{"orpha":1489,"name":"Whooping cough","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Pertussis"],"definition":"A rare bacterial infectious disease characterized by severe coughing paroxysms with inspiratory whooping and posttussive vomiting, caused by infection with <i>Bordetella pertussis</i>. After a variable incubation time, the clinical course progresses through a catarrhal stage with sore throat, nasal congestion, rhinorrhea, and mild progressive dry cough, a paroxysmal stage with the typical paroxysmal coughing, and finally convalescence. Disease duration is usually 2-3 months, often with milder presentation in adolescents and adults than in infants and children.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-1489/","orphanet_url":"https://www.orpha.net/en/disease/detail/1489","names":{"fr":{"name":"Coqueluche","synonyms":["Pertussis"],"definition":"Maladie infectieuse bactérienne rare caractérisée par des paroxysmes de toux sévères avec une coqueluche et vomissements post-tussifs, causée par une infection par <i>Bordetella pertussis</i>. Après un temps d'incubation variable, l'évolution clinique passe par une phase catarrhale avec des maux de gorge, une congestion nasale, une rhinorrhée et une toux sèche progressive légère, une phase paroxystique avec une toux paroxystique typique, et enfin la convalescence. La maladie dure généralement de deux à trois mois, les signes étant souvent plus sévères chez les nourrissons et les enfants que chez les adolescents et les adultes."},"de":{"name":"Keuchhusten","synonyms":["Pertussis"],"definition":"Eine seltene bakterielle Infektionskrankheit, die durch schwere Hustenparoxysmen mit inspiratorischem Keuchhusten und posttussivem Erbrechen gekennzeichnet ist und durch eine Infektion mit <i>Bordetella pertussis</i> verursacht wird. Nach einer variablen Inkubationszeit verläuft der klinische Verlauf über ein katarrhalisches Stadium mit Halsschmerzen, nasaler Kongestion, Rhinorrhoe und mildem, progressivem trockenem Husten, ein paroxysmales Stadium mit dem typischen paroxysmalen Husten und schließlich die Rekonvaleszenz. Die Krankheitsdauer beträgt in der Regel 2-3 Monate, wobei der Verlauf bei Jugendlichen und Erwachsenen oft milder ist als bei Säuglingen und Kindern."},"es":{"name":"Tos ferina","synonyms":["Tosferina"],"definition":"Es una enfermedad infecciosa bacteriana poco frecuente caracterizada por tos paroxística intensa con estridor inspiratorio y vómitos postusivos, causados por una infección por <i>Bordetella pertussis</i>. Después de un tiempo de incubación variable, el curso clínico evoluciona a una etapa catarral con dolor de garganta, congestión nasal, rinorrea y leve tos seca progresiva, una etapa paroxística con la tos paroxística típica y finalmente a la etapa de convalecencia. La enfermedad suele durar de 2 a 3 meses, habitualmente con una presentación más leve en adolescentes y adultos que en lactantes y niños."},"it":{"name":"Tosse canina","synonyms":["Pertosse"],"definition":"Si tratta di un'infezione batterica rara, caratterizzata da gravi parossismi di tosse associati a forte stridore inspiratorio e vomito scatenato dall'accesso di tosse; la malattia è causata da una infezione da <i>Bordetella pertussis</i>. Dopo un'incubazione di durata variabile, la malattia esordisce con una fase catarrale, caratterizzata da mal di gola, congestione nasale, rinorrea e tosse secca lieve e progressiva, per progredire verso lo stadio parossistico caratterizzato dalla tipica tosse parossistica e, infine, verso la convalescenza. La malattia dura circa 2-3 mesi; in genere il quadro clinico è più lieve negli adolescenti e negli adulti rispetto ai neonati e ai bambini."},"nl":{"name":"Kinkhoest","synonyms":["Pertussis"],"definition":"Een zeldzame, bacteriële infectieuze aandoening, gekarakteriseerd door ernstige hoestaanvallen met luid inademen en braken na de hoestbui, veroorzaakt door infectie met <i>Bordetella pertussis</i>. Na een variabele incubatietijd gaat het klinisch verloop door een catarrale fase met pijnlijke keel, neuscongestie, rinorroe, en mild progressieve droge hoest, een paroxysmale fase met de typische paroxysmale hoest, en tenslotte convalescentie. De ziekte duurt doorgaans 2-3 maanden, vaak met een mildere presentatie bij adolescenten en volwassenen dan bij zuigelingen en kinderen."},"pt":{"name":"Tosse convulsa","synonyms":["Pertussis"]},"pl":{"name":"Krztusiec","synonyms":["Pertussis"]},"cs":{"name":"Černý kašel","synonyms":["Pertusse","Dávivý kašel"]},"uk":{"name":"Кашлюк","synonyms":["Кашлюк"],"definition":"A rare bacterial infectious disease characterized by severe coughing paroxysms with inspiratory whooping and posttussive vomiting, caused by infection with <i>Bordetella pertussis</i>. After a variable incubation time, the clinical course progresses through a catarrhal stage with sore throat, nasal congestion, rhinorrhea, and mild progressive dry cough, a paroxysmal stage with the typical paroxysmal coughing, and finally convalescence. Disease duration is usually 2-3 months, often with milder presentation in adolescents and adults than in infants and children."},"zh":{"name":"百日咳","synonyms":["百日咳"]},"tr":{"name":"Boğmaca","synonyms":["Boğmaca"]}},"xrefs":[{"source":"ICD-10","code":"A37.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A37.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A37.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"A37.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1C12.0","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1287021540"},{"source":"MONDO","code":"0005077","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D014917","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0043167","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"8692","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10047974","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["All ages"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":8.9,"area":"Europe","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.22,"area":"Lithuania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.14,"area":"Luxembourg","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.52,"area":"Malta","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":31.72,"area":"Netherlands","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":47.24,"area":"Norway","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":10.6,"area":"Poland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.1,"area":"Portugal","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.42,"area":"Romania","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":10.5,"area":"Slovakia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":9.5,"area":"Slovenia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":8.3,"area":"Spain","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":6.2,"area":"Sweden","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":8.5,"area":"United Kingdom","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":9.76,"area":"Austria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":10.08,"area":"Belgium","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.08,"area":"Bulgaria","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.88,"area":"Cyprus","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":10.7,"area":"Czech Republic","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":19.16,"area":"Denmark","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":4.66,"area":"Estonia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":5.1,"area":"Finland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":15.4,"area":"Germany","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.38,"area":"Greece","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.16,"area":"Hungary","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":2.34,"area":"Croatia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":5.3,"area":"Iceland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":3.58,"area":"Ireland","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.2,"area":"Italy","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":8.48,"area":"Latvia","status":"Validated","source":"European Centre for Disease prevention and Control 2013-2017[OTHER]"}],"phenotypes":null}