{"orpha":213721,"name":"Undifferentiated carcinoma of the corpus uteri","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Endometrial undifferentiated carcinoma"],"definition":"Undifferentiated carcinoma of the corpus uteri is a rare cancer of corpus uteri presenting as a large, polypoid, intraluminal mass with necrosis, composed of small to intermediate-size, relatively uniform, dyshesive cells displaying no differentiation. It usually presents with dysfunctional bleeding or vaginal discharge and, less often, abdominal pain. Association with Lynch syndrome was reported.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-213721/","orphanet_url":"https://www.orpha.net/en/disease/detail/213721","names":{"fr":{"name":"Carcinome indifférencié du corps de l'utérus","synonyms":["Carcinome indifférencié de l'endomètre"],"definition":"Un cancer rare du corps de l'utérus se manifestant par une large masse polypoïde intraluminale nécrosante, composée de cellules relativement uniformes, de petite taille à une taille intermédiaire, non cohésives et non différenciées. Il se manifeste habituellement par un saignement dysfonctionnel ou une perte vaginale, et plus rarement, par une douleur abdominale. Une association avec le syndrome de Lynch a été rapportée."},"de":{"name":"Undifferenziertes Karzinom des Corpus uteri","synonyms":["Karzinom, endometriales undifferenziertes"],"definition":"Das undifferenzierte Karzinom des Corpus uteri ist ein seltener Krebs des Corpus uteri, der sich als große, polypoide, intraluminale Masse mit Nekrose präsentiert, die aus kleinen bis mittelgroßen, relativ einheitlichen, dyshäsiven Zellen besteht, die keine Differenzierung aufweisen. In der Regel treten dysfunktionelle Blutungen oder vaginaler Ausfluss auf, seltener auch abdominelle Schmerzen. Es wurde über eine Assoziation mit dem Lynch-Syndrom berichtet."},"es":{"name":"Carcinoma indiferenciado de cuerpo uterino","synonyms":["Carcinoma indiferenciado del endometrio"],"definition":"El carcinoma indiferenciado de cuerpo uterino, es un cáncer poco frecuente de cuerpo uterino que se presenta como una gran masa polipoide intraluminal necrosada, compuesta de células discohesivas de tamaño pequeño a intermedio, relativamente uniformes que no muestran diferenciación. Por lo general, se presenta con sangrado disfuncional o flujo vaginal y, con menor frecuencia, dolor abdominal. Se ha descrito asociación con el síndrome de Lynch."},"it":{"name":"Carcinoma non differenziato del corpo dell'utero","synonyms":["Carcinoma non differenziato dell'endometrio"],"definition":"Il carcinoma non differenziato del corpo dell'utero è una neoplasia rara, che si manifesta come massa polipoide intraluminale necrotizzante di ampie dimensioni, composta da cellule non coesive, relativamente uniformi, di dimensioni medio-piccole, non differenziate. Di solito esordisce con emorragie disfunzionali o perdite vaginali e, raramente, con dolore addominale. Può associarsi alla sindrome di Lynch."},"nl":{"name":"Ongedifferentieerd carcinoom van corpus uteri","synonyms":["Endometriaal ongedifferentieerd carcinoom","Ongedifferentieerd carcinoom van baarmoederlichaam","Ongedifferentieerd carcinoom van endometrium"],"definition":"Niet-gedifferentieerd carcinoom van het corpus uteri is een zeldzame kanker van het baarmoederlichaam die voorkomt als een grote, polypoïde, intraluminale massa met necrose, bestaande uit kleine tot middelgrote, relatief uniforme cellen die verlies van cohesie en geen differentiatie vertonen. De ziekte manifesteert zich doorgaans met disfunctionele bloeding of vaginale afscheiding en, minder vaak, met buikpijn. Er werd associatie met syndroom van Lynch gerapporteerd."},"pt":{"name":"Carcinoma indiferenciado do corpo uterino"},"pl":{"name":"Niezróżnicowany rak trzonu macicy","synonyms":["Niezróżnicowany rak endometrium"]},"cs":{"name":"Nediferencovaný karcinom těla děložního","synonyms":["Endometriální nediferencovaný karcinom"]},"uk":{"name":"Недиференційована карцинома тіла матки","synonyms":["Недиференційована карцинома ендометрія"],"definition":"Undifferentiated carcinoma of the corpus uteri is a rare cancer of corpus uteri presenting as a large, polypoid, intraluminal mass with necrosis, composed of small to intermediate-size, relatively uniform, dyshesive cells displaying no differentiation. It usually presents with dysfunctional bleeding or vaginal discharge and, less often, abdominal pain. Association with Lynch syndrome was reported."},"zh":{"name":"子宫体未分化癌","synonyms":["子宫内膜未分化癌"],"definition":"子宫体未分化癌是一种罕见的子宫体癌，表现为一个大的、息肉状、伴有腔内坏死的肿块，由小至中等大小、相对均匀、未发育分化的细胞组成。本病通常表现为功能异常性出血或阴道分泌物，很少出现腹痛。曾报道与Lynch综合征相关。"},"tr":{"name":"Korpus uteri'nin farklılaşmamış karsinomu","synonyms":["Endometrial farklılaşmamış karsinom"]}},"xrefs":[{"source":"ICD-10","code":"C54","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"C54.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"C54.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"C54.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"C54.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"C54.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"2C76.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1473484566"},{"source":"MONDO","code":"0016267","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4707822","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":213569,"name":"Rare cancer of corpus uteri","classifications":[202,205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}