{"orpha":2014,"name":"Cleft palate","type":"Clinical group","group":"Group of disorders","status":"active","flags":[],"synonyms":[],"definition":"A fissure type embryopathy that affects the soft and hard palate to varying degrees.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-2014/","orphanet_url":"https://www.orpha.net/en/disease/detail/2014","names":{"fr":{"name":"Fente du palais","synonyms":["Fente palatine"],"definition":"La fente vélo-palatine (FVP) est une embryopathie précoce de type fissuraire qui atteint de façon variable le voile musculaire du palais et le palais osseux."},"de":{"name":"Gaumenspalte","definition":"Die Gaumenspalte ist eine Spalten-Embryopathie, die in unterschiedlichem Ausmaß den weichen und harten Gaumen betrifft."},"es":{"name":"Paladar hendido","definition":"Es una embriopatía de tipo fisura que afecta de forma variable al paladar duro y al velo del paladar."},"it":{"name":"Palatoschisi","definition":"La palatoschisi è un'embriopatia che consiste in una fissurazione che interessa, in modo variabile, il palato duro e molle."},"nl":{"name":"Gespleten verhemelte","definition":"Een fissuur-embryopathie die het zachte en harde verhemelte treft in uiteenlopende mate."},"pt":{"name":"Fenda palatina","definition":"A fenda palatina é uma embriopatia tipo fissura que afeta o palato mole e duro em graus variados."},"pl":{"name":"Rozszczep podniebienia"},"cs":{"name":"Rozštěp patra"},"uk":{"name":"Розщеплення піднебіння","definition":"A fissure type embryopathy that affects the soft and hard palate to varying degrees."},"zh":{"name":"腭裂"},"tr":{"name":"Yarık dudak"}},"xrefs":[{"source":"OMIM","code":"119540","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"Q35","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"LA42","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"2129534948"},{"source":"MONDO","code":"0016064","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"16064","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D002972","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0008925","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"1896","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10009269","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":93890,"name":"Rare developmental defect during embryogenesis"},"parents":[{"orpha":155832,"name":"Rare head and neck malformation","classifications":[147]},{"orpha":68329,"name":"Rare maxillo-facial surgical disease","classifications":[209]}],"children":[{"orpha":99771,"name":"Bifid uvula","type":"Morphological anomaly"},{"orpha":101023,"name":"Cleft hard palate","type":"Morphological anomaly"},{"orpha":99772,"name":"Cleft velum","type":"Morphological anomaly"},{"orpha":664372,"name":"Soft and hard cleft palate","type":"Morphological anomaly"},{"orpha":155878,"name":"Submucosal cleft palate","type":"Morphological anomaly"}],"genes":[],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial","Not applicable"],"onset":["Antenatal","Neonatal"],"prevalence":[{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":53.6,"area":"Europe","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Europe","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":19.6,"area":"Austria","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2009[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Austria","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2009[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":40.8,"area":"Belgium","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Belgium","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":56.8,"area":"Croatia","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Croatia","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":127.6,"area":"Denmark","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":">1 / 1000","value":0.0,"area":"Denmark","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":25.5,"area":"France","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"France","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":47.5,"area":"Germany","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Germany","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":67.5,"area":"Hungary","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"6-9 / 10 000","value":0.0,"area":"Hungary","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":54.2,"area":"Ireland","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Ireland","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":39.6,"area":"Italy","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Italy","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":74.7,"area":"Malta","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"6-9 / 10 000","value":0.0,"area":"Malta","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":11.7,"area":"Netherlands","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Netherlands","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":65.4,"area":"Norway","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"6-9 / 10 000","value":0.0,"area":"Norway","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":36.5,"area":"Poland","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Poland","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":14.2,"area":"Portugal","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Portugal","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":30.7,"area":"Spain","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Spain","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2010[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":25.1,"area":"Switzerland","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Switzerland","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":60.2,"area":"United Kingdom","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"6-9 / 10 000","value":0.0,"area":"United Kingdom","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":57.2,"area":"Ukraine","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Ukraine","status":"Validated","source":"EUROCAT European surveillance of congenital anomalies 2011[OTHER]"},{"type":"Prevalence at birth","qualification":"Value and class","class":">1 / 1000","value":101.2,"area":"Australia","status":"Validated","source":"23371924[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":">1 / 1000","value":0.0,"area":"Australia","status":"Not yet validated","source":"23371924[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":52.0,"area":"Chile","status":"Validated","source":"11372296[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Chile","status":"Not yet validated","source":"11372296[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":27.0,"area":"Sudan","status":"Validated","source":"15854114[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Sudan","status":"Not yet validated","source":"15854114[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":26.0,"area":"Iran, Islamic Republic of","status":"Validated","source":"20648890[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Iran, Islamic Republic of","status":"Not yet validated","source":"20648890[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":27.0,"area":"Mexico","status":"Validated","source":"8442867[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Mexico","status":"Not yet validated","source":"8442867[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-9 / 100 000","value":4.0,"area":"Bolivia","status":"Validated","source":"14989684[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"1-9 / 100 000","value":0.0,"area":"Bolivia","status":"Not yet validated","source":"14989684[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"6-9 / 10 000","value":68.0,"area":"Specific population","status":"Validated","source":"15516165[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"6-9 / 10 000","value":0.0,"area":"Specific population","status":"Validated","source":"15516165[PMID]"},{"type":"Prevalence at birth","qualification":"Value and class","class":"1-5 / 10 000","value":40.0,"area":"Taiwan, Province of China","status":"Validated","source":"23555592[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"1-5 / 10 000","value":0.0,"area":"Taiwan, Province of China","status":"Not yet validated","source":"23555592[PMID]"}],"phenotypes":null}