{"orpha":140286,"name":"Secondary hypoparathyroidism due to impaired parathormon secretion","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-140286/","orphanet_url":"https://www.orpha.net/en/disease/detail/140286","names":{"fr":{"name":"Hypoparathyroïdie secondaire due à un défaut de sécrétion de parathormone"},"de":{"name":"Hypoparathyreoidismus durch gestörte Parathormon-Sekretion, sekundärer"},"es":{"name":"Hipoparatiroidismo secundario por una secreción deficiente de paratohormona"},"it":{"name":"Ipoparatiroidismo secondario da deficit di secrezione del paratormone"},"nl":{"name":"Secundaire hypoparathyreoïdie door verminderde parathormoonsecretie"},"pt":{"name":"Hipoparatiroidismo por secreção reduzida da paratormona, secundária"},"pl":{"name":"Wtórna niedoczynność przytarczyc z powodu upośledzonego wydzielania parathormonu"},"cs":{"name":"Sekundární hypoparatyreóza způsobená poruchou sekrece parathormonu"},"uk":{"name":"Вторинний гіпопаратиреоз внаслідок порушення секреції паратгормону"},"zh":{"name":"甲状旁腺激素分泌受损所致继发性甲状旁腺功能减退"},"tr":{"name":"Bozulmuş parathormon sekresyonuna bağlı sekonder hipoparatiroidi"}},"xrefs":[{"source":"ICD-10","code":"E20.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"5A50.01","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1229357339"},{"source":"MONDO","code":"0015357","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C4305428","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"19922","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":97978,"name":"Rare endocrine disease"},"parents":[{"orpha":181405,"name":"Rare hypoparathyroidism","classifications":[193]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":24.75,"area":"Europe","status":"Validated","source":"29087618[PMID]_23661265[PMID]_29516129[PMID]_30375660[PMID]"},{"type":"Annual incidence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Europe","status":"Validated","source":"ORPHANET"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 1 000 000","value":0.8,"area":"Denmark","status":"Validated","source":"23661265[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-9 / 100 000","value":1.7,"area":"Spain","status":"Validated","source":"32155210[PMID]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-07-01","source":"28722928[PMID]_22863393[PMID]_26943720[PMID]","terms":[{"hpo":"HP:0000828","label":"Abnormality of the parathyroid gland","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002135","label":"Basal ganglia calcification","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031817","label":"Decreased circulating parathyroid hormone level","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002905","label":"Hyperphosphatemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002901","label":"Hypocalcemia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000829","label":"Hypoparathyroidism","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000121","label":"Nephrocalcinosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0031006","label":"Acroparesthesia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000739","label":"Anxiety","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0011675","label":"Arrhythmia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007302","label":"Bipolar affective disorder","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0033630","label":"Brain fog","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:4000007","label":"Bronchoconstriction","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0031990","label":"Chvostek sign","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000716","label":"Depression","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002380","label":"Fasciculations","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002150","label":"Hypercalciuria","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0033748","label":"Hypoesthesia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0025425","label":"Laryngospasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0003394","label":"Muscle spasm","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002749","label":"Osteomalacia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0007787","label":"Posterior subcapsular cataract","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002748","label":"Rickets","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001250","label":"Seizure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:6000919","label":"Trousseau sign","frequency":"Occasional (29-5%)","criteria":null}]}}