{"orpha":168966,"name":"Composite lymphoma","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Composite Hodgkin and non-Hodgkin lymphoma"],"definition":"A rare lymphoma characterized by the concurrent occurrence of two or more histologic types of lymphoma involving the same anatomic site. Composite lymphomas can be combinations of two non-Hodgkin lymphomas or of a non-Hodgkin and a Hodgkin lymphoma. In many cases, the tumors are clonally related. Clinical presentation and treatment are determined by the more aggressive component.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-168966/","orphanet_url":"https://www.orpha.net/en/disease/detail/168966","names":{"fr":{"name":"Lymphome composite","synonyms":["Lymphome composite Hodgkinien et non Hodgkinien"],"definition":"Lymphome rare caractérisé par l'apparition simultanée de deux ou plusieurs types histologiques de lymphome au sein du même site anatomique. Les lymphomes composites peuvent être des combinaisons de deux lymphomes non hodgkiniens, ou d'un lymphome non hodgkinien et d'un lymphome hodgkinien. Dans de nombreux cas, les tumeurs sont d'origine clonale. La présentation clinique et le traitement dépendent de la composante la plus agressive."},"de":{"name":"Komposit-Lymphom","synonyms":["Kombinationslymphom von HL und Non-HL"],"definition":"Ein seltenes Lymphom, das durch das gleichzeitige Auftreten von zwei oder mehr histologischen Lymphomtypen an derselben anatomischen Stelle gekennzeichnet ist. Komposit-Lymphome können Kombinationen aus zwei Non-Hodgkin-Lymphomen oder aus einem Non-Hodgkin- und einem Hodgkin-Lymphom sein. In vielen Fällen sind die Tumoren klonal verwandt. Das klinische Bild und die Behandlung werden durch die aggressivere Komponente bestimmt."},"es":{"name":"Linfoma compuesto","synonyms":["Linfoma Hodgkin y no Hodgkin compuesto","Linfoma de Hodgkin y no Hodgkin compuesto"],"definition":"Es un linfoma poco frecuente caracterizado por la aparición simultánea de dos o más tipos histológicos de linfomas afectando al mismo lugar anatómico. Los linfomas compuestos pueden ser combinaciones de dos linfomas no Hodgkin o de un linfoma no Hodgkin y uno Hodgkin. En muchos casos, los tumores están relacionados clonalmente. La presentación clínica y el tratamiento están determinados por el componente más agresivo."},"it":{"name":"Linfoma composito","synonyms":["Linfoma composito di Hodgkin e non-Hodgkin"],"definition":"Si tratta di un linfoma raro, caratterizzato dalla presenza di due o più tipi istologici di linfoma nella stessa sede anatomica. I linfomi compositi possono comprendere l'associazione tra due linfomi non-Hodgkin o tra un linfoma non-Hodgkin e un linfoma Hodgkin. Spesso i tumori sono correlati dal punto di vista clonale. Il quadro clinico e il trattamento dipendono dalla componente più aggressiva."},"nl":{"name":"Samengesteld lymfoom","synonyms":["Samengesteld Hodgkin- en non-Hodgkin-lymfoom"],"definition":"Een zeldzaam lymfoom, gekarakteriseerd door gelijktijdig optreden van twee of meer histologische types van lymfoom in dezelfde anatomische lichaamsstructuur. Gemengd lymfoom kan een combinatie zijn van twee non-Hodgkinlymfomen, of van een non-Hodgkinlymfoom en een Hodgkinlymfoom. In vele gevallen zijn de tumoren klonaal gerelateerd. Klinische presentatie en behandeling worden bepaald door de meer agressieve component."},"pt":{"name":"Linfoma composto"},"pl":{"name":"Chłoniak mieszany","synonyms":["Chłoniak mieszany Hodgkina i non-Hodgkin"]},"cs":{"name":"Kompozitní lymfom","synonyms":["Kompozitní Hodgkinův a non-Hodgkinův lymfom"]},"uk":{"name":"Композитна лімфома","synonyms":["Комбінована лімфома Ходжкіна та неходжкінська лімфома"],"definition":"A rare lymphoma characterized by the concurrent occurrence of two or more histologic types of lymphoma involving the same anatomic site. Composite lymphomas can be combinations of two non-Hodgkin lymphomas or of a non-Hodgkin and a Hodgkin lymphoma. In many cases, the tumors are clonally related. Clinical presentation and treatment are determined by the more aggressive component."},"zh":{"name":"复合淋巴瘤","synonyms":["复合霍奇金和非霍奇金淋巴瘤"]},"tr":{"name":"Kompozit lenfoma","synonyms":["Kompozit Hodgkin ve Hodgkin olmayan lenfoma"]}},"xrefs":[{"source":"ICD-10","code":"C81.7","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C85.7","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"XH3BP6","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"188582256"},{"source":"MONDO","code":"0005710","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D058617","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0545080","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10073957","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":223735,"name":"Lymphoma","classifications":[194,202,233]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult","Elderly"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"<1 / 1 000 000","value":0.01,"area":"Europe","status":"Validated","source":"RARECARE surveillance of rare cancers in Europe[OTHER]"}],"phenotypes":null}