{"orpha":209959,"name":"Phacoanaphylactic uveitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Endophthalmitis phacoanaphylactica","Lens-induced endophthalmitis","Lens-induced iridocyclitis","Lens-induced uveitis","Phacoallergic endophthalmitis","Phacoantigenic endophthalmitis","Phako-anaphylactic endophthalmitis"],"definition":"A rare ophthalmic disorder characterized by a zonal granulomatous inflammatory reaction centered around the lens secondary to its traumatic rupture. Signs and symptoms include photophobia, ocular irritation or pain, blurred vision, redness, mutton-fat keratic precipitates, posterior synechiae, and sometimes hypopyon. Intraocular pressure may be elevated due to blockage of the trabecular meshwork by inflammatory cells or lens material.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-209959/","orphanet_url":"https://www.orpha.net/en/disease/detail/209959","names":{"fr":{"name":"Uvéite phacoanaphylactique","synonyms":["Endophtalmie phacoanaphylactique","Phacoanaphylaxie","Uvéite phacoantigénique"],"definition":"Maladie ophtalmique rare caractérisée par une réaction inflammatoire granulomateuse zonale centrée sur le cristallin, secondaire à sa rupture traumatique. Les signes et symptômes comprennent la photophobie, l'irritation ou la douleur oculaire, la vision trouble, la rougeur, les précipités kératiques dits « en graisse de mouton », les synéchies postérieures et parfois l'hypopion. La pression intra-oculaire peut être élevée en raison de l'obstruction du réseau trabéculaire par des cellules inflammatoires ou des cellules du cristallin."},"de":{"name":"Uveitis, phakoanaphylaktische","synonyms":["Endophthalmitis phacoanaphylactica","Linsen-abhängige Endophthalmitis","Linsen-induzierte Iridozyklitis","Linsen-induzierte Uveitis","Phakoallergische Endophthalmitis","Phakoanaphylaktische Endophthalmitis"],"definition":"Eine seltene Augenerkrankung, die durch eine zonale granulomatöse Entzündungsreaktion um die Linse herum gekennzeichnet ist, die durch eine traumatische Linsenruptur verursacht wird. Zu den Anzeichen und Symptomen gehören Lichtscheu, Augenreizung oder -schmerz, verschwommenes Sehen, Rötung, schmierige keratöse Ablagerungen, hintere Synechien und manchmal Hypopyon. Der Augeninnendruck kann aufgrund einer Verstopfung des Trabekelwerks durch Entzündungszellen oder Linsenmaterial erhöht sein."},"es":{"name":"Uveítis facoanafiláctica","synonyms":["Endoftalmitis facoalérgica","Endoftalmitis facoanafiláctica","Endoftalmitis facoantigénica","Endoftalmitis inducida por lentes","Iridociclitis inducida por lentes","Uveítis inducida por lentes"],"definition":"Es un trastorno oftalmológico poco frecuente caracterizado por una reacción inflamatoria granulomatosa zonal centrada alrededor del cristalino y secundaria a su rotura traumática. Los signos y síntomas incluyen fotofobia, irritación o dolor ocular, visión borrosa, enrojecimiento, precipitados queráticos ''en grasa de carnero'', sinequias posteriores y, en ocasiones, hipopion. La presión intraocular puede estar elevada debido al bloqueo de la red trabecular por células inflamatorias o material del cristalino."},"it":{"name":"Uveite facoanafilattica","synonyms":["Endoftalmite cristallino-indotta","Endoftalmite faco-anafilattica","Endoftalmite facoallergica","Endoftalmite facoanafilattica","Endoftalmite facoantigenica","Glaucoma facolitico","Iridociclite cristallino-indotta","Uveite cristallino-indotta"],"definition":"Si tratta di una malattia oculare rara, caratterizzata da una reazione infiammatoria granulomatosa localizzata attorno al cristallino, secondaria alla sua rottura traumatica. I segni clinici comprendono la fotofobia, l'irritazione o il dolore oculare, la visione offuscata, l'arrossamento, i precipitati cheratici a ''grasso di montone'', le sinechie posteriori e, talvolta, l'ipopion. La pressione intraoculare può essere elevata a causa del blocco della rete trabecolare da parte di cellule infiammatorie o di materiale del cristallino."},"nl":{"name":"Faco-anafylactische uveïtis","synonyms":["Endophthalmitis phacoanaphylactica","Faco-allergische endoftalmitis","Faco-anafylactische endoftalmitis","Faco-antigene endoftalmitis","Lens-geïnduceerde endoftalmitis","Lens-geïnduceerde iridocyclitis","Lens-geïnduceerde uveïtis"],"definition":"Een zeldzame aandoening van oog, gekarakteriseerd door zonale granulomateuze inflammatoire reactie gecentreerd rond de lens secundair aan traumatische ruptuur van lens. Verschijnselen en symptomen zijn onder meer fotofobie, irritatie van of pijn aan oog, troebel zicht, roodheid, 'mutton-fat' keratitische precipitaten, posterieure synechieën, en soms hypopyon. Intraoculaire druk kan verhoogd zijn door obstructie van trabeculair netwerk door inflammatoire cellen of materiaal van lens."},"pt":{"name":"Uveíte facoanafilática"},"pl":{"name":"Fakoanafilaktyczne zapalenie błony naczyniowej","synonyms":["Jaskra fakolityczna","Zapalenie błony naczyniowej pochodzenia soczewkowego","Zapalenie błony wewnętrzej fotoanafilaktyczne","Zapalenie błony wewnętrznej wywołane soczewkami","Zapalenie fotoalergiczne","Zapalenie tęczówki i ciała rzęskowego wywołane soczewkami"]},"cs":{"name":"Fakoanafylaktická uveitida","synonyms":["Fakoanafylaktická endoftalmitida","Fakoalergická endoftalmitida","Fakoantigenní endoftalmitida","Endoftalmitida vyvolaná čočkou","Iridocyklitida vyvolaná čočkou","Uveitida vyvolaná čočkou"]},"uk":{"name":"Факоанафілактичний увеїт","synonyms":["Ендофтальміт факоанафілактичний","Ендофтальміт, спричинений лінзами","Іридоцикліт, спричинений лінзами","Увеїт, спричинений лінзами","Факоалергічний ендофтальміт","Факоантигенний ендофтальміт","Фако-анафілактичний ендофтальміт"],"definition":"A rare ophthalmic disorder characterized by a zonal granulomatous inflammatory reaction centered around the lens secondary to its traumatic rupture. Signs and symptoms include photophobia, ocular irritation or pain, blurred vision, redness, mutton-fat keratic precipitates, posterior synechiae, and sometimes hypopyon. Intraocular pressure may be elevated due to blockage of the trabecular meshwork by inflammatory cells or lens material."},"zh":{"name":"晶状体过敏性葡萄膜炎","synonyms":["晶状体成分过敏性眼内炎"]},"tr":{"name":"Fakoanafilaktik üveit","synonyms":["Lens kaynaklı üveit","Lens kaynaklı iridosiklit","Lens kaynaklı endoftalmi","Fakoalerjik endoftalmi","Fakoantijenik endoftalmi","Endoftalmi fakoanafilaktika","Phako-anafilaktik endoftalmi"]}},"xrefs":[{"source":"ICD-10","code":"H20.2","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"9A96.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"2059865994"},{"source":"MONDO","code":"0016207","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1444621","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97966,"name":"Rare ophthalmic disorder"},"parents":[{"orpha":306648,"name":"Non-infectious anterior uveitis","classifications":[189]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2021-12-08","source":"32999673[PMID]_32808145[PMID]_31907641[PMID]","terms":[{"hpo":"HP:0200026","label":"Ocular pain","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0500081","label":"Pseudophakia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000572","label":"Visual loss","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011488","label":"Abnormal corneal endothelium morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000615","label":"Abnormal pupil morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012122","label":"Anterior uveitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000622","label":"Blurred vision","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030953","label":"Conjunctival hyperemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000491","label":"Keratitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000613","label":"Photophobia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012123","label":"Posterior uveitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025337","label":"Red eye","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0007773","label":"Vitreoretinopathy","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0030485","label":"Abnormal amplitude of pattern electroretinogram","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0030486","label":"Abnormal timing of pattern electroretinogram","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004327","label":"Abnormal vitreous humor morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025561","label":"Anterior chamber cells grade 1+","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031618","label":"Anterior chamber flare grade 1+","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025341","label":"Corneal keratic precipitates","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012040","label":"Corneal stromal edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011505","label":"Cystoid macular edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011886","label":"Hyphema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031615","label":"Hypopyon","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0040049","label":"Macular edema","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007906","label":"Ocular hypertension","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012121","label":"Panuveitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011484","label":"Posterior synechiae of the anterior chamber","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0008030","label":"Retinal arteritis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007917","label":"Tractional retinal detachment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011531","label":"Vitritis","frequency":"Occasional (29-5%)","criteria":null}]}}