{"orpha":137817,"name":"Arachnoiditis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Adhesive arachnoiditis","Chronic arachnoiditis"],"definition":"A chronic inflammation of the arachnoid layer of the meninges, of which adhesive arachnoiditis is the most severe form, characterized by debilitating, intractable neurogenic back and limb pain and a range of other neurological problems.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-137817/","orphanet_url":"https://www.orpha.net/en/disease/detail/137817","names":{"fr":{"name":"Arachnoïdite","synonyms":["Arachnoïdite adhésive","Arachnoïdite chronique"],"definition":"L'arachnoïdite est une inflammation chronique du feuillet arachnoïdien des méninges, dont la forme la plus sévère est l'arachnoïdite adhésive, caractérisée par une douleur neurogène, invalidante et réfractaire du dos et des membres et par un ensemble d'autres troubles neurologiques."},"de":{"name":"Arachnoiditis","synonyms":["Arachnoiditis, adhäsive","Arachnoiditis, chronische"],"definition":"Die Arachnoiditis (ARC) ist eine chronische Entzündung der auf den Meningen liegenden Arachnoidea. Die schwerste Form, die adhäsive Arachnoiditis, ist gekennzeichnet durch schwer beeinträchtigende, therapieresistente Rücken- und Gliederschmerzen und eine Reihe anderer neurologischer Probleme."},"es":{"name":"Aracnoiditis","synonyms":["Aracnoiditis adhesiva","Aracnoiditis crónica"],"definition":"Es una inflamación crónica de la capa aracnoides de las meninges, de la cual la aracnoiditis adhesiva es la forma más grave, caracterizada por dolor neurogénico debilitante e intratable de la espalda y las extremidades y una variedad de problemas neurológicos adicionales."},"it":{"name":"Aracnoidite","synonyms":["Aracnoidite adesiva","Aracnoidite cronica"]},"nl":{"name":"Arachnoïditis","synonyms":["Adhesieve arachnoïditis","Chronische arachnoïditis"],"definition":"Een chronische inflammatie van spinnenwebvlies (arachnoidea), waarvan adhesieve arachnoïditis de meest ernstige vorm is, gekenmerkt door invaliderende, therapieresistente neurogene pijn aan rug en ledematen en een waaier aan andere neurologische problemen."},"pt":{"name":"Aracnoidite adesiva"},"pl":{"name":"Zapalenie pajęczynówki","synonyms":["Przewlekłe zapalenie pajęczynówki","Zlepne zapalenie pajęczynówki"]},"cs":{"name":"Arachnoiditida","synonyms":["Adhezivní arachnoiditida","Chronická arachnoiditida"]},"uk":{"name":"Арахноїдит","synonyms":["Адгезивний арахноїдит","Хронічний арахноїдит"],"definition":"A chronic inflammation of the arachnoid layer of the meninges, of which adhesive arachnoiditis is the most severe form, characterized by debilitating, intractable neurogenic back and limb pain and a range of other neurological problems."},"zh":{"name":"蛛网膜炎","synonyms":["粘连性蛛网膜炎"],"definition":"一种脑膜蛛网膜层的慢性炎症，其中粘连性蛛网膜炎最为严重，其特征是虚弱、顽固性神经源性背部和四肢疼痛和一系列其他神经系统问题。"},"tr":{"name":"Araknoidit","synonyms":["Kronik araknoidit","Adezyon araknoidit"]}},"xrefs":[{"source":"OMIM","code":"182950","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"G03.9","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"8E40.3","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"414817254"},{"source":"MONDO","code":"0015304","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D001100","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0003708","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5839","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10003074","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":98006,"name":"Rare neurologic disease"},"parents":[{"orpha":98006,"name":"Rare neurologic disease","classifications":[181]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"Unknown","value":0.0,"area":"Worldwide","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0000478","label":"Abnormality of the eye","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000504","label":"Abnormality of vision","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002829","label":"Arthralgia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000365","label":"Hearing impairment","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001265","label":"Hyporeflexia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001287","label":"Meningitis","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0001324","label":"Muscle weakness","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0003401","label":"Paresthesia","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000763","label":"Sensory neuropathy","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000360","label":"Tinnitus","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000970","label":"Anhidrosis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000238","label":"Hydrocephalus","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002076","label":"Migraine","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002839","label":"Urinary bladder sphincter dysfunction","frequency":"Occasional (29-5%)","criteria":null}]}}