{"orpha":182,"name":"Chromomycosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Chromoblastomycosis"],"definition":"Chromomycosis is a chronic cutaneous and subcutaneous fungal infection, found mainly in subtropical and tropical areas (in soil and plant debris and transmitted by traumatic inoculation), and characterized clinically by slow growing, verrucous nodules, squamous plaques, or chronic limited lesions which are most commonly found on the lower limbs and which are characterized histologically by the presence of muriform cells. It is caused by dematiaceous fungi, with the main etiological agents being <i>Fonsecaea pedrosoi</i>, <i>Phialophora verrucosa</i> and <i>Cladophialophora carrionii</i>. Rarely, it can be caused by <i>Rhinocladiella aquaspersa</i>.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-182/","orphanet_url":"https://www.orpha.net/en/disease/detail/182","names":{"fr":{"name":"Chromomycose","synonyms":["Chromoblastomycose"],"definition":"La chromomycose est une infection fongique chronique cutanée et sous-cutanée principalement présente dans les régions tropicales et sous-tropicales (dans la terre et les déchets végétaux, avec une transmission par inoculation traumatique), et caractérisée cliniquement par un développement lent, des nodules verruqueux, des plaques squameuses, ou des lésions limitées chroniques le plus souvent observées sur les membres inférieurs et histologiquement caractérisées par la présence de cellules muriformes. Elle est provoquée par les dématiés, avec pour principaux agents pathogènes <i>Fonsecaea pedrosoi</i>, <i>Phialophora verrucosa</i> et <i>Cladophialophora carrionii</i>. Plus rarement, elle peut être causée par <i>Rhinocladiella aquaspersa</i>."},"de":{"name":"Chromomykose","synonyms":["Chromoblastomykose"],"definition":"Die Chromomykose ist eine chronische Pilzinfektion der Haut und Schleimhäute, die hauptsächlich in tropischen und subtropischen Gebieten auftritt (im Erdboden sowie Pflanzenabfällen und übertragen durch Verletzungen). Ihre klinischen Kennzeichen sind langsames Wachstum, warzenartige Knötchen, Hautabschuppungen oder chronische abgegrenze Hautläsionen i. d. R. auf den unteren Extremitäten, die sich histologisch durch ziegelsteinähnliche Zellen auszeichnen. Verursacht wird sie durch Dematiazeen, wobei die Haupterreger <i>Fonsecaea pedrosoi</i>, <i>Phialophora verrucosa</i> und <i>Cladophialophora carrionii</i> sind. Nur selten kann sie durch <i>Rhinocladiella aquaspersa</i> verursacht werden."},"es":{"name":"Cromomicosis","synonyms":["Cromoblastomicosis"],"definition":"La cromomicosis es una infección fúngica cutánea y subcutánea crónica que se observa principalmente en las zonas tropicales y subtropicales (el hongo se encuentra en el suelo y en los desechos vegetales y es transmitido mediante inoculación traumática) y que se caracteriza clínicamente por la presencia de nódulos verrugosos de crecimiento lento, placas escamosas o lesiones crónicas limitadas que se localizan más habitualmente en las extremidades inferiores y se caracterizan histológicamente por la presencia de células muriformes. Está causada por hongos dematiáceos, de entre los cuales, los principales agentes etiológicos son <i>Fonsecaea pedrosoi</i>, <i>Phialophora verrucosa</i> y <i>Cladophialophora carrionii</i>. En raras ocasiones puede estar causada por <i>Rhinocladiella aquaspersa</i>."},"it":{"name":"Cromomicosi","synonyms":["Cromoblastomicosi"],"definition":"La cromomicosi è un'infezione micotica cutanea e sottocutanea cronica, descritta essenzialmente nelle aree subtropicali e tropicali (nel terreno e nei residui vegetali e trasmessa attraverso un'inoculazione traumatica), caratterizzata clinicamente da crescita lenta, noduli verrucosi, placche squamose o lesioni limitate croniche (più spesso agli arti inferiori), caratterizzate, dal punto di vista istologico, dalla presenza di cellule muriformi. È causata da funghi demaziacei; i principali agenti eziologici sono <i>Fonsecaea pedrosoi</i>, <i>Phialophora verrucosa</i> e <i>Cladophialophora carrionii</i>. Raramente può essere causata da <i>Rhinocladiella aquaspersa</i>."},"nl":{"name":"Chromomycosis","synonyms":["Chromoblastomycosis"],"definition":"Chromomycosis is een chronische cutane en subcutane schimmelinfectie, die voornamelijk voorkomt in subtropische en tropische gebieden (in de bodem en plantenresten en overgedragen door inoculatie bij trauma), en die klinisch gekenmerkt wordt door traag groeiende verruceuze nodules, squameuze plaques, of chronische gelimiteerde laesies die het meest voorkomen op de onderste ledematen en die histologisch gekenmerkt zijn door de aanwezigheid van muriforme cellen. De ziekte wordt veroorzaakt door dematiaceuze schimmels, waarbij de belangrijkste etiologische agentia <i>Fonsecaea pedrosoi</i>, <i>Phialophora verrucosa</i> en <i>Cladophialophora carrionii</i> zijn. Zelden kan het ook veroorzaakt worden door <i>Rhinocladiella aquaspersa</i>."},"pt":{"name":"Cromomicose"},"pl":{"name":"Chromomikoza","synonyms":["Chromoblastomycosis"]},"cs":{"name":"Chromomykóza","synonyms":["Chromoblastomykóza"]},"uk":{"name":"Хромомікоз","synonyms":["Хромобластомікоз"],"definition":"Chromomycosis is a chronic cutaneous and subcutaneous fungal infection, found mainly in subtropical and tropical areas (in soil and plant debris and transmitted by traumatic inoculation), and characterized clinically by slow growing, verrucous nodules, squamous plaques, or chronic limited lesions which are most commonly found on the lower limbs and which are characterized histologically by the presence of muriform cells. It is caused by dematiaceous fungi, with the main etiological agents being <i>Fonsecaea pedrosoi</i>, <i>Phialophora verrucosa</i> and <i>Cladophialophora carrionii</i>. Rarely, it can be caused by <i>Rhinocladiella aquaspersa</i>."},"zh":{"name":"色素性真菌病","synonyms":["着色真菌病"]},"tr":{"name":"Kromomikoz","synonyms":["Kromoblastomikoz"]}},"xrefs":[{"source":"ICD-10","code":"B43.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B43.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B43.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B43.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B43.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F24","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1438584733"},{"source":"MONDO","code":"0015908","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D002862","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0008582","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"1319","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10008803","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163591,"name":"Rare mycosis","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-04-15","source":"27856522[PMID]_30066754[PMID]_30113072[PMID]","terms":[{"hpo":"HP:0002814","label":"Abnormality of the lower limb","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000989","label":"Pruritus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001760","label":"Abnormal foot morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025528","label":"Annular cutaneous lesion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000969","label":"Edema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025475","label":"Erythematous macule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025474","label":"Erythematous plaque","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000962","label":"Hyperkeratosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0045059","label":"Hyperkeratotic papule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0040009","label":"Hyperparakeratosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001004","label":"Lymphedema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003550","label":"Predominantly lower limb lymphedema","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025527","label":"Serpiginous cutaneous lesion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001482","label":"Subcutaneous nodule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012500","label":"Verrucous papule","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002817","label":"Abnormality of the upper limb","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000987","label":"Atypical scarring of skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001053","label":"Hypopigmented skin patches","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031842","label":"Lymphangiectasis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002718","label":"Recurrent bacterial infections","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011276","label":"Vascular skin abnormality","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002088","label":"Abnormal lung morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000163","label":"Abnormal oral cavity morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031013","label":"Ankylosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000656","label":"Ectropion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0500043","label":"Eyelid retraction","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0011334","label":"Facial shape deformation","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002721","label":"Immunodeficiency","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000491","label":"Keratitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001097","label":"Keratoconjunctivitis sicca","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007606","label":"Multiple cutaneous malignancies","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002797","label":"Osteolysis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002860","label":"Squamous cell carcinoma","frequency":"Very rare (<4-1%)","criteria":null}]}}