{"orpha":199323,"name":"Endophthalmitis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare ophthalmic disorder characterized by inflammation involving the vitreous and/or aqueous humors, usually due to bacterial or fungal infection. It may arise endogenously from hematogenous spread of the infectious agent, or exogenously after direct inoculation, and can take an acute or chronic course. Clinical signs and symptoms include progressive vitritis, hypopyon, reduced or blurred vision, red eye, pain, and lid swelling. The condition may be complicated by panophthalmitis, corneal infiltration and perforation, affection of orbital structures, and phthisis bulbi.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-199323/","orphanet_url":"https://www.orpha.net/en/disease/detail/199323","names":{"fr":{"name":"Endophtalmie","definition":"Maladie ophtalmique rare caractérisée par une inflammation infectant les humeurs vitrée et/ou aqueuse, généralement due à une infection bactérienne ou fongique. De forme aiguë ou chronique, elle peut survenir de manière endogène, par propagation hématogène de l'agent infectieux, ou de manière exogène, après inoculation directe. Les signes cliniques et symptômes sont une vitrite progressive, un hypopion, une vision réduite ou floue, un oeil rouge, une douleur et un gonflement des paupières. Les complications peuvent être une panophtalmie, une infiltration et une perforation de la cornée, une atteinte des structures orbitaires et une phtisie bulbaire."},"de":{"name":"Endophthalmitis","definition":"Eine seltene Augenerkrankung, die durch eine Entzündung des Glaskörpers und/oder des Kammerwassers gekennzeichnet ist und in der Regel auf eine bakterielle oder Pilzinfektion zurückzuführen ist. Sie kann endogen durch hämatogene Ausbreitung des Infektionserregers oder exogen nach direkter Inokulation entstehen und kann akut oder chronisch verlaufen. Zu den klinischen Anzeichen und Symptomen gehören fortschreitende Vitritis, Hypopyon, vermindertes oder verschwommenes Sehen, rote Augen, Schmerzen und Lidschwellungen. Die Erkrankung kann durch Panophthalmitis, Hornhautinfiltration und -perforation, Befall der Orbitalstrukturen und Phthisis bulbi kompliziert werden."},"es":{"name":"Endoftalmitis","definition":"Es un trastorno oftálmico poco frecuente caracterizado por una inflamación que afecta al humor vítreo y/o acuoso, generalmente debido a una infección bacteriana o micótica. Puede originarse de forma endógena por diseminación hematógena del agente infeccioso, o de forma exógena después de la inoculación directa, y puede seguir un curso agudo o crónico. Los signos y síntomas clínicos incluyen vitritis progresiva, hipopion, visión reducida o borrosa, ojos rojos, dolor e hinchazón del párpado. La afección puede complicarse por panoftalmitis, infiltración y perforación de la córnea, así como por afectación de las estructuras orbitarias y ptisis bulbi."},"it":{"name":"Endoftalmite","definition":"Si tratta di una malattia oculare rara, caratterizzata dall'infiammazione dell'umor vitreo e/o dell'umor acqueo, di solito secondaria a un'infezione batterica o fungina. Può originare per via endogena dalla diffusione attraverso il sangue dell'agente infettivo, oppure per via esogena dopo un'inoculazione diretta. Il decorso può essere acuto o cronico. I segni clinici comprendono la vitreite progressiva, l'ipopion, la riduzione o l'annebbiamento della vista, gli occhi arrossati, il dolore e il gonfiore delle palpebre. Può associarsi a complicanze come la panoftalmite, l'infiltrazione e la perforazione della cornea, l'interessamento delle strutture orbitali e la ftisi del bulbo."},"nl":{"name":"Endoftalmitis","definition":"Een zeldzame aandoening van oog, gekarakteriseerd door inflammatie van glasvocht en/of kamervocht, meestal vanwege bacteriële of fungale infectie. De aandoening kan endogeen ontstaan door hematogene verspreiding van het infectieuze agens, of exogeen na directe inoculatie, en kan een acuut of chronisch verloop aannemen. Klinische verschijnselen en symptomen zijn onder meer progressieve vitritis, hypopyon, verminderd of troebel zicht, rood oog, pijn, en zwelling van ooglid. De aandoening kan gecompliceerd worden door panoftalmitis, infiltratie en perforatie van hoornvlies, aantasting van orbitale structuren, en phthisis bulbi (verschrompelen van oogbol)."},"pt":{"name":"Endoftalmite"},"pl":{"name":"Zapalenie wnętrza gałki ocznej"},"cs":{"name":"Endoftalmitida"},"uk":{"name":"Ендофтальміт","definition":"A rare ophthalmic disorder characterized by inflammation involving the vitreous and/or aqueous humors, usually due to bacterial or fungal infection. It may arise endogenously from hematogenous spread of the infectious agent, or exogenously after direct inoculation, and can take an acute or chronic course. Clinical signs and symptoms include progressive vitritis, hypopyon, reduced or blurred vision, red eye, pain, and lid swelling. The condition may be complicated by panophthalmitis, corneal infiltration and perforation, affection of orbital structures, and phthisis bulbi."},"zh":{"name":"眼内炎","definition":"眼内炎是一种罕见的以玻璃体和（或）房水炎症为特征的眼科疾病，由于细菌或真菌感染所致，是血源性传播或接种疫苗后引起的内源性疾病，呈急性或慢性病程。其主要临床表现和体征为进行性玻璃体炎、眼前房积脓、视力下降或模糊、红眼、疼痛和眼睑肿胀，可能并发全眼球炎、角膜浸润穿孔、眼眶感染和眼球结核。"},"tr":{"name":"Endoftalmit"}},"xrefs":[{"source":"ICD-10","code":"H44.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"H44.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"9C21","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1211141166"},{"source":"MONDO","code":"0016047","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D009877","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0014236","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10014801","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97966,"name":"Rare ophthalmic disorder"},"parents":[{"orpha":519329,"name":"Rare disorder involving multiple structures of the eye","classifications":[189]}],"children":[{"orpha":279888,"name":"Acute endophthalmitis","type":"Clinical subtype"},{"orpha":279891,"name":"Chronic endophthalmitis","type":"Clinical subtype"}],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}