{"orpha":213837,"name":"Malignant germ cell tumor of the cervix uteri","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Cervical germ cell cancer","Cervical malignant germ cell tumor","Germ cell cancer of the cervix uteri"],"definition":"Malignant germ cell tumor of the cervix uteri is an extremely rare uterine neoplasm characterized by a usually polypoid, friable tumor deriving from primordial germ cells located in the uterine cervix. Presentation is non-specific and often includes abnormal vaginal bleeding and/or discharge, a cervical mass protruding from the vagina, abdominal and/or pelvic pain or, less commonly, difficulty passing stool and perianal pain. Various histological subtypes (incl. dysgerminoma, yolk sac tumor, choriocarcinoma and malignant teratoma) are reported.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-213837/","orphanet_url":"https://www.orpha.net/en/disease/detail/213837","names":{"fr":{"name":"Tumeur germinale maligne du col de l'utérus","synonyms":["Cancer germinal cervical","Cancer germinal du col de l'utérus","Tumeur cervicale germinale maligne"],"definition":"Cancer rare de l'utérus caractérisé par une masse typiquement polypoïde dérivant de cellules germinales primordiales localisées dans l'endomètre. La présentation n'est pas spécifique et comprend souvent des saignements et/ou des pertes vaginales anormales, une masse faisant saillie dans le vagin, des douleurs abdominales et/ou pelviennes ou, plus rarement, des difficultés à aller à la selle et des douleurs périanales. Les sous-types histologiques les plus courants sont le tératome malin et la tumeur du sac vitellin."},"de":{"name":"Maligner Keimzelltumor der Cervix uteri","synonyms":["Keimzellkrebs der Cervix uteri","Keimzellkrebs, zervikaler","Keimzelltumor, maligner zervikaler"]},"es":{"name":"Tumor maligno de células germinales de cuello de útero","synonyms":["Cáncer cervical de células germinales","Cáncer de células germinales de cuello de útero","Tumor cervical maligno de células germinales"],"definition":"El tumor maligno de células germinales de cuello de útero es una neoplasia uterina extremadamente poco frecuente, caracterizada por un tumor friable, generalmente polipoide, derivado de células germinales primordiales ubicadas en el cuello uterino. La presentación es inespecífica, e incluye a menudo sangrado y/o flujo vaginal anómalo, una masa cervical que protruye la vagina, dolor abdominal y/o pélvico o, con menor frecuencia, dificultad en las deposiciones y dolor perianal. Se han descrito varios subtipos histológicos (que incluyen disgerminoma, tumor del saco vitelino, coriocarcinoma y teratoma maligno)."},"it":{"name":"Tumore maligno a cellule germinali della cervice uterina","synonyms":["Cancro a cellule germinali della cervice uterina","Cancro cervicale a cellule germinali","Tumore cervicale maligno a cellule germinali"],"definition":"Il tumore maligno a cellule germinali della cervice uterina è una neoplasia molto rara dell'utero, caratterizzata da un tumore friabile, in genere polipoide, derivato dalle cellule germinali primordiali della cervice uterina. I sintomi d'esordio sono aspecifici e spesso comprendono le emorragie e/o le perdite vaginali anomale, una massa cervicale che protrude dalla vagina, il dolore addominale e/o pelvico, oppure, più raramente, la difficoltà alla defecazione e il dolore perianale. Sono stati descritti diversi sottotipi istologici (disgerminoma, tumore del sacco vitellino, coriocarcinoma e teratoma maligno)."},"nl":{"name":"Maligne kiemceltumor van cervix uteri","synonyms":["Cervicale kiemcelkanker","Kiemcelkanker van cervix uteri","Kwaadaardige kiemceltumor van baarmoederhals","Maligne cervicale kiemceltumor"],"definition":"Maligne kiemceltumor van de baarmoederhals is een uiterst zeldzaam uterien neoplasma dat gekarakteriseerd wordt door een meestal polypoïde, broze tumor afgeleid van primordiale kiemcellen gesitueerd in de baarmoederhals. Het beeld is niet-specifiek en omvat vaak abnormale vaginale bloeding en/of afscheiding, een cervicale massa die uit de vagina steekt, abdominale en/of pelviene pijn of, minder gangbaar, moeizame stoelgang en perianale pijn. Er worden verscheidene histologische subtypes gerapporteerd (inclusief dysgerminoom, dooierzaktumor, choriocarcinoom en maligne teratoom)."},"pt":{"name":"Tumor maligno das células germinativas do colo do útero"},"pl":{"name":"Złośliwy guz zarodkowy szyjki macicy","synonyms":["Guz zarodkowy szyjki","Rak zarodkowy szyjki","Rak zarodkowy szyjki macicy"]},"cs":{"name":"Zhoubný nádor hrdla děložního ze zárodečných buněk","synonyms":["Cervikální rakovina ze zárodečných buněk","Cervikální zhoubný nádor ze zárodečných buněk","Rakovina hrdla děložního ze zárodečných buněk"]},"uk":{"name":"Злоякісна герміногенна пухлина шийки матки","synonyms":["Герміногенний рак шийки матки","Злоякісна герміногенна пухлина шийки матки","Плоскоклітинний рак шийки матки"],"definition":"Malignant germ cell tumor of the cervix uteri is an extremely rare uterine neoplasm characterized by a usually polypoid, friable tumor deriving from primordial germ cells located in the uterine cervix. Presentation is non-specific and often includes abnormal vaginal bleeding and/or discharge, a cervical mass protruding from the vagina, abdominal and/or pelvic pain or, less commonly, difficulty passing stool and perianal pain. Various histological subtypes (incl. dysgerminoma, yolk sac tumor, choriocarcinoma and malignant teratoma) are reported."},"zh":{"name":"子宫颈恶性生殖细胞肿瘤","synonyms":["子宫颈生殖细胞癌"],"definition":"子宫颈恶性生殖细胞瘤是一种极为罕见的子宫肿瘤，其特征是由位于子宫颈的原始生殖细胞产生的息肉样易碎肿瘤。临床表现为非特异性，通常包括异常阴道出血和/或分泌物、从阴道突出的宫颈肿块、腹部和/或盆腔疼痛，或不太常见的排便困难与肛周疼痛。已报道其各种组织学亚型（包括无性细胞瘤、卵黄囊瘤、绒毛膜癌和恶性畸胎瘤）。"},"tr":{"name":"Serviks uterinin habis germ hücreli tümörü","synonyms":["Servikal germ hücre kanseri","Servikal habis germ hücreli tümör","Rahim ağzı uteri'nin germ hücre kanseri"]}},"xrefs":[{"source":"ICD-10","code":"C53.0","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C53.1","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C53.8","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2C77.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1880907441"},{"source":"MONDO","code":"0016289","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4750752","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":213761,"name":"Rare cancer of cervix uteri","classifications":[202,205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}