{"orpha":178475,"name":"Wound botulism","type":"Etiological subtype","group":"Subtype of disorder","status":"active","flags":[],"synonyms":["Cutaneous infectious botulism","Cutaneous toxin-mediated botulism","Inoculation botulism","Skin infectious botulism","Skin toxin-mediated botulism"],"definition":"Wound botulism is a rare infectious form of botulism, a rare acquired neuromuscular junction disease with descending flaccid paralysis due to botulinum neurotoxins (BoNTs), produced after infection of wounds by <i>Clostridium botulinum</i>.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-178475/","orphanet_url":"https://www.orpha.net/en/disease/detail/178475","names":{"fr":{"name":"Botulisme par blessure","synonyms":["Botulisme des plaies","Botulisme par inoculation","Botulisme par toxi-infection cutanée"],"definition":"Le botulisme par blessure est une forme toxi-infectieuse rare du botulisme , une maladie acquise rare de la jonction neuromusculaire avec paralysie flasque descendante due à la neurotoxine botulique (BoNT), produite par une souche de <i>Clostridium botulinum</i> infectant une plaie."},"de":{"name":"Wundbotulismus","synonyms":["Botulismus, infektiöser kutaner","Impfbotulismus","Kutaner Toxin-vermittelter Botulismus"],"definition":"Der Wundbotulismus ist eine seltene infektiöse Form des Botulismus, einer erworbenen Störung der Muskelendplatte mit absteigender schlaffer Parese, verursacht durch Botulinum-Neurotoxine (BoNTs) nach Infektion von Wunden mit Clostridium botulinum."},"es":{"name":"Botulismo por herida","synonyms":["Botulismo cutáneo mediado por toxina","Botulismo por infecciones de piel","Botulismo por infección cutánea","Botulismo por inoculación","Botulismo por toxiinfección de la piel"],"definition":"El botulismo por herida es una forma infecciosa rara de botulismo (ver término), una enfermedad rara adquirida de la unión neuromuscular con parálisis flácida descendente causada por la neurotoxina botulínica (BoNT), y producida tras la infección de una herida por <i>Clostridium botulinum</i>."},"it":{"name":"Botulismo da ferita","synonyms":["Botulismo cutaneo tossino-mediato","Botulismo da inoculazione","Botulismo infettivo cutaneo","Botulismo infettivo della cute","Botulismo tossino-mediato della cute"]},"nl":{"name":"Wondbotulisme","synonyms":["Cutaan infectieus botulisme","Cutaan toxine-gemedieerd botulisme","Infectieus botulisme van huid","Inoculatiebotulisme","Toxine-gemedieerd botulisme van huid"],"definition":"Wondbotulisme is een zeldzame infectieuze vorm van botulisme, een zeldzame verworven aandoening van neuromusculaire overgang met afdalende slappe paralyse veroorzaakt door botuline-neurotoxinen (BoNT's), geproduceerd na infectie van een wonde door <i>Clostridium botulinum</i>."},"pt":{"name":"Botulismo de ferida","definition":"O botulismo de feridas é uma forma infecciosa rara de botulismo (ver este termo), uma doença rara adquirida da junção neuromuscular com paralisia flácida descendente causada por neurotoxinas botulínicas (BoNTs), produzidas após a infecção de feridas por <i> Clostridium botulinum </ i>."},"pl":{"name":"Botulizm przyranny","synonyms":["Infekcja skóry botulinowa"]},"cs":{"name":"Ranný botulismus","synonyms":["Inokulační botulismus","Kožní infekční botulismus","Kožní botulismus způsobený toxinem"]},"uk":{"name":"Рановий ботулізм","synonyms":["Шкірний інфекційний ботулізм","Ботулізм, опосередкований шкірним токсином","Інєкційний ботулізм","Шкірний інфекційний ботулізм","Ботулізм, опосередкований шкірним токсином"],"definition":"Wound botulism is a rare infectious form of botulism (see this term), a rare acquired neuromuscular junction disease with descending flaccid paralysis due to botulinum neurotoxins (BoNTs), produced after infection of wounds by <i>Clostridium botulinum</i>."},"zh":{"name":"伤口型肉毒中毒","synonyms":["皮肤毒素介导肉毒中毒"],"definition":"伤口肉毒杆菌中毒是一种罕见的感染性肉毒杆菌病（见该术语），一种罕见的获得性神经肌肉接头疾病，由于肉毒杆菌感染伤口后所致，其主要临床表现为肉毒杆菌神经毒素（BoNTs）引起的下行性弛缓性麻痹。"},"tr":{"name":"Yara botulizmi","synonyms":["Aşılama botulizmi","Enfeksiyöz deri botulizmi","Deri toksini aracılı botulizm","Kutanöz enfeksiyöz botulizm","Kutanöz toksin aracılı botulizm"]}},"xrefs":[{"source":"ICD-10","code":"A05.1","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1A11.1","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1674998448"},{"source":"MONDO","code":"0015803","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C1306794","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":230800,"name":"Toxin-mediated infectious botulism","classifications":[181,189,203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.1,"area":"Europe","status":"Validated","source":"[EXPERT]_Center for Diseases Control and Prevention[OTHER]_ ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0100021","label":"Cerebral palsy","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002019","label":"Constipation","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0006597","label":"Diaphragmatic paralysis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000651","label":"Diplopia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001260","label":"Dysarthria","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002015","label":"Dysphagia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0011499","label":"Mydriasis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000508","label":"Ptosis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002094","label":"Dyspnea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002747","label":"Respiratory insufficiency due to muscle weakness","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000016","label":"Urinary retention","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001695","label":"Cardiac arrest","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001945","label":"Fever","frequency":"Occasional (29-5%)","criteria":null}]}}