{"orpha":157820,"name":"Cold-induced sweating syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["CISS"],"definition":"Cold-induced sweating syndrome (CISS) is characterized by profuse sweating (involving the chest, face, arms and trunk) induced by cold ambient temperature.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-157820/","orphanet_url":"https://www.orpha.net/en/disease/detail/157820","names":{"fr":{"name":"Syndrome de la transpiration induite par le froid","synonyms":["CISS"],"definition":"Le syndrome de la transpiration induite par le froid (STIF) se caractérise par une transpiration profuse (touchant la poitrine, le visage, les bras et le tronc) induite par une basse température ambiante."},"de":{"name":"Kälteinduziertes Schwitzen","synonyms":["CISS","Syndrom des kälte-induzierten Schwitzens"],"definition":"Das Syndrom des kälte-induzierten Schwitzens (CISS) ist gekennzeichnet durch in kalter Umgebung auftretendes profuses Schwitzen an Thorax, Gesicht, Armen und Stamm."},"es":{"name":"Síndrome de sudoración inducida por frío","synonyms":["CISS"],"definition":"El síndrome de sudoración inducida por frío (CISS) se caracteriza por sudoración profusa (que afecta a pecho, cara, brazos y tórax) inducida por una temperatura ambiental fría."},"it":{"name":"Sindrome della sudorazione indotta dal freddo","synonyms":["CISS"],"definition":"La sindrome da sudorazione indotta dal freddo (CISS) è caratterizzata da sudorazione profusa (che interessa il torace, la faccia, le braccia e il tronco), indotta dalla temperatura ambientale fredda."},"nl":{"name":"Koudegeïnduceerd zweten-syndroom","synonyms":["CISS"],"definition":"Koudegeïnduceerd zweten-syndroom (CISS) wordt gekenmerkt door overmatig zweten (met betrokkenheid van borstkas, aangezicht, armen en romp) geïnduceerd door koude omgevingstemperatuur."},"pt":{"name":"Síndrome do suor induzido pelo frio","definition":"O síndrome de sudorese induzida pelo frio (CISS) é caracterizado por sudorese profusa (envolvendo o tórax, face, braços e tronco) induzida pela temperatura ambiental fria."},"pl":{"name":"Zespół potliwości indukowany chłodem","synonyms":["CISS"]},"cs":{"name":"Syndrom pocení vyvolaného chladem","synonyms":["CISS"]},"uk":{"name":"Синдром потовиділення, викликаний холодом","synonyms":["CISS"],"definition":"Cold-induced sweating syndrome (CISS) is characterized by profuse sweating (involving the chest, face, arms and trunk) induced by cold ambient temperature."},"zh":{"name":"低温诱导出汗综合征","synonyms":["CISS"],"definition":"冷诱导出汗综合征（CISS）是由寒冷的环境温度引起的大量出汗（累及胸部、面部、手臂和躯干）。"},"tr":{"name":"Soğukla indüklenen terleme sendromu","synonyms":["CISS"]}},"xrefs":[{"source":"OMIM","code":"272430","qualifier":"NTBT","icd_relation":null,"validated":true},{"source":"OMIM","code":"610313","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"G90.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8C21.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1884908195"},{"source":"MONDO","code":"0015526","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":401993,"name":"Cold-induced sweating syndrome-hyperthermia spectrum","classifications":[156,181]}],"children":[],"genes":[{"symbol":"KLHL7","name":"kelch like family member 7","gene_type":"gene with protein product","association":"Disease-causing germline mutation(s) (loss of function) in","status":"Assessed","source":"27392078[PMID]","hgnc":"15646","ensembl":"ENSG00000122550","omim":"611119","loci":["7p15.3"]},{"symbol":"CLCF1","name":"cardiotrophin like cytokine factor 1","gene_type":"gene with protein product","association":"Disease-causing germline mutation(s) in","status":"Assessed","source":"1678282[PMID]_21370513[PMID]_20400119[PMID]","hgnc":"17412","ensembl":"ENSG00000175505","omim":"607672","loci":["11q13.2"]},{"symbol":"CRLF1","name":"cytokine receptor like factor 1","gene_type":"gene with protein product","association":"Disease-causing germline mutation(s) in","status":"Assessed","source":"21370513[PMID]_12509788[PMID]_17436251[PMID]","hgnc":"2364","ensembl":"ENSG00000006016","omim":"604237","loci":["19p12"]}],"genes_via_subtypes":[],"inheritance":["Autosomal recessive"],"onset":["Adult","Childhood"],"prevalence":[{"type":"Cases/families","qualification":"Case(s)","class":null,"value":6.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":null}