{"orpha":163525,"name":"Subacute cutaneous lupus erythematosus","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. This disorder is associated with anti-Ro/SSA antibodies and can be drug-induced.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-163525/","orphanet_url":"https://www.orpha.net/en/disease/detail/163525","names":{"fr":{"name":"Lupus érythémateux cutané subaigu","definition":"Forme de lupus érythémateux cutané (LEC) qui peut se manifester par une photodermatose annulaire non cicatricielle ou par de plaques psoriasiformes. La maladie est associée aux anticorps anti-Ro/SSA et peut être induite par des médicaments."},"de":{"name":"Lupus erythematodes, kutaner, subakuter"},"es":{"name":"Lupus eritematoso cutáneo subagudo","definition":"Es una forma de lupus eritematoso cutáneo (CLE) que puede presentarse como una dermatosis anular fotodistribuida o en forma de placas psoriasiformes, sin la formación de cicatrices. Se asocia a anticuerpos anti-Ro/SSA y puede estar inducida por fármacos."},"it":{"name":"Lupus eritematoso cutaneo subacuto","definition":"Il lupus eritematoso cutaneo subacuto (SCLE) è una forma di lupus eritematoso cutaneo (CLE; si veda questo termine) che esordisce sotto forma di fotodermatosi anulare non cicatriziale, oppure di placche psoriasiformi.La malattia si associa agli anticorpi anti-Ro/SSA e può essere indotta dai farmaci."},"nl":{"name":"Subacute cutane lupus erythematosus","definition":"Een vorm van cutane lupus erythematosus (CLE) die zich kan manifesteren als ringvormige dermatose zonder littekenvorming op plaatsen blootgesteld aan licht of als psoriasiforme plaques. Deze aandoening is geassocieerd met anti-Ro/SSA-antilichamen en kan geïnduceerd worden door medicatie."},"pt":{"name":"Lupus eritematoso cutâneo subagudo"},"pl":{"name":"Podostry toczeń rumieniowy skórny"},"cs":{"name":"Subakutní kožní lupus erythematodes"},"uk":{"name":"Підгострий шкірний червоний вовчак","definition":"A form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. This disorder is associated with anti-Ro/SSA antibodies and can be drug-induced."},"zh":{"name":"亚急性皮肤红斑狼疮","definition":"皮肤红斑狼疮(CLE)的一种，可表现为无瘢痕的环状光化性皮肤病或银屑病。该疾病与抗Ro/SSA抗体相关，也可由药物引起。"},"tr":{"name":"Subakut kutanöz lupus eritematozus"}},"xrefs":[{"source":"ICD-10","code":"L93.1","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"EB50","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"192274757"},{"source":"MONDO","code":"0015573","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0024140","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10057903","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":89826,"name":"Rare skin disease"},"parents":[{"orpha":535,"name":"Rare cutaneous lupus erythematosus","classifications":[187]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adult","Elderly"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.63,"area":"United States","status":"Validated","source":"19289752[PMID]"},{"type":"Point prevalence","qualification":"Value and class","class":"1-9 / 100 000","value":1.4805,"area":"United States","status":"Validated","source":"32141953[PMID]_35359921[PMID]_ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2023-04-11","source":"28185656[PMID]_27799135[PMID]_17207162[PMID]_35907579[PMID]_35198470[PMID]","terms":[{"hpo":"HP:0033555","label":"Anti-Ro/SS-A antibody positivity","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0025528","label":"Annular cutaneous lesion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0003493","label":"Antinuclear antibody positivity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000992","label":"Cutaneous photosensitivity","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0025526","label":"Psoriasiform lesion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002923","label":"Rheumatoid factor positive","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0008066","label":"Abnormal blistering of the skin","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032235","label":"Anti-La/SS-B antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0020151","label":"Anti-dsDNA antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0033558","label":"Anti-histone antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003613","label":"Antiphospholipid antibody positivity","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0004334","label":"Dermal atrophy","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007417","label":"Discoid lupus rash","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000962","label":"Hyperkeratosis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031541","label":"Linear C3 deposits along the epidermal basement membrane zone","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031540","label":"Linear IgG deposits along the epidermal basement membrane zone","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100825","label":"Cheilitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0025300","label":"Malar rash","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0200029","label":"Vasculitis in the skin","frequency":"Very rare (<4-1%)","criteria":null}]}}