{"orpha":206586,"name":"Neurolymphomatosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Neurolymphomatosis is a rare syndrome of peripheral and cranial nerve dysfunction in patients with hematologic malignancies, mostly non-Hodgkin's lymphoma or acute leukemia, characterized by painful or painless involvement of peripheral or cranial nerves or nerve roots. The clinical presentation is diverse depending on the site involved and includes plexopathy, mononeuritis multiplex, peripheral neuropathy, radiculopathy and cranial nerve palsies.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-206586/","orphanet_url":"https://www.orpha.net/en/disease/detail/206586","names":{"fr":{"name":"Neurolymphomatose","definition":"Un syndrome rare de dysfonction des nerfs crâniens et périphériques chez des patients présentant des tumeurs hématologiques, surtout une leucémie aigüe ou un lymphome non hodgkinien. Il se caractérise par l'atteinte (douloureuse ou non) des nerfs crâniens ou périphériques, ou des racines nerveuses. La présentation clinique varie selon le site affecté et inclut une plexopathie, une mononeuropathie multiple, une neuropathie périphérique, une radiculopathie et une paralysie des nerfs crâniens."},"de":{"name":"Neurolymphomatose","definition":"Die Neurolymphomatose ist ein seltenes Syndrom peripherer und kranialer Nervenfunktionsstörungen bei Patienten mit hämatologischen Malignomen, meist Non-Hodgkin-Lymphomen oder akuter Leukämie, gekennzeichnet durch schmerzhafte oder schmerzlose Beteiligung peripherer oder kranialer Nerven oder Nervenwurzeln. Die klinische Präsentation ist je nach betroffener Stelle vielfältig und umfasst Plexopathie, Mononeuritis multiplex, periphere Neuropathie, Radikulopathie und Hirnnervenlähmungen."},"es":{"name":"Neurolinfomatosis","definition":"Es un síndrome poco frecuente de disfunción de los nervios craneales y periféricos en pacientes con neoplasias hematológicas malignas, en su mayoría linfoma no Hodgkin o leucemia aguda. Está caracterizado por afectación dolorosa o indolora de nervios periféricos o craneales o raíces nerviosas. La presentación clínica es diversa según el sitio anatómico afectado e incluye plexopatía, mononeuritis múltiple, neuropatía periférica, radiculopatía y parálisis de los nervios craneales."},"it":{"name":"Neurolinfomatosi","definition":"La neurolinfomatosi è una malattia rara da disfunzione dei nervi periferici e cranici, che colpisce i pazienti affetti da tumori ematologici maligni, in particolare in linfoma non-Hodgkin o la leucemia acuta. La malattia è caratterizzata da un interessamento doloroso o indolore dei nervi periferici o cranici, oppure delle radici dei nervi. Il quadro clinico è variabile e dipende dall'area interessata; comprende la plessopatia, la mononeurite multipla, la neuropatia periferica, la radicolopatia e la paralisi dei nervi cranici."},"nl":{"name":"Neurolymfomatose","definition":"Neurolymfomatose is een zeldzaam syndroom met disfunctie van perifere en craniale zenuwen bij patiënten met hematologische maligniteiten, meestal non-Hodgkinlymfoom of acute leukemie, en wordt gekarakteriseerd door pijnlijke of pijnloze betrokkenheid van perifere of craniale zenuwen of zenuwwortels. Het klinisch beeld varieert naargelang de betrokken regio en omvat onder meer plexopathie, multipele mononeuropathie, perifere neuropathie, radiculopathie en hersenzenuwverlammingen."},"pt":{"name":"Neurolinfomatose"},"pl":{"name":"Neurolimfomatoza"},"cs":{"name":"Neurolymfomatóza"},"uk":{"name":"Нейролімфоматоз","definition":"Neurolymphomatosis is a rare syndrome of peripheral and cranial nerve dysfunction in patients with hematologic malignancies, mostly non-Hodgkin's lymphoma or acute leukemia, characterized by painful or painless involvement of peripheral or cranial nerves or nerve roots. The clinical presentation is diverse depending on the site involved and includes plexopathy, mononeuritis multiplex, peripheral neuropathy, radiculopathy and cranial nerve palsies."},"zh":{"name":"神经鞘瘤病","definition":"神经淋巴瘤病是一种罕见的外周神经和颅神经功能障碍综合征伴血液系统恶性肿瘤，多为非霍奇金淋巴瘤或急性白血病，其主要临床表现为外周神经、颅神经或神经根痛性或无痛性受累。临床表现因病变部位而异，包括神经丛病变、多发性单神经炎、周围神经病变、神经根病变和颅神经麻痹。"},"tr":{"name":"Nörolenfomatoz"}},"xrefs":[{"source":"ICD-10","code":"C96.7","qualifier":"NTBT","icd_relation":"attributed","validated":false},{"source":"ICD-10","code":"G63.1","qualifier":"NTBT","icd_relation":"attributed","validated":false},{"source":"ICD-11","code":"8C01.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"177999927"},{"source":"MONDO","code":"0016101","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D000077162","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4553088","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":207046,"name":"Malignant lymphoma with peripheral neuropathy","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}