{"orpha":168999,"name":"Malignant melanoma of the mucosa","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, aggressive, neoplastic disease characterized by the presence of a melanocyte tumor that develops in any mucosal membrane. Clinical manifestations vary depending on the site of occurrence.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-168999/","orphanet_url":"https://www.orpha.net/en/disease/detail/168999","names":{"fr":{"name":"Mélanome malin muqueux","definition":"Maladie néoplasique rare et agressive caractérisée par la présence d'une tumeur mélanocytaire qui se développe dans toute membrane muqueuse. Les manifestations cliniques varient en fonction du site d'apparition."},"de":{"name":"Malignes Melanom der Mukosa"},"es":{"name":"Melanoma maligno mucoso","synonyms":["Melanoma maligno de mucosa"],"definition":"Es una enfermedad neoplásica agresiva y poco frecuente caracterizada por la presencia de un tumor melanocítico en cualquier membrana mucosa. Las manifestaciones clínicas varían según la localización del tumor."},"it":{"name":"Melanoma maligno della mucosa","definition":"È una neoplasia rara e aggressiva caratterizzata dalla presenza di un tumore melanocitico che si sviluppa sulle mucose. I segni clinici variano a seconda del sito di insorgenza."},"nl":{"name":"Maligne melanoom van mucosa","synonyms":["Kwaadaardig melanoom van slijmvlies"],"definition":"Een zeldzame, agressieve, neoplastische ziekte gekarakteriseerd door de aanwezigheid van een melanocytaire tumor die ontwikkelt in om het even welk slijmvlies Klinische manifestaties variëren afhankelijk van de plaats waar de tumor voorkomt."},"pt":{"name":"Melanoma maligno da mucosa"},"pl":{"name":"Złośliwy czerniak błony śluzowej"},"cs":{"name":"Maligní melanom sliznice"},"uk":{"name":"Злоякісна меланома слизової оболонки","definition":"A rare, aggressive, neoplastic disease characterized by the presence of a melanocyte tumor that develops in any mucosal membrane. Clinical manifestations vary depending on the site of occurrence."},"zh":{"name":"恶性粘膜黑色素瘤","definition":"黏膜恶性黑素细胞瘤一种罕见的侵袭性肿瘤，其特征为任何黏膜上都可出现黑素细胞瘤。临床表现与发生部位有关。"},"tr":{"name":"Mukozanın habis melanomu"}},"xrefs":[{"source":"ICD-10","code":"C43.9","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2E63.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0015694","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C5191057","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":79386,"name":"Rare skin tumor or hamartoma","classifications":[187,202]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult","Elderly"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.26,"area":"Europe","status":"Validated","source":"22119735[PMID]_RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Validated","source":"ORPHANET"},{"type":"Lifetime Prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":1.5,"area":"Europe","status":"Validated","source":"22119735[PMID]_RARECARE surveillance of rare cancers in Europe[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.32,"area":"Belgium","status":"Validated","source":"Belgium Cancer OTHERistry[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.23,"area":"United States","status":"Validated","source":"National Cancer OTHERitute[OTHER]_24272143[PMID]"}],"phenotypes":null}