{"orpha":217067,"name":"Pouchitis","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare intestinal disease characterized by non-specific inflammation of the ileal reservoir following ileal pouch anal anastomosis surgery. It generally occurs after the restoration of the fecal stream through the pouch and may be classified as acute or chronic, depending on the symptom duration (less or more than 4 weeks). Clinical presentation is variable and unspecific and commonly includes increased stool frequency and fluidity, rectal bleeding, abdominal cramps, bowel urgency, tenesmus, and nocturnal bowel incontinence.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-217067/","orphanet_url":"https://www.orpha.net/en/disease/detail/217067","names":{"fr":{"name":"Pochite","synonyms":["Pouchite"],"definition":"Maladie intestinale rare caractérisée par une inflammation non spécifique du réservoir iléal après une anastomose iléo-anale avec poche. Elle survient généralement après le rétablissement du flux fécal à travers la poche et peut être classée en tant qu'aiguë ou chronique, en fonction de la durée des symptômes (plus ou moins de 4 semaines). La présentation clinique est variable et non spécifique, à type d'augmentation de la fréquence et de la fluidité des selles, de saignements rectaux, de crampes abdominales, d'urgence intestinale, de ténesme et d'incontinence intestinale nocturne."},"de":{"name":"Pouchitis","definition":"Eine seltene Darmerkrankung, die durch eine unspezifische Entzündung des ilealen Reservoirs nach einer Operation zur Analanastomose des ilealen Pouches gekennzeichnet ist. Sie tritt in der Regel nach der Wiederherstellung des Stuhlgangs durch den Beutel auf und kann je nach Dauer der Symptome (weniger oder mehr als 4 Wochen) als akut oder chronisch eingestuft werden. Die klinische Präsentation ist variabel und unspezifisch und umfasst häufig eine erhöhte Stuhlfrequenz und -flüssigkeit, rektale Blutungen, Bauchkrämpfe, Stuhldrang, Tenesmen und nächtliche Stuhlinkontinenz."},"es":{"name":"Pouchitis","synonyms":["Reservoritis"],"definition":"Es una enfermedad intestinal poco común caracterizada por una inflamación inespecífica del reservorio ileal después de una anastomosis con bolsa ileoanal. Habitualmente, ocurre después de la restauración del flujo fecal a través de la bolsa y puede clasificarse como aguda o crónica, dependiendo de la duración de los síntomas (inferior o superior a 4 semanas). La presentación clínica es variable e inespecífica y comúnmente incluye aumento de la frecuencia y fluidez de las deposiciones, sangrado rectal, calambres abdominales, urgencia intestinal, tenesmo e incontinencia intestinal nocturna."},"it":{"name":"Pouchite"},"nl":{"name":"Pouchitis","definition":"Een zeldzame aandoening van darm, gekenmerkt door aspecifieke inflammatie van het ileumreservoir na operatief aanleggen van een ileum-pouch anale anastomose. Het treedt doorgaans op na herstel van de fecale stroom doorheen de pouch en kan geclassificeerd worden als acuut of chronisch, afhankelijk van de duur van de symptomen (minder of meer dan vier weken). Het klinische beeld is variabel en aspecifiek, en omvat doorgaans onder meer frequentie en vloeibaarheid van de ontlasting, rectaal bloedverlies, buikkrampen, fecale urgentie, tenesmus, en nachtelijke fecale incontinentie."},"pt":{"name":"Bolsite","definition":"Doença intestinal rara caracterizada por inflamação inespecífica do reservatório ileal após cirurgia de anastomose anal da bolsa ileal. Geralmente ocorre após a restauração do fluxo fecal através da bolsa e pode ser classificada como aguda ou crónica, dependendo da duração dos sintomas (menos ou mais de 4 semanas). A apresentação clínica é variável e inespecífica e comummente inclui aumento da frequência e fluidez das fezes, hemorragia retal, cólicas abdominais, urgência intestinal, tenesmo e incontinência intestinal noturna."},"pl":{"name":"Zapalenie zbiornika jelitowego","definition":"Rzadka choroba jelit charakteryzująca się nieswoistym zapaleniem zbiornika jelita krętego po operacji zespolenia odbytu ze zbiornikiem wytworzonym z jelita krętego. Zwykle występuje po przywróceniu przepływu kału przez zbiornik. Może mieć charakter ostry lub przewlekły, w zależności od czasu trwania objawów (mniej lub więcej niż 4 tygodnie). Obraz kliniczny jest zmienny i niespecyficzny i często obejmuje zwiększoną częstotliwość oddawania i płynność stolca, krwawienie z odbytu, skurcze w jamie brzusznej, (bolesne) parcie na stolec i nocne nietrzymanie stolca."},"cs":{"name":"Pouchitida"},"uk":{"name":"Пухирчатка","definition":"A rare intestinal disease characterized by non-specific inflammation of the ileal reservoir following ileal pouch anal anastomosis surgery. It generally occurs after the restoration of the fecal stream through the pouch and may be classified as acute or chronic, depending on the symptom duration (less or more than 4 weeks). Clinical presentation is variable and unspecific and commonly includes increased stool frequency and fluidity, rectal bleeding, abdominal cramps, bowel urgency, tenesmus, and nocturnal bowel incontinence."},"zh":{"name":"隐窝炎"},"tr":{"name":"Pouchit"}},"xrefs":[{"source":"ICD-10","code":"K91.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"DE2Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0005312","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D019449","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0376620","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10036463","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97935,"name":"Rare gastroenterologic disease"},"parents":[{"orpha":117569,"name":"Rare intestinal disease","classifications":[152]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":22.0,"area":"Europe","status":"Validated","source":"European Medicines Agency[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-08-18","source":"35958439[PMID]_29713128[PMID]_34335051[PMID]","terms":[{"hpo":"HP:0032155","label":"Abdominal cramps","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0500005","label":"Anal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002607","label":"Bowel incontinence","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012701","label":"Bowel urgency","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0032168","label":"Clostridium difficile colitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002573","label":"Hematochezia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012702","label":"Tenesmus","frequency":"Frequent (79-30%)","criteria":null}]}}