{"orpha":180267,"name":"Giant adenofibroma of the breast","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Giant adenofibroma of the breast is a rare, benign, fibroepithelial tumor which usually manifests as a unilateral, painless, firm, mobile, slow-growing mass in the breast that measures more than 5 cm. It can be associated with significant asymmetry and/or deformity of the breast and hormonal changes (e.g. puberty, pregnancy, oral contraceptives) can lead to its marked enlargement.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-180267/","orphanet_url":"https://www.orpha.net/en/disease/detail/180267","names":{"fr":{"name":"Adénofibrome géant du sein","definition":"L'adénofibrome géant du sein est une tumeur fibroépithéliale bénigne et rare qui se manifeste généralement par une masse ferme, mobile, indolore, unilatérale et lentement progressive dans le sein, et mesurant plus de 5 cm. Il peut être associé à une asymétrie significative et/ou une déformation du sein, et des changements hormonaux (puberté, grossesse, prise de contraceptifs oraux) peuvent conduire à son élargissement prononcé."},"de":{"name":"Riesenfibroadenom der Brust","definition":"Das Riesenadenofibrom der Brust ist ein seltener, gutartiger, fibroepithelialer Tumor, der sich meist als einseitige, schmerzlose, feste, bewegliche, langsam wachsende Masse in der Brust manifestiert, die mehr als 5 cm misst. Er kann mit einer signifikanten Asymmetrie und/oder Deformität der Brust einhergehen und hormonelle Veränderungen (z. B. Pubertät, Schwangerschaft, orale Kontrazeptiva) können zu seiner deutlichen Vergrößerung führen."},"es":{"name":"Fibroadenoma gigante de mama","definition":"El adenofibroma gigante de mama es un tumor fibroepitelial benigno poco frecuente que suele manifestarse como una masa unilateral >5 cm, indolora, firme, móvil y de crecimiento lento en la mama. Puede asociarse a una asimetría y/o deformación de la mama importante, y los cambios hormonales (como la pubertad, el embarazo, los anticonceptivos orales) pueden provocar un notable aumento."},"it":{"name":"Fibroadenoma gigante della mammella","definition":"Il fibroadenoma gigante della mammella è un tumore fibroepiteliale benigno raro; di solito esordisce come massa monolaterale, indolore, solida e mobile che cresce lentamente nel seno e misura più di 5 cm. Può comportare una marcata asimmetria e/o deformità del seno; le variazioni dei livelli ormonali (pubertà, gravidanza, contraccettivi orali) possono causare un marcato ingrandimento della massa."},"nl":{"name":"Gigantisch adenofibroom van borst","synonyms":["Reuzenfibroadenoom van borst"],"definition":"Zeer groot adenofibroom van de borst is een zeldzame, goedaardige, fibro-epitheliale tumor die zich meestal manifesteert als een unilateraal, pijnloos, stevig, mobiel, traag groeiend gezwel in de borst met een omvang groter dan 5 cm. Het kan geassocieerd zijn met significante asymmetrie en/of misvorming van de borst, en hormonale veranderingen (e.g. puberteit, zwangerschap, orale contraceptiva) kunnen leiden tot een duidelijke vergroting van het gezwel."},"pt":{"name":"Adenofibroma gigante da mama"},"pl":{"name":"Ogromny gruczolakowłókniak piersi"},"cs":{"name":"Obrovský fibroadenom prsu"},"uk":{"name":"Гігантська аденофіброма молочної залози","definition":"Giant adenofibroma of the breast is a rare, benign, fibroepithelial tumor which usually manifests as a unilateral, painless, firm, mobile, slow-growing mass in the breast that measures more than 5 cm. It can be associated with significant asymmetry and/or deformity of the breast and hormonal changes (e.g. puberty, pregnancy, oral contraceptives) can lead to its marked enlargement."},"zh":{"name":"巨型乳腺纤维瘤","definition":"乳腺巨大腺纤维瘤是一种罕见的良性纤维上皮肿瘤，其主要临床表现为单侧无痛性肿块，质硬，可移动，生长缓慢，大小超过5厘米。可能与乳房明显不对称和（或）畸形有关，激素变化（e.g.青春期、怀孕、口服避孕药）可导致乳房明显增大。"},"tr":{"name":"Memenin dev adenofibromu"}},"xrefs":[{"source":"ICD-10","code":"D24","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2F30.5","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1030551440"},{"source":"MONDO","code":"0015872","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"15872","qualifier":"E","icd_relation":null,"validated":true},{"source":"MONDO","code":"4150","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0346157","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":180253,"name":"Rare benign breast tumor","classifications":[202,205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}