c'est-à-dire la partie postérieure de la langue, la fosse amygdalienne, l'oropharynx, le larynx, l'angle de la mandibule et/ou l'oreille). Les crises, d'une durée de quelques secondes à quelques minutes, sont ponctuées d'intervalles de douleur paroxystique persistant entre quelques minutes et quelques heures, et peuvent survenir par séries d'une durée de plusieurs semaines à plusieurs mois chacune, là encore à des intervalles irréguliers. Les crises sont généralement déclenchées par un stimulus spécifique, mais peuvent aussi survenir spontanément. La maladie peut parfois être associée à une bradycardie, une syncope, des convulsions, voire une asystolie, appelée alors névralgie vago-glossopharyngienne."},"de":{"name":"Glossopharyngeusneuralgie","definition":"Eine seltene kraniale Neuralgie, die durch paroxysmale, meist einseitige stechende Schmerzen in den sensorischen Verteilungen der aurikulären und pharyngealen Äste des N. glossopharyngeus und manchmal des N. vagus gekennzeichnet ist (d. h. hinterer Teil der Zunge, Fossa tonsillaris, Oropharynx, Larynx, Unterkieferwinkel und/oder Ohr). Die Anfälle dauern Sekunden bis Minuten, wobei die Intervalle zwischen den Paroxysmen von einigen Minuten bis zu einigen Stunden reichen, und treten in Gruppen auf, die Wochen bis Monate andauern, wiederum mit unregelmäßigen Intervallen dazwischen. Die Schmerzattacken werden in der Regel durch einen bestimmten Reiz ausgelöst, können aber auch spontan auftreten. Die Erkrankung kann manchmal mit Bradykardie, Synkope, Krampfanfällen und sogar Asystolie einhergehen und wird dann als vagoglossopharyngeale Neuralgie bezeichnet."},"es":{"name":"Neuralgia glosofaríngea","definition":"Es una neuralgia craneal poco frecuente caracterizada por un dolor punzante paroxístico, generalmente unilateral, en las distribuciones sensitivas de la rama auricular y faríngea del nervio glosofaríngeo y, en ocasiones, del nervio vago (es decir, la parte posterior de la lengua, la fosa amigdalina, la orofaringe, la laringe, el ángulo mandibular y/o el pabellón auricular). Los episodios duran de segundos a minutos con intervalos entre los paroxismos que varían desde unos minutos a unas horas, y se presentan agrupados en un espacio de semanas o meses, con intervalos irregulares entre ellos. Por lo general, los episodios de dolor están desencadenados por un estímulo específico, aunque también pueden producirse de manera espontánea. En ocasiones el trastorno puede estar asociado a bradicardia, síncope, crisis epilépticas e incluso asistolia, en cuyo caso se denomina neuralgia vagoglosofaríngea."},"it":{"name":"Nevralgia glossofaringea","synonyms":["Nevralgia glosso-vaso-faringea"],"definition":"Si tratta di una nevralgia cranica rara, caratterizzata da dolore pungente parossistico, di solito monolaterale, localizzato nelle distribuzioni sensoriali del ramo auricolare e faringeo del nervo glossofaringeo e, talvolta, del nervo vago (porzione posteriore della lingua, fossa tonsillare, orofaringe, laringe, angolo della mandibola e/o orecchio). Gli episodi durano qualche secondo o minuto, con intervalli tra gli episodi parossistici che vanno da alcuni minuti ad alcune ore; si raggruppano in cluster che durano settimane o mesi, con intervalli irregolari tra l'uno e l'altro episodio. Di solito gli episodi dolorosi sono scatenati da uno stimolo specifico, ma possono anche insorgere spontaneamente. La malattia può associarsi a bradicardia, sincope, crisi epilettiche e anche ad asistole; in questo caso viene definita nevralgia vasoglossofaringea."},"nl":{"name":"Glossofaryngeale neuralgie","synonyms":["Neuralgie van nervus glossopharyngeus"],"definition":"Een zeldzame craniale neuralgie, gekarakteriseerd door paroxysmale, meestal unilaterale stekende pijn in gebieden met innervatie door de auriculaire en faryngeale takken van de nervus glossopharyngeus en soms de nervus vagus (i.e. achterste deel van de tong, fossa tonsillaris, orofarynx, larynx, kaakhoek, en/of oor). De aanvallen duren seconden tot minuten met intervallen tussen de aanvallen gaande van enkele minuten tot enkele uren, en verschijnen in clusters die weken tot maanden duren, opnieuw met onregelmatige intervallen ertussen. Pijnaanvallen worden doorgaans uitgelokt door een specifieke stimulus, maar kunnen ook spontaan voorkomen. De aandoening kan soms geassocieerd zijn met bradycardie, syncope, insulten, en zelfs asystolie, en wordt dan vagoglossofaryngeale neuralgie genoemd."},"pt":{"name":"Neuralgia glossofaríngea"},"pl":{"name":"Neuralgia nerwu językowo-gardłowego","synonyms":["Neuralgia językowo-błędno-gardłowa"]},"cs":{"name":"Glossofaryngeální neuralgie","synonyms":["Glossovasofaryngeální neuralgie"]},"uk":{"name":"Невралгія глоткового нерва","definition":"A rare cranial neuralgia characterized by paroxysmal, usually unilateral stabbing pain within the sensory distributions of the auricular and pharyngeal branches of the glossopharyngeal and sometimes the vagus nerve (i. e. the posterior part of the tongue, the tonsillar fossa, oropharynx, larynx, angle of the mandible, and/or ear). The attacks last seconds to minutes with intervals between the paroxysms ranging from a few minutes to a few hours, and appear in clusters lasting weeks to months, again with irregular intervals in between. Pain attacks are usually triggered by a specific stimulus but may also occur spontaneously. The condition can sometimes be associated with bradycardia, syncope, seizures, and even asystole, and is then termed vagoglossopharyngeal neuralgia."},"zh":{"name":"舌咽神经痛","definition":"一种罕见的颅神经痛，其特征是在舌咽的耳支和咽支的支配的感觉范围内，有时是迷走神经（即舌后部、扁桃体窝、口咽、喉、下颌角和/或耳）支配的的感觉范围内的阵发性，通常单侧的刺痛。这些疼痛每次发作持续几秒到几分钟，发作间隔从几分钟到几小时不等，并且成簇出现，病程持续数周到数月，其间隔时间也不规则。疼痛发作通常是由特定的刺激引起的，但也可能是自发的。该病有时与心动过缓、晕厥、癫痫发作甚至心脏停搏有关，因此被称为迷走神经痛。"},"tr":{"name":"Glossofarengeal nevralji"}},"xrefs":[{"source":"ICD-10","code":"G52.1","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"8B87","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"539748746"},{"source":"MONDO","code":"0016372","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D020435","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0154731","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6519","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10018391","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":221109,"name":"Cranial neuralgia","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adolescent","Adult","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.7,"area":"United States","status":"Validated","source":"1798430[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-03-23","source":"30361762[PMID]_31082085[PMID]_28827979[PMID]","terms":[{"hpo":"HP:3000047","label":"Abnormal glossopharyngeal nerve morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000739","label":"Anxiety","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001293","label":"Cranial nerve compression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030766","label":"Ear pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032148","label":"Episodic pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030164","label":"Jaw claudication","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0200025","label":"Mandibular pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030811","label":"Tongue pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000174","label":"Abnormal palate morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003319","label":"Abnormality of the cervical spine","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002960","label":"Autoimmunity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001662","label":"Bradycardia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007099","label":"Chiari type I malformation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002617","label":"Dilatation","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012534","label":"Dysesthesia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011968","label":"Feeding difficulties","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002315","label":"Headache","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001609","label":"Hoarse voice","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004395","label":"Malnutrition","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002664","label":"Neoplasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032043","label":"Odynophagia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0200136","label":"Oral-pharyngeal dysphagia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100008","label":"Schwannoma","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001279","label":"Syncope","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001605","label":"Vocal cord paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001824","label":"Weight loss","frequency":"Occasional (29-5%)","criteria":null}]}}