{"orpha":1679,"name":"Diphtheria","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare bacterial infectious disease characterized by an affliction of the upper respiratory tract mediated by the toxin of <i>Corynebacterium diphtheriae</i>. Symptoms include formation of an inflammatory pseudomembrane, fever, sore throat, headaches, coughing, dysphagia, dyspnea, and prominently swollen cervical lymph nodes. The disease may lead to respiratory failure and severe toxin-mediated damage of internal organs, including the heart and kidneys. A cutaneous form of diphtheria is more common in tropical climates and usually follows an indolent course.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-1679/","orphanet_url":"https://www.orpha.net/en/disease/detail/1679","names":{"fr":{"name":"Diphtérie","definition":"Maladie infectieuse bactérienne rare caractérisée par une infection des voies respiratoires supérieures médiée par la toxine produite par <i>Corynebacterium diphtheriae</i>. Les symptômes incluent la formation d'une pseudomembrane inflammatoire, une fièvre, des maux de gorge, des maux de tête, une toux, une dysphagie, une dyspnée et une inflammation importante des ganglions lymphatiques cervicaux. L'infection peut entraîner une insuffisance respiratoire et la toxine diphtérique peut gravement endommager les organes internes. Une forme cutanée, d'évolution généralement indolente, est plus courante dans les zones de climat tropical."},"de":{"name":"Diphterie","definition":"Eine seltene bakterielle Infektionskrankheit, die durch einen Befall der oberen Atemwege gekennzeichnet ist, der durch das Toxin von <i>Corynebacterium diphtheriae</i> verursacht wird. Zu den Symptomen gehören die Bildung einer entzündlichen Pseudomembran, Fieber, Halsschmerzen, Kopfschmerzen, Husten, Schluckstörungen, Dyspnoe und stark geschwollene Halslymphknoten. Die Krankheit kann zu Atemstillstand und schweren toxinvermittelten Schäden an inneren Organen, einschließlich Herz und Nieren, führen. Eine kutane Form der Diphtherie ist in tropischen Klimazonen häufiger anzutreffen und verläuft in der Regel indolent."},"es":{"name":"Difteria","definition":"Es una enfermedad infecciosa bacteriana poco frecuente caracterizada por una aflicción del tracto respiratorio superior mediada por la toxina producida por <i>Corynebacterium diphtheriae</i>. Los síntomas incluyen la formación de una pseudo-membrana inflamatoria, fiebre, dolor de garganta, cefalea, tos, disfagia, disnea y una inflamación importante de los ganglios linfáticos cervicales. La enfermedad puede progresar a insuficiencia respiratoria y a daño grave de los órganos internos mediado por toxinas, incluyendo el corazón y los riñones. En climas tropicales es más frecuente una forma cutánea de la difteria que, por lo general, tiene un curso indolente."},"it":{"name":"Difterite","definition":"Si tratta di un'infezione batterica rara, che interessa le vie aeree superiori ed è mediata dalla tossina del <i>Corynebacterium diphtheriae</i>. I sintomi comprendono la formazione di una pseudomembrana infiammatoria, la febbre, il mal di gola, la cefalea, la tosse, la disfagia, la dispnea e il marcato ingrossamento dei linfonodi cervicali. La malattia può causare una insufficienza respiratoria e un grave danno agli organi interni, compresi il cuore e i reni, mediato dalla tossina. Nei climi tropicali è più comune la forma cutanea della malattia, di solito caratterizzata da un decorso silente."},"nl":{"name":"Difterie","definition":"Een zeldzame, bacteriële infectieuze aandoening, gekarakteriseerd door problemen aan de bovenste luchtwegen gemedieerd door het toxine van <i>Corynebacterium diphtheriae</i>. Symptomen zijn onder meer vorming van een inflammatoir pseudomembraan, koorts, keelpijn, hoofdpijn, hoest, dysfagie, dyspneu, en duidelijk gezwollen cervicale lymfeklieren. De ziekte kan leiden tot respiratoir falen en ernstige toxine-gemedieerde beschadiging van interne organen, waaronder het hart en de nieren. Een cutane vorm van difterie komt vaker voor in tropische klimaten en heeft meestal een indolent verloop."},"pt":{"name":"Difteria"},"pl":{"name":"Błonica"},"cs":{"name":"Záškrt","synonyms":["Diftérie","Mázdřivka"]},"uk":{"name":"Дифтерія","definition":"A rare bacterial infectious disease characterized by an affliction of the upper respiratory tract mediated by the toxin of <i>Corynebacterium diphtheriae</i>. Symptoms include formation of an inflammatory pseudomembrane, fever, sore throat, headaches, coughing, dysphagia, dyspnea, and prominently swollen cervical lymph nodes. The disease may lead to respiratory failure and severe toxin-mediated damage of internal organs, including the heart and kidneys. A cutaneous form of diphtheria is more common in tropical climates and usually follows an indolent course."},"zh":{"name":"白喉"},"tr":{"name":"Difteri"}},"xrefs":[{"source":"ICD-10","code":"A36.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A36.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A36.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A36.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A36.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A36.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C17","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"508032285"},{"source":"ICD-11","code":"1C17.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1347332965"},{"source":"ICD-11","code":"1C17.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"889546481"},{"source":"ICD-11","code":"1C17.2","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1101542926"},{"source":"ICD-11","code":"1C17.3","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"618920860"},{"source":"ICD-11","code":"1C17.Y","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0005504","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D004165","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0012546","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"1875","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10013023","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2011[OTHER]"}],"phenotypes":null}