{"orpha":137686,"name":"Asherman syndrome","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare, acquired uterine disease characterized by intrauterine adhesions associated with a history of curettage or intrauterine surgery and gynecological symptoms (secondary amenorrhea, hypomenorrhea, pelvic pain, infertility or pregnancy loss).","note":null,"url":"https://raremap.alftech.space/d/ORPHA-137686/","orphanet_url":"https://www.orpha.net/en/disease/detail/137686","names":{"fr":{"name":"Syndrome d'Asherman","definition":"Maladie utérine acquise rare caractérisée par des adhérences intra-utérines associées à des antécédents de curetage ou de chirurgie intra-utérine et à des symptômes gynécologiques (aménorrhée secondaire, hypoménorrhée, douleurs pelviennes, infertilité ou fausse couche)."},"de":{"name":"Asherman-Syndrom","definition":"Eine seltene, erworbene Gebärmuttererkrankung, die durch intrauterine Adhäsionen gekennzeichnet ist und mit einer Vorgeschichte von Kürettage oder intrauterinen Operationen und gynäkologischen Symptomen (sekundäre Amenorrhoe, Hypomenorrhoe, Beckenschmerzen, Unfruchtbarkeit oder Schwangerschaftsverlust) einhergeht."},"es":{"name":"Síndrome de Asherman","definition":"Es una enfermedad uterina adquirida poco frecuente, caracterizada por adherencias intrauterinas asociadas a antecedentes de legrado o de una cirugía intrauterina y síntomas ginecológicos (amenorrea secundaria, hipomenorrea, dolor pélvico, infertilidad o aborto espontáneo)."},"it":{"name":"Sindrome di Asherman","synonyms":["Adesioni intrauterine","Sinechie intrauterine"],"definition":"La sindrome di Asherman è una malattia rara acquisita dell'utero, caratterizzata da aderenze intrauterine secondarie a raschiamenti o a interventi chirurgici intrauterini, che si associa a sintomatologia ginecologica (amenorrea secondaria, ipomenorrea, dolore pelvico, infertilità o aborto spontaneo)."},"nl":{"name":"Syndroom van Asherman","synonyms":["Intra-uteriene adhesies","Intra-uteriene synechiae"],"definition":"Een zeldzame verworven aandoening van uterus, gekarakteriseerd door intra-uteriene adhesies geassocieerd met een voorgeschiedenis van curettage of intra-uteriene chirurgie en gynaecologische symptomen (secundaire amenorroe, hypomenorroe, pijn in bekken, infertiliteit of miskraam)."},"pt":{"name":"Síndrome de Asherman"},"pl":{"name":"Zespół Ashermana","synonyms":["Zrosty wewnątrzmaciczne"]},"cs":{"name":"Ashermanův syndrom","synonyms":["Intrauterinní adheze","Děložní synechie"]},"uk":{"name":"Синдром Ашермана","definition":"A rare, acquired uterine disease characterized by intrauterine adhesions associated with a history of curettage or intrauterine surgery and gynecological symptoms (secondary amenorrhea, hypomenorrhea, pelvic pain, infertility or pregnancy loss)."},"zh":{"name":"Asherman 综合征","definition":"一种罕见的获得性子宫疾病，其特征是子宫内粘连，与刮宫或宫内手术史和妇科症状（继发性闭经、月经过少、骨盆痛、不孕或流产）相关。"},"tr":{"name":"Asherman sendromu"}},"xrefs":[{"source":"ICD-10","code":"N85.6","qualifier":"E","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"GA16.2","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"2022431339"},{"source":"MONDO","code":"0015299","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0156372","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"5853","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10053868","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":96344,"name":"Rare gynecologic or obstetric disease"},"parents":[{"orpha":180205,"name":"Rare non-malformative uterovaginal or vulvovaginal disease","classifications":[205]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adult"],"prevalence":[{"type":"Point prevalence","qualification":"Value and class","class":"1-5 / 10 000","value":44.0,"area":"Europe","status":"Validated","source":"European Medicines Agency 2017[OTHER]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2019-06-25","source":"28846336[PMID]_29493709[PMID]_30713131[PMID]_30936754[PMID]","terms":[{"hpo":"HP:0000140","label":"Abnormality of the menstrual cycle","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000868","label":"Decreased fertility in females","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0000876","label":"Oligomenorrhea","frequency":"Frequent (79-30%)","criteria":null},{"hpo":"HP:0100607","label":"Dysmenorrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0002574","label":"Episodic abdominal pain","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000789","label":"Infertility","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100608","label":"Metrorrhagia","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0000869","label":"Secondary amenorrhea","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0005268","label":"Spontaneous abortion","frequency":"Occasional (29-5%)","criteria":null},{"hpo":"HP:0100767","label":"Abnormality of the placenta","frequency":"Very rare (<4-1%)","criteria":null},{"hpo":"HP:0031035","label":"Chronic infection","frequency":"Very rare (<4-1%)","criteria":null}]}}