{"orpha":137839,"name":"Lemierre syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Lemierre postanginal sepsis","Postanginal sepsis secondary to orophyngeal infection","Septic phlebitis of the internal jugular vein"],"definition":"Lemierre syndrome is a rare, potentially lethal, oropharyngeal infectious disease occurring in immunocompetent adolescents and young adults that is mainly due to <i>Fusobacterium necrophorum</i> and that is characterized by septic thrombophlebitis of the internal jugular vein that leads to septic, usually pulmonary, embolism, associated with ENT (ear, nose, and throat) infection that manifests with fever, neck pain, and tonsillopharyngitis.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-137839/","orphanet_url":"https://www.orpha.net/en/disease/detail/137839","names":{"fr":{"name":"Syndrome de Lemierre","synonyms":["Sepsis post-angine de Lemierre","Sepsis post-angine secondaire à une infection oropharyngée","Thrombophlébite septique de la veine jugulaire interne"],"definition":"Maladie infectieuse oropharyngée rare, potentiellement mortelle, survenant chez l'adolescent et le jeune adulte immunocompétents, principalement due à <i>Fusobacterium necrophorum</i> et caractérisée par une thrombophlébite septique de la veine jugulaire interne conduisant à une embolie septique, généralement pulmonaire, associée à une infection ORL se manifestant par de la fièvre, des douleurs cervicales et une pharyngoamygdalite."},"de":{"name":"Lemierre-Syndrom","synonyms":["Postangina-Sepsis Lemierre","Postanginale Sepsis nach oropharyngealer Infektion","Septische Phlebitis der internen Jugularvene"]},"es":{"name":"Síndrome de Lemierre","synonyms":["Flebitis séptica de la vena yugular interna","Sepsis postangina secundaria a infección orofaríngea","Sepsis postanginal de Lemierre","Sepsis postanginal secundaria a una infección orofaríngea"],"definition":"Es una enfermedad infecciosa orofaríngea poco frecuente y potencialmente letal que se presenta en adolescentes y adultos jóvenes inmunocompetentes y que se debe principalmente a&#160;<i>Fusobacterium necrophorum</i>. Está caracterizada por una tromboflebitis séptica de la vena yugular interna que conduce a una embolia séptica, generalmente pulmonar, asociada a infección ORL (oído, nariz y garganta) que se manifiesta con fiebre, dolor de cuello y faringoamigdalitis."},"it":{"name":"Sindrome di Lemierre","synonyms":["Flebite settica della vena giugulare interna","Sepsi post-angina di Lemierre","Sepsi post-angina secondaria a infezioni orofaringee"]},"nl":{"name":"Lemierresyndroom","synonyms":["Postanginale sepsis secundair aan orofaryngeale infectie","Postanginale sepsis van Lemierre","Septische flebitis van de inwendige halsader"],"definition":"Lemierresyndroom is een zeldzame, potentieel letale, orofaryngeale infectieziekte die voorkomt bij immuuncompetente adolescenten en jonge volwassenen en die voornamelijk te wijten is aan <i>Fusobacterium necrophorum<i>. De ziekte wordt gekenmerkt door septische tromboflebitis van de vena jugularis interna, die leidt tot septische, gewoonlijk pulmonale embolie, geassocieerd met ENT (oor, neus en keel)-infectie die zich manifesteert met koorts, nekpijn en tonsillofaryngitis."},"pt":{"name":"Síndrome de Lemierre"},"pl":{"name":"Zespół Lemierre'a","synonyms":["Poanginowa posocznica Lemierre'a","Septyczne zapalenie żyły szyjnej wewnętrznej","Wtórna posocznica poanginowa po infekcji gardła"]},"cs":{"name":"Lemierrův syndrom","synonyms":["Lemierrova postanginózní sepse","Sekundární postanginózní sepse po orofaryngeální infekci","Septická flebitida vnitřní krční žíly"]},"uk":{"name":"Синдром Лемєра","synonyms":["Постангінальний сепсис Лемєра","Постангінальний сепсис, спричинений інфекцією ротоглотки","Септичний флебіт внутрішньої яремної вени"],"definition":"Lemierre syndrome is a rare, potentially lethal, oropharyngeal infectious disease occurring in immunocompetent adolescents and young adults that is mainly due to <i>Fusobacterium necrophorum</i> and that is characterized by septic thrombophlebitis of the internal jugular vein that leads to septic, usually pulmonary, embolism, associated with ENT (ear, nose, and throat) infection that manifests with fever, neck pain, and tonsillopharyngitis."},"zh":{"name":"Lemierre综合征","synonyms":["口咽部感染所致咽峡后脓毒血症"],"definition":"Lemierre综合征是一种罕见的、潜在致命的口咽传染病，发生于免疫功能正常的青少年和青年人，主要由 坏死梭杆菌引起，其特征是可导致败血病的颈内静脉脓毒性血栓性静脉炎，通常为肺栓塞，且与ENT（耳、鼻、喉）感染相关，表现为发热、颈痛和扁桃体炎。"},"tr":{"name":"Lemierre sendromu","synonyms":["Lemierre postanginal sepsis","İç juguler venin septik flebiti","Orofingeal enfeksiyona sekonder postanginal sepsis"]}},"xrefs":[{"source":"ICD-10","code":"I80.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1C4Y","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"MONDO","code":"0015306","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D057831","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0343525","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"6882","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10065552","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163582,"name":"Rare bacterial infectious disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":["Adolescent"],"prevalence":[{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":10.0,"area":"Europe","status":"Not yet validated","source":"20181152[PMID]"},{"type":"Annual incidence","qualification":"Value and class","class":"1-5 / 10 000","value":36.0,"area":"Denmark","status":"Validated","source":"22633566[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}