{"orpha":213746,"name":"Transitional cell carcinoma of the corpus uteri","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Endometrial transitional cell carcinoma"],"definition":"A rare uterine cancer characterized by a usually intracavitary, friable, relatively well-circumscribed tumor located in the corpus uteri, with possible infiltration of the myometrium, composed, microscopically, of cells resembling urothelial transition cells, with a papillary or polypoid growth pattern, typically admixed with another type of carcinoma (frequently endometrial adenocarcinoma), generally manifesting with postmenopausal vaginal bleeding.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-213746/","orphanet_url":"https://www.orpha.net/en/disease/detail/213746","names":{"fr":{"name":"Carcinome à cellules transitionnelles du corps de l'utérus","synonyms":["Carcinome à cellules transitionnelles de l'endomètre"],"definition":"Cancer rare de l'utérus caractérisé par une tumeur généralement intracavitaire, friable, relativement bien circonscrite, située dans le corps utérin, avec une infiltration possible du myomètre, dont l'observation au microscope révèle la présence de cellules ressemblant à des cellules transitionnelles urothéliales, d'aspect papillaire ou polypoïde, généralement associé à un autre type de carcinome (souvent un adénocarcinome de l'endomètre), se manifestant généralement par des métrorragies post-ménopausiques."},"de":{"name":"Transitionalzellkarzinom des Corpus uteri","synonyms":["Transitionalzellkarzinom, endometriales"],"definition":"Ein seltener Gebärmutterkrebs, der durch einen meist intrakavitären, brüchigen, relativ gut abgegrenzten Tumor im Corpus uteri mit möglicher Infiltration des Myometriums gekennzeichnet ist. Mikroskopisch besteht dieser aus urothelzellähnlichen Zellen (Übergangszellen) mit papillärem oder polypoidem Wachstumsmuster, typischerweise vermischt mit einer anderen Art von Karzinom (oft endometriales Adenokarzinom). Charakteristisch für diese Erkrankung sind postmenopausale vaginalen Blutungen."},"es":{"name":"Carcinoma de células transicionales de cuerpo de útero","synonyms":["Carcinoma de células transicionales del endometrio"],"definition":"Es un cáncer uterino poco frecuente caracterizado por un tumor, por lo general, intracavitario, friable, relativamente bien delimitado, localizado en el cuerpo uterino, con posible infiltración miometrial. Microscópicamente está compuesto por células similares a las células uroteliales (células de transición), con un patrón de crecimiento papilar o polipoide, típicamente mezclado con otro tipo de carcinoma (con frecuencia adenocarcinoma endometrial). Por lo general, se manifiesta con sangrado vaginal postmenopáusico."},"it":{"name":"Carcinoma a cellule transizionali del corpo dell'utero","synonyms":["Carcinoma a cellule transizionali dell'endometrio"],"definition":"È una neoplasia rara dell'utero, caratterizzata da un tumore di solito intracavitario, friabile, relativamente delimitato, localizzato nel corpo dell'utero, con possibile infiltrazione del miometrio. Dal punto di vista microscopico, è composto da cellule che assomigliano a quelle transizionali uroteliali, con crescita papillare o polipoide. In genere si associa ad un altro carcinoma (spesso l'adenocarcinoma dell'endometrio), ed esordisce con emorragie vaginali post-menopausali."},"nl":{"name":"Overgangscelcarcinoom van corpus uteri","synonyms":["Endometriaal overgangscelcarcinoom","Overgangscelcarcinoom van baarmoederlichaam"],"definition":"Een zeldzame baarmoederkanker gekarakteriseerd door een meestal intracavitaire, broze, relatief goed begrensde tumor in het baarmoederlichaam, met mogelijke infiltratie van het myometrium, die microscopisch bestaat uit cellen lijkend op urotheliale overgangscellen, met een papillair of polypoïd groeipatroon en typisch gemengd met een ander type carcinoom (vaak endometriaal adenocarcinoom), en die zich doorgaans manifesteert met postmenopauzale vaginale bloeding."},"pt":{"name":"Carcinoma de células de transição do corpo uterino"},"pl":{"name":"Rak przejściowokomórkowy trzonu macicy","synonyms":["Rak przejściowokomórkowy endometrium"]},"cs":{"name":"Karcinom těla děložního z přechodných buněk","synonyms":["Endometriální karcinom z přechodných buněk"]},"uk":{"name":"Перехідно-клітинна карцинома тіла матки","synonyms":["Перехідно-клітинна карцинома ендометрія"],"definition":"A rare uterine cancer characterized by a usually intracavitary, friable, relatively well-circumscribed tumor located in the corpus uteri, with possible infiltration of the myometrium, composed, microscopically, of cells resembling urothelial transition cells, with a papillary or polypoid growth pattern, typically admixed with another type of carcinoma (frequently endometrial adenocarcinoma), generally manifesting with postmenopausal vaginal bleeding."},"zh":{"name":"子宫体移行细胞癌","synonyms":["子宫内膜移行细胞癌"],"definition":"一种罕见的子宫癌，其特征是位于子宫体腔内的、易碎的、边界相对清楚的肿瘤，可能浸润子宫肌层，镜下可见由类似于尿路上皮细胞的细胞组成，具有乳头状或息肉状生长模式，通常与另一种类型的癌（常为子宫内膜腺癌）混合，一般表现为绝经后阴道出血。"},"tr":{"name":"Korpus uteri'nin geçiş hücreli karsinomu","synonyms":["Endometrial geçiş hücreli karsinom"]}},"xrefs":[{"source":"ICD-10","code":"C54.9","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2C76.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1146095758"},{"source":"MONDO","code":"0016272","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5191668","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":213569,"name":"Rare cancer of corpus uteri","classifications":[202,205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"}],"phenotypes":null}