{"orpha":180247,"name":"Vaginal carcinoma","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Vaginal malignant epithelial tumor"],"definition":"A group of rare vaginal tumors comprising HPV-associated and HPV-independent squamous cell carcinoma, glandular tumors (including HPV-associated adenocarcinoma, endometrioid carcinoma, clear cell carcinoma, gastric type and intestinal type mucinous carcinoma, and mesonephric adenocarcinoma), adenocarcinoma of Skene gland origin, adenosquamous carcinoma, and adenoid basal carcinoma. Depending on the type of tumor and disease stage, patients may present with symptoms related to a vaginal mass, vaginal bleeding and/or discharge, postcoital bleeding, urinary symptoms, pelvic pain, and a foreign body sensation within the vagina.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-180247/","orphanet_url":"https://www.orpha.net/en/disease/detail/180247","names":{"fr":{"name":"Carcinome du vagin","synonyms":["Tumeur épithéliale maligne du vagin"],"definition":"Groupe de tumeurs rares du vagin constitué des carcinomes épidermoïdes associés ou non aux papillomavirus humains (HPV), des tumeurs glandulaires (à savoir adénocarcinome associé aux HPV, adénocarcinome endométrioïde, carcinome à cellules claires, carcinome mucineux de type gastrique et de type intestinal, et adénocarcinome mésonéphrique), des adénocarcinomes prenant naissance dans les glandes de Skene, des carcinomes adénosquameux et des carcinomes basocellulaires adénoïdes. En fonction du type et du stade de la tumeur, les patientes peuvent présenter des symptômes liés à la présence d'une masse vaginale, des saignements vaginaux et/ou un écoulement vaginal, des saignements post-coïtaux, des symptômes urinaires, des douleurs pelviennes et la sensation d'avoir un corps étranger dans le vagin."},"de":{"name":"Vaginalkarzinom","synonyms":["Vaginaltumor, epithelialer maligner"],"definition":"Eine Gruppe seltener Vaginaltumoren, zu denen HPV-assoziierte und HPV-unabhängige Plattenepithelkarzinome, Drüsentumoren (einschließlich HPV-assoziierter Adenokarzinome, endometrioider Karzinome, klarzelliger Karzinome, muzinöser Karzinome des Magen-Darm-Trakts und mesonephrischer Adenokarzinome), Adenokarzinome der Skene-Drüse, adenosquamöse Karzinome und adenoide Basalzellkarzinome gehören. Abhängig von der Art des Tumors und dem Krankheitsstadium können bei Patienten Symptome auftreten, die mit einer Raumforderung in der Vagina, Vaginalblutungen und/oder -ausfluss, postkoitalen Blutungen, Harnbeschwerden, Unterleibsschmerzen und einem Fremdkörpergefühl in der Vagina zusammenhängen."},"es":{"name":"Carcinoma de vagina","synonyms":["Tumor epitelial maligno de vagina"],"definition":"Es un grupo de tumores vaginales poco frecuente que comprende el carcinoma de células escamosas, tanto asociado como independiente del VPH, tumores glandulares (incluyendo el adenocarcinoma asociado al VPH, el carcinoma endometrioide, el carcinoma de células claras, el carcinoma mucinoso de tipo gástrico e intestinal y el adenocarcinoma mesonéfrico), el adenocarcinoma de la glándula de Skene, el carcinoma adenoescamoso y el carcinoma adenoide basal. Dependiendo del tipo de tumor y del estadío de la enfermedad, las pacientes pueden presentar síntomas asociados a una masa vaginal, sangrado y/o secreción vaginal, sangrado postcoital, síntomas urinarios, dolor pélvico y sensación de cuerpo extraño en la vagina."},"it":{"name":"Carcinoma della vagina","synonyms":["Tumore epiteliale maligno della vagina"],"definition":"Si tratta di un gruppo di tumori rari della vagina, che comprendono il carcinoma squamocellulare associato all'HPV e indipendente dall'HPV, i tumori ghiandolari (tra i quali l'adenocarcinoma associato all'HPV, il carcinoma endometrioide, il carcinoma a cellule chiare, il carcinoma mucinoso di tipo gastrico e di tipo intestinale, e l'adenocarcinoma del mesonefro), l'adenocarcinoma che origina dalle ghiandole di Skene, il carcinoma adenosquamoso e il carcinoma adenoideo basale. A seconda del tipo di tumore e dello stadio della malattia, le pazienti possono presentare i sintomi correlati alla presenza di una massa vaginale, emorragia e/o secrezione vaginale, sanguinamento postcoitale, sintomi urinari, dolore pelvico e sensazione di corpo estraneo all'interno della vagina."},"nl":{"name":"Vaginaal carcinoom","synonyms":["Kwaadaardige epitheliale vaginale tumor","Maligne epitheliale vaginale tumor"],"definition":"Een groep van zeldzame tumoren van vagina bestaande uit HPV-geassocieerd en HPV-onafhankelijk plaveiselcelcarcinoom, glandulaire tumoren (waaronder HPV-geassocieerd adenocarcinoom, endometrioïd carcinoom, heldercellig carcinoom, gastrisch type en intestinaal type mucineus carcinoom, en mesonefrisch adenocarcinoom), adenocarcinoom afkomstig van Skene-klieren, adenosquameus carcinoom, en adenoïd basaalcelcarcinoom. Afhankelijk van het type van de tumor en het stadium van de ziekte kunnen patiënten zich presenteren met symptomen gerelateerd aan een vaginale massa, vaginale bloeding en/of afscheiding, postcoïtale bloeding, urinaire symptomen, pijn in bekken, en een gevoel van corpus alienum in de vagina."},"pt":{"name":"Cancro vaginal"},"pl":{"name":"Rak pochwy","synonyms":["Złośliwy rak nabłonka pochwy"]},"cs":{"name":"Karcinom pochvy","synonyms":["Zhoubný epiteliální nádor pochvy"]},"uk":{"name":"Карцинома піхви","synonyms":["Злоякісна епітеліальна пухлина піхви"],"definition":"A group of rare vaginal tumors comprising HPV-associated and HPV-independent squamous cell carcinoma, glandular tumors (including HPV-associated adenocarcinoma, endometrioid carcinoma, clear cell carcinoma, gastric type and intestinal type mucinous carcinoma, and mesonephric adenocarcinoma), adenocarcinoma of Skene gland origin, adenosquamous carcinoma, and adenoid basal carcinoma. Depending on the type of tumor and disease stage, patients may present with symptoms related to a vaginal mass, vaginal bleeding and/or discharge, postcoital bleeding, urinary symptoms, pelvic pain, and a foreign body sensation within the vagina."},"zh":{"name":"阴道癌","synonyms":["阴道恶性上皮肿瘤"]},"tr":{"name":"Vajinal karsinom","synonyms":["Vajinal habis epitel tümörü"]}},"xrefs":[{"source":"ICD-10","code":"C52","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2C71","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"798353632"},{"source":"MONDO","code":"0015867","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0262659","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9348","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":180312,"name":"Rare vulvovaginal tumor","classifications":[202,205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult","Elderly"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.36,"area":"Worldwide","status":"Validated","source":"38924674[PMID]_ORPHANET"}],"phenotypes":null}