{"orpha":213751,"name":"Malignant germ cell tumor of the corpus uteri","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Germ cell cancer of the corpus uteri"],"definition":"Malignant germ cell tumor of the corpus uteri is an extremely rare uterine neoplasm characterized by a typically polypoid mass deriving from primordial germ cells localized in the endometrium. Presentation is non-specific and often includes abnormal vaginal bleeding and/or discharge, a mass protruding from the vagina, abdominal and/or pelvic pain or, less commonly, difficulty passing stool and perianal pain. The malignant teratoma and yolk sac tumor histological subtypes are the most common.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-213751/","orphanet_url":"https://www.orpha.net/en/disease/detail/213751","names":{"fr":{"name":"Tumeur germinale maligne du corps de l'utérus","synonyms":["Cancer germinal du corps de l'utérus"],"definition":"Cancer rare de l'utérus caractérisé par une masse typiquement polypoïde dérivant de cellules germinales primordiales localisées dans l'endomètre. La présentation n'est pas spécifique et comprend souvent des saignements et/ou des pertes vaginales anormales, une masse faisant saillie dans le vagin, des douleurs abdominales et/ou pelviennes ou, plus rarement, des difficultés à aller à la selle et des douleurs périanales. Les sous-types histologiques les plus courants sont le tératome malin et la tumeur du sac vitellin."},"de":{"name":"Maligner Keimzelltumor des Corpus uteri","synonyms":["Keimzellkrebs des Corpus uteri"]},"es":{"name":"Tumor maligno de células germinales de cuerpo de útero","synonyms":["Cáncer de células germinales de cuerpo de útero"],"definition":"Es una neoplasia uterina muy poco frecuente caracterizada por una masa típicamente polipoide derivada de células germinales primordiales localizadas en el endometrio. La presentación es inespecífica y con frecuencia incluye sangrado y/o secreción vaginal anómala, una masa que protruye a través de la vagina, dolor abdominal y/o pélvico o, con menor frecuencia, dificultad en el paso de heces, así como dolor perianal. Los subtipos histológicos más comunes son los tumores del saco vitelino y los teratomas malignos."},"it":{"name":"Tumore maligno a cellule germinali del corpo dell'utero","synonyms":["Cancro a cellule germinali del corpo uterino"],"definition":"Il tumore maligno a cellule germinali del corpo dell'utero è una neoplasia molto rara, di solito caratterizzata da una massa polipoide che origina dalle cellule germinali primordiali dell'endometrio. I sintomi d'esordio sono aspecifici e spesso comprendono le emorragie e/o le perdite vaginali anomale, la presenza di una massa che protrude dalla vagina, il dolore addominale e/o pelvico, oppure, più raramente, la difficoltà alla defecazione e il dolore perianale. I sottotipi istologici più comuni sono il teratoma maligno e il tumore del sacco vitellino."},"nl":{"name":"Maligne kiemceltumor van corpus uteri","synonyms":["Kiemcelkanker van corpus uteri","Kwaadaardige kiemceltumor van baarmoederlichaam"],"definition":"Maligne kiemceltumor van het baarmoederlichaam is een uiterst zeldzaam uterien neoplasma dat gekarakteriseerd wordt door een doorgaans polypoïde massa afgeleid van primordiale kiemcellen gesitueerd in het endometrium. Het beeld is niet-specifiek en omvat vaak abnormale vaginale bloeding en/of afscheiding, een massa die uit de vagina steekt, abdominale en/of pelviene pijn of, minder gangbaar, moeizame stoelgang en perianale pijn. Maligne teratoom en dooierzaktumor zijn de histologische subtypes die het vaakst voorkomen."},"pt":{"name":"Tumor maligno de células germinativas do corpo uterino"},"pl":{"name":"Złośliwy rak zarodkowy trzonu macicy","synonyms":["Rak zarodkowy trzonu macicy"],"definition":"*Złośliwy rak zarodkowy trzonu macicy jest niezwykle rzadkim nowotworem macicy, który typowo charakteryzuje się obecnością polipowatej masą, wywodzącej się z pierwotnych komórek rozrodczych zlokalizowanych w endometrium. Objawy są niespecyficzne i często obejmują nieprawidłowe krwawienie z pochwy i/lub upławy, guz wystający z pochwy, ból brzucha i/lub miednicy lub rzadziej, trudności w oddawaniu stolca i ból okolicy odbytu. Najczęstszymi podtypami histologicznymi są potworniaki złośliwe i guz pęcherzyka żółtkowego."},"cs":{"name":"Zhoubný nádor těla děložního ze zárodečných buněk","synonyms":["Germinom hrdla děložního"]},"uk":{"name":"Злоякісна герміногенна пухлина тіла матки","synonyms":["Герміногенний рак тіла матки"],"definition":"Malignant germ cell tumor of the corpus uteri is an extremely rare uterine neoplasm characterized by a typically polypoid mass deriving from primordial germ cells localized in the endometrium. Presentation is non-specific and often includes abnormal vaginal bleeding and/or discharge, a mass protruding from the vagina, abdominal and/or pelvic pain or, less commonly, difficulty passing stool and perianal pain. The malignant teratoma and yolk sac tumor histological subtypes are the most common."},"zh":{"name":"子宫体恶性生殖细胞肿瘤","synonyms":["子宫体生殖细胞癌"],"definition":"子宫体恶性生殖细胞瘤是一种极为罕见的子宫肿瘤，其特征是由位于子宫内膜的原始生殖细胞产生的典型息肉样肿块。本病表现为非特异性，通常包括异常阴道出血和/或分泌物、突出阴道的肿块、腹部和/或盆腔疼痛，或不常见的排便困难与肛周疼痛。组织学上以畸胎瘤和卵黄瘤最常见。"},"tr":{"name":"Korpus uteri'nin habis germ hücre tümörü","synonyms":["Korpus uteri'nin germ hücre kanseri"]}},"xrefs":[{"source":"ICD-10","code":"C54.0","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C54.1","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C54.2","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C54.3","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C54.8","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2C76.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1345474058"},{"source":"MONDO","code":"0016273","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4750753","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":213569,"name":"Rare cancer of corpus uteri","classifications":[202,205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult","Elderly"],"prevalence":[],"phenotypes":null}