{"orpha":137698,"name":"Cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk","type":"Particular clinical situation in a disease or syndrome","group":"Disorder","status":"active","flags":[],"synonyms":["CMV disease in patients with impaired cell mediated immunity deemed at risk"],"definition":null,"note":null,"url":"https://raremap.alftech.space/d/ORPHA-137698/","orphanet_url":"https://www.orpha.net/en/disease/detail/137698","names":{"fr":{"name":"Infection à cytomégalovirus chez des patients à risque avec une immunodépression cellulaire","synonyms":["Infection à CMV chez des patients à risque avec une immunodépression cellulaire"]},"de":{"name":"Zytomegalievirus-Infektion bei Risiko-Patienten mit eingeschränkter Zell-vermittelter Immunität"},"es":{"name":"Enfermedad por citomegalovirus (CMV) en pacientes de riesgo por inmunidad celular alterada"},"it":{"name":"Malattia da citomegalovirus in pazienti a rischio per immunodepressione cellulare","synonyms":["Malattia da CMV in pazienti a rischio per immunodepressione cellulare"]},"nl":{"name":"Cytomegalovirusziekte met risico voor patiënten met verminderde celgemedieerde immuniteit","synonyms":["CMV-ziekte met risico voor patiënten met verminderde celgemedieerde immuniteit"]},"pt":{"name":"Infeção por citomegalovirus (CMV) em doentes de risco com imunidade celular diminuída"},"pl":{"name":"Choroba cytomegalowirusowa u pacjentów zagrożonych upośledzeniem odporności komórkowej","synonyms":["Choroba CMV u pacjentów zagrożonych upośledzniem odporności komórkowej"]},"cs":{"name":"Cytomegalovirová infekce u pacientů s poruchou buněčné imunity považovaných za rizikové","synonyms":["CMV infekce u pacientů s poruchou buňkami zprostředkované imunity považovaných za rizikové"]},"uk":{"name":"Цитомегаловірусна хвороба у пацієнтів з ослабленим клітинним імунітетом, які належать до групи ризику","synonyms":["Захворювання на ЦМВ у пацієнтів з ослабленим клітинним імунітетом, які належать до групи ризику"]},"zh":{"name":"伴细胞介导免疫功能受损风险患者的巨细胞病毒病","synonyms":["细胞免疫受损患者中的巨细胞病毒病"]},"tr":{"name":"Hücre aracılı bağışıklığı bozulmuş hastalarda riskli kabul edilen sitomegalovirüs hastalığı","synonyms":["Riskli kabul edilen, hücre aracılı bağışıklığı bozulmuş hastalarda CMV hastalığı"]}},"xrefs":[{"source":"ICD-10","code":"B25.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"1D82.Y","qualifier":"NTBT","icd_relation":"attributed","validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163585,"name":"Rare viral disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":25.5,"area":"Europe","status":"Validated","source":"European Medicines Agency 2012[OTHER]_ORPHANET"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2024-11-27","source":"29083720[PMID]_20481654[PMID]_29596116[PMID]","terms":[{"hpo":"HP:0002027","label":"Abdominal pain","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0002014","label":"Diarrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0012378","label":"Fatigue","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001882","label":"Leukopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0033834","label":"Malaise","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:6001005","label":"Positive gastric CMV intranuclear inclusions","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0001873","label":"Thrombocytopenia","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0006562","label":"Viral hepatitis","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0033431","label":"Cytomegalovirus colitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0001399","label":"Hepatic failure","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0006515","label":"Interstitial pneumonitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0012486","label":"Myelitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0033993","label":"Viral encephalitis","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0032118","label":"Retinitis","frequency":"Very rare (<4-1%)","criteria":null}]}}