{"orpha":217260,"name":"Progressive multifocal leukoencephalopathy","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["PML","Progressive multifocal leukoencephalitis"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-217260/","orphanet_url":"https://www.orpha.net/en/disease/detail/217260","names":{"fr":{"name":"Leucoencéphalopathie multifocale progressive","synonyms":["LMP","Leucoencéphalite multifocale progressive"]},"de":{"name":"Leukoenzephalopathie, multifokale progressive","synonyms":["Leukoenzephalitis, multifokale progressive","PML"]},"es":{"name":"Leucoencefalopatía multifocal progresiva","synonyms":["LMP","Leucoencefalitis multifocal progresiva"]},"it":{"name":"Leucoencefalopatia multifocale progressiva","synonyms":["Leucoencefalite multifocale progressiva"]},"nl":{"name":"Progressieve multifocale leuko-encefalopathie","synonyms":["PML","Progressieve multifocale leuko-encefalitis"]},"pt":{"name":"Leucoencefalite multifocal 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ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.068,"area":"Sweden","status":"Validated","source":"29321229[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.11,"area":"France","status":"Validated","source":"35779271[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-02-25","source":"29231623[PMID]_31580233[PMID]_30366552[PMID]_26421780[PMID]","terms":[{"hpo":"HP:0100707","label":"Abnormal astrocyte morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0031392","label":"Abnormal proportion of CD4 T cells","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002921","label":"Abnormality of the cerebrospinal fluid","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000707","label":"Abnormality of the nervous system","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0100706","label":"Abnormality of the oligodendroglia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0007305","label":"CNS demyelination","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0004302","label":"Functional motor deficit","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002167","label":"Abnormality of speech or vocalization","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100543","label":"Cognitive impairment","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0005415","label":"Decreased proportion of CD8-positive T cells","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001260","label":"Dysarthria","frequency":"Frequent 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