{"orpha":150,"name":"Nasopharyngeal carcinoma","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["NCP","Squamous cell carcinoma of the nasopharynx"],"definition":"Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-150/","orphanet_url":"https://www.orpha.net/en/disease/detail/150","names":{"fr":{"name":"Carcinome nasopharyngé","synonyms":["Carcinome épidermoïde du nasopharynx"],"definition":"Le carcinome nasopharyngé (NPC) est une tumeur provenant des cellules épithéliales qui tapissent le nasopharynx."},"de":{"name":"Nasopharynxkarzinom","synonyms":["NCP","Plattenepithelkarzinom des Nasopharynx"],"definition":"Das Nasopharynxkarzinom (NPC) ist ein Tumor, der von den Epithelzellen ausgeht, die den Nasenrachenraum auskleiden."},"es":{"name":"Carcinoma nasofaríngeo","synonyms":["Carcinoma de células escamosas de la nasofaringe"],"definition":"El carcinoma nasofaríngeo (CNF) es un tumor que se origina en las células epiteliales que cubren la superficie y revisten la nasofaringe."},"it":{"name":"Carcinoma nasofaringeo","synonyms":["Carcinoma a cellule squamose del nasofaringe","NCP"]},"nl":{"name":"Carcinoom van nasofarynx","synonyms":["NCP","Nasofaryngeaal carcinoom","Plaveiselcelcarcinoom van nasofarynx"],"definition":"Een tumor die ontstaat uit epitheelcellen die het oppervlakte van nasofarynx bekleden."},"pt":{"name":"Carcinoma nasofaringeo","synonyms":["Carcinoma de células escamosas da nasofaringe","NCP"]},"pl":{"name":"Rak jamy nosowo-gardłowej","synonyms":["NCP","Squamous cell carcinoma of the nasopharynx"]},"cs":{"name":"Nasofaryngeální karcinom","synonyms":["NCP","Squamous cell carcinoma of the nasopharynx"]},"uk":{"name":"Карцинома носоглотки","synonyms":["Плоскоклітинний рак носоглотки"],"definition":"Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx."},"zh":{"name":"鼻咽癌","synonyms":["鼻咽鳞状细胞癌"]},"tr":{"name":"Nazofarenks karsinomu","synonyms":["Nazofarenksin skuamöz hücreli karsinomu"]}},"xrefs":[{"source":"OMIM","code":"161550","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"OMIM","code":"607107","qualifier":"E","icd_relation":null,"validated":true},{"source":"OMIM","code":"617075","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"C11.0","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C11.1","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C11.2","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-10","code":"C11.3","qualifier":"BTNT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"2E60.0","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"1626158287"},{"source":"MONDO","code":"0015459","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D000077274","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2931822","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"7163","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10028793","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":250908,"name":"Rare neoplastic disease"},"parents":[{"orpha":289651,"name":"Epstein-Barr Virus-associated carcinoma","classifications":[202]},{"orpha":98061,"name":"Rare otorhinolaryngologic tumor","classifications":[200,202]},{"orpha":98060,"name":"Rare respiratory tumor","classifications":[184,202]}],"children":[],"genes":[{"symbol":"NFKBIA","name":"NFKB inhibitor alpha","gene_type":"gene with protein product","association":"Disease-causing somatic mutation(s) in","status":"Assessed","source":"27647909[PMID]","hgnc":"7797","ensembl":"ENSG00000100906","omim":"164008","loci":["14q13.2"]}],"genes_via_subtypes":[],"inheritance":["Multigenic/multifactorial","Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.2,"area":"China","status":"Validated","source":"8061578[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet 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