{"orpha":1560,"name":"Cysticercosis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"Cysticercosis is a parasitic infectious disease characterized by cyst formation in the target tissue of <i>Taenia solium</i> (tapeworm) parasite larvae ingested via the feces of a human with a tapeworm (human-to-human fecal-oral transmission) leading to variable clinical manifestations in muscle, the brain, spinal cord, and eyes. Infection of muscle tissue is generally asymptomatic. Cyst development in the brain and spinal cord is known as neurocysticercosis (NCC) and may cause seizures and headache. NCC can follow a serious course and may be life-threatening. Severe cases of cysticercosis are treated with albendazole and anti-inflammatory drugs.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-1560/","orphanet_url":"https://www.orpha.net/en/disease/detail/1560","names":{"fr":{"name":"Cysticercose","definition":"Parasitose infectieuse caractérisée par la formation de kystes dans les tissus atteints par les larves du parasite <i>Taenia solium</i> (ténia) ingérées avec les selles d'un être humain infecté par le ténia (transmission interhumaine par voie oro fécale), entraînant des manifestations cliniques variables affectant les muscles, le cerveau, la moelle épinière et les yeux. L'infection des tissus musculaires est généralement asymptomatique. Le développement de kystes dans le cerveau et la moelle épinière est connu sous le nom de neurocysticercose (NCC) et peut provoquer des crises d'épilepsie et des maux de tête, son évolution peut être sévère et mettre en jeu le pronostic vital. Les cas graves de cysticercose sont traités avec de l'albendazole et des médicaments anti-inflammatoires."},"de":{"name":"Zystizerkose"},"es":{"name":"Cisticercosis","definition":"Es una enfermedad infecciosa parasitaria caracterizada por la formación en el tejido diana de quistes de larvas de parásitos de <i>Taenia solium</i> (tenia) ingeridas tras contaminación por heces de una persona infectada por tenia (transmisión fecal-oral de humano a humano) produciendo manifestaciones clínicas variables en músculo, cerebro, médula espinal y ojos. Por lo general, la infección del tejido muscular es asintomática. El desarrollo de quistes en el cerebro y la médula espinal se conoce como neurocisticercosis (NCC) y puede producir convulsiones y cefaleas. La NCC puede seguir un curso grave y ser potencialmente mortal. Los casos graves de cisticercosis se tratan con albendazol y medicamentos antiinflamatorios."},"it":{"name":"Cisticercosi","definition":"La cisticercosi è una parassitosi infettiva caratterizzata dalla formazione di cisti nel tessuto raggiunto dalle larve del parassita <i>Taenia solium</i> (verme solitario), ingerite attraverso le feci di una persona affetta dal verme solitario (trasmissione oro-fecale da uomo a uomo). I segni clinici sono variabili e interessano i muscoli, il cervello, il midollo spinale e gli occhi. L'infezione dei muscoli di solito è asintomatica. Lo sviluppo di cisti nel cervello e nel midollo spinale è noto come neurocisticercosi (NCC); può causare crisi epilettiche e cefalea e può avere un decorso grave e potenzialmente letale. I casi gravi di cisticercosi vengono trattati con albendazolo e con farmaci antinfiammatori."},"nl":{"name":"Cysticercose","definition":"Cysticercose is een parasitaire infectieziekte die gekarakteriseerd wordt door vorming van cysten in het doelweefsel van larven van de parasiet <i>Taenia solium</i> (lintworm), opgenomen via de feces van een mens met een lintworm (fecale-orale transmissie van mens op mens), wat leidt tot variabele klinische manifestaties in spieren, de hersenen, het ruggenmerg, en de ogen. Infectie van spierweefsel is doorgaans asymptomatisch. Ontwikkeling van cysten in de hersenen en het ruggenmerg staat bekend als neurocysticercose (NCC) en kan insulten en hoofdpijn veroorzaken. NCC kan een ernstig verloop vertonen en is mogelijk levensbedreigend. Ernstige gevallen van cysticercose worden behandeld met albendazol en anti-inflammatoire geneesmiddelen."},"pt":{"name":"Cisticercose"},"pl":{"name":"Wągrzyca"},"cs":{"name":"Cysticerkóza"},"uk":{"name":"Цистицеркоз","definition":"Cysticercosis is a parasitic infectious disease characterized by cyst formation in the target tissue of <i>Taenia solium</i> (tapeworm) parasite larvae ingested via the feces of a human with a tapeworm (human-to-human fecal-oral transmission) leading to variable clinical manifestations in muscle, the brain, spinal cord, and eyes. Infection of muscle tissue is generally asymptomatic. Cyst development in the brain and spinal cord is known as neurocysticercosis (NCC) and may cause seizures and headache. NCC can follow a serious course and may be life-threatening. Severe cases of cysticercosis are treated with albendazole and anti-inflammatory drugs."},"zh":{"name":"囊虫病"},"tr":{"name":"Sistiserkoz"}},"xrefs":[{"source":"ICD-10","code":"B69.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B69.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B69.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B69.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F70","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1324863907"},{"source":"ICD-11","code":"1F70.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"487162814"},{"source":"ICD-11","code":"1F70.00","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"501370275"},{"source":"ICD-11","code":"1F70.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"2017611304"},{"source":"ICD-11","code":"1F70.Y","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0015484","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D003551","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0010678","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"8194","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10011775","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163588,"name":"Rare parasitic disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2020-11-25","source":"7846114[PMID]_28449318[PMID]_7846114[PMID]","terms":[{"hpo":"HP:0000707","label":"Abnormality of the nervous system","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010651","label":"Abnormal meningeal morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0011805","label":"Abnormal skeletal muscle morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012703","label":"Abnormal subarachnoid space morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012443","label":"Abnormality of brain morphology","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100702","label":"Arachnoid cyst","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0200149","label":"CSF lymphocytic pleiocytosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002514","label":"Cerebral calcification","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0004302","label":"Functional motor deficit","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002922","label":"Increased CSF protein concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0410234","label":"Increased anti-parasite IgE antibody level","frequency":"Frequent (79-30%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0010702","label":"Increased circulating immunoglobulin concentration","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0010576","label":"Intracranial cystic lesion","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Frequent (79-30%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0003474","label":"Somatic sensory dysfunction","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012372","label":"Abnormal eye morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001637","label":"Abnormal myocardium morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000929","label":"Abnormal skull morphology","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000925","label":"Abnormality of the vertebral column","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000708","label":"Atypical behavior","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100249","label":"Calcification of muscles","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006824","label":"Cranial nerve paralysis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000651","label":"Diplopia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000712","label":"Emotional lability","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007359","label":"Focal-onset seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002197","label":"Generalized-onset seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000738","label":"Hallucinations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002516","label":"Increased intracranial pressure","frequency":"Occasional (29-5%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0002354","label":"Memory impairment","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000933","label":"Posterior fossa cyst at the fourth ventricle","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100561","label":"Spinal cord lesion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0009745","label":"Spinalarachnoid cyst","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002133","label":"Status epilepticus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025258","label":"Stiff neck","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002493","label":"Upper motor neuron dysfunction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025163","label":"Abnormality of optic chiasm morphology","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000741","label":"Apathy","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0004420","label":"Arterial thrombosis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001251","label":"Ataxia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0012424","label":"Chorioretinitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001289","label":"Confusion","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0000726","label":"Dementia","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001260","label":"Dysarthria","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0002383","label":"Infectious encephalitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001094","label":"Iridocyclitis","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0007185","label":"Loss of consciousness","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001268","label":"Mental deterioration","frequency":"Very rare (<4-1%)","criteria":"Diagnostic criterion"},{"hpo":"HP:0000541","label":"Retinal detachment","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0001297","label":"Stroke","frequency":"Very rare (<4-1%)","criteria":null}]}}