{"orpha":1247,"name":"Schistosomiasis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Bilharziasis"],"definition":"A rare parasitic disease characterized by infection with trematodes of the genus <i>Schistosoma</i>. Humans become infected when larvae (cercariae) in infested freshwater penetrate the skin, potentially causing cercarial dermatitis. After a few weeks, eggs laid by the adult female worms living in blood vessels become trapped in body tissues, causing progressive organ damage due to inflammation, granuloma formation, and fibrosis. Acute schistosomiasis presents with fever, cough, headache, and urticaria, while chronic manifestations depend on the localization of the eggs and typically include abdominal pain, diarrhea, hepatosplenomegaly, blood in stool or urine, and dysuria, among others.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-1247/","orphanet_url":"https://www.orpha.net/en/disease/detail/1247","names":{"fr":{"name":"Schistosomiase","synonyms":["Bilharziose"],"definition":"Parasitose rare caractérisée par une infection par des trématodes du genre <i>Schistosoma</i>. La contamination se fait par pénétration transcutanée des larves (cercaires) lors de bains en eau douce et stagnante, ce qui peut provoquer une dermatite cercarienne. Après quelques semaines, les oeufs pondus par les vers femelles adultes vivant dans les vaisseaux sanguins sont piégés dans les tissus de l'organisme, provoquant des lésions organiques progressives dues à l'inflammation, à la formation de granulomes et à la fibrose. La schistosomiase aiguë se manifeste par une fièvre, une toux, des maux de tête et un urticaire, tandis que les formes chroniques dépendent de la localisation des oeufs et se traduisent généralement par des douleurs abdominales, une diarrhée, une hépatosplénomégalie, la présence du sang dans les selles ou les urines et une dysurie, entre autres."},"de":{"name":"Schistosomiasis","synonyms":["Bilharziose"],"definition":"Eine seltene parasitäre Krankheit, die durch eine Infektion mit Trematoden der Gattung <i>Schistosoma</i> gekennzeichnet ist. Der Mensch infiziert sich, wenn die Larven (Zerkarien) in befallenem Süßwasser in die Haut eindringen und eine Zerkariendermatitis verursachen können. Nach einigen Wochen setzen sich die von den erwachsenen weiblichen Würmern, die in Blutgefäßen leben, abgelegten Eier im Körpergewebe fest und verursachen fortschreitende Organschäden durch Entzündungen, Granulombildung und Fibrose. Akute Bilharziose äußert sich durch Fieber, Husten, Kopfschmerzen und Urtikaria, während chronische Manifestationen von der Lokalisation der Eier abhängen und typischerweise unter anderem Bauchschmerzen, Durchfall, Hepatosplenomegalie, Blut im Stuhl oder Urin und Dysurie umfassen."},"es":{"name":"Esquistosomiasis","synonyms":["Bilharziosis"],"definition":"Es una rara enfermedad parasitaria caracterizada por la infección por trematodos del género <i>Schistosoma</i>. Los seres humanos se infectan cuando las larvas (cercarias) del agua dulce infestada penetran la piel, causando potencialmente dermatitis por cercarias. Después de unas semanas, los huevos puestos por las lombrices adultas que viven en los vasos sanguíneos quedan atrapados en los tejidos del cuerpo, causando daño progresivo a los órganos debido a la inflamación, la formación de granulomas y la fibrosis. La esquistosomiasis aguda se presenta con fiebre, tos, cefalea y urticaria, mientras que las manifestaciones crónicas dependen de la localización de los huevos y típicamente incluyen dolor abdominal, diarrea, hepatoesplenomegalia, sangre en las heces u orina y disuria, entre otras."},"it":{"name":"Schistosomiasi","synonyms":["Bilharziosi"],"definition":"La schistosomiasi è una malattia infettiva causata dai trematodi, parassiti alla specie <i>Schistosoma</i> , che colonizzano i vasi sanguigni e depongono uova che causano reazioni granulomatose che esitano nella malattia acuta (prurito del nuotatore o schistosomiasi acuta) o nella malattia cronica. A seconda della localizzazione delle uova, i segni della schistosomiasi cronica comprendono la diarrea, il dolore addominale, la perdita di appetito, l'anemia (intestino), l'epatosplenismo, la fibrosi periportale associata ad ipertensione portale (fegato), l'infiammazione e la formazione di cicatrici nel tratto urogenitale, l'ematuria e la disuria (apparato genito-urinario). Alcuni pazienti sono asintomatici."},"nl":{"name":"Schistosomiase","synonyms":["Bilharzia"],"definition":"Een zeldzame parasitaire ziekte, gekenmerkt door infectie met trematoden van het geslacht <i>Schistosoma</i>. Mensen raken geïnfecteerd wanneer larven (cercariën) in besmet zoet water de huid binnendringen, en mogelijk cercariëndermatitis veroorzaken. Na enkele weken komen eieren gelegd door volwassen vrouwelijke wormen die leven in bloedvaten, vast te zitten in weefsels, waar ze progressieve orgaanschade veroorzaken door inflammatie, vorming van granuloom, en fibrose. Acute schistosomiase presenteert zich met koorts, hoest, hoofdpijn en urticaria, terwijl chronische manifestaties afhankelijk zijn van de lokalisatie van de eieren en doorgaans bestaan uit onder meer abdominale pijn, diarree, hepatosplenomegalie, bloed in ontlasting of urine, en dysurie."},"pt":{"name":"Schistosomíase","definition":"Doença parasitária rara caracterizada pela infeção por trematódos do género Schistosoma. Os humanos são infetados quando as larvas (cercárias) em água doce infestada penetram na pele, causando uma potencial dermatite cercariana. Após algumas semanas, os ovos dos parasitas fêmeas adultos que permanecem nos vasos sanguíneos ficam presos nos vários tecidos do corpo, causando danos progressivos aos órgãos devido a inflamação, formação de granuloma e fibrose. A schistosomíase aguda surge com febre, tosse, cefaleias e urticária, enquanto as manifestações crónicas dependem da localização dos ovos e incluem, geralmente, dor abdominal, diarreia, hepatoesplenomegalia, sangue nas fezes ou urina e disúria, entre outras."},"pl":{"name":"Schistosomatoza","synonyms":["Bilharcjoza"],"definition":"Rzadka choroba pasożytnicza charakteryzująca się zakażeniem przywrami z rodzaju Schistosoma. Ludzie zarażają się, gdy larwy (cerkarie) w zakażonej wodzie słodkiej wnikają w skórę, potencjalnie powodując cerkarialne zapalenie skóry. Po kilku tygodniach jaja składane przez dorosłe samice robaków bytujące w naczyniach krwionośnych zostają uwięzione w tkankach ciała, powodując postępujące uszkodzenie narządów z powodu stanu zapalnego, tworzenia się ziarniniaków i zwłóknienia. Ostra schistosomatoza objawia się gorączką, kaszlem, bólem głowy i pokrzywką, podczas gdy przewlekłe objawy zależą od lokalizacji jaj i zazwyczaj obejmują bóle brzucha, biegunkę, powiększenie wątroby i śledziony, obecność krwi w stolcu lub moczu oraz dyzurię."},"cs":{"name":"Schistosomóza","synonyms":["Bilharzióza"]},"uk":{"name":"Шистосомоз","synonyms":["Більхарциоз"],"definition":"A rare parasitic disease characterized by infection with trematodes of the genus <i>Schistosoma</i>. Humans become infected when larvae (cercariae) in infested freshwater penetrate the skin, potentially causing cercarial dermatitis. After a few weeks, eggs laid by the adult female worms living in blood vessels become trapped in body tissues, causing progressive organ damage due to inflammation, granuloma formation, and fibrosis. Acute schistosomiasis presents with fever, cough, headache, and urticaria, while chronic manifestations depend on the localization of the eggs and typically include abdominal pain, diarrhea, hepatosplenomegaly, blood in stool or urine, and dysuria, among others."},"zh":{"name":"血吸虫病","synonyms":["裂体吸虫病"]},"tr":{"name":"Şistozomiyaz","synonyms":["Bilarziyaz"]}},"xrefs":[{"source":"OMIM","code":"181460","qualifier":"BTNT","icd_relation":null,"validated":true},{"source":"ICD-10","code":"B65.0","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B65.1","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B65.2","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B65.3","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B65.8","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-10","code":"B65.9","qualifier":"BTNT","icd_relation":"specific","validated":true},{"source":"ICD-11","code":"1F86","qualifier":"E","icd_relation":"specific","validated":true,"icd11_uri":"1194562592"},{"source":"ICD-11","code":"1F86.0","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1376448576"},{"source":"ICD-11","code":"1F86.1","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"927022506"},{"source":"ICD-11","code":"1F86.2","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1139567957"},{"source":"ICD-11","code":"1F86.3","qualifier":"BTNT","icd_relation":"specific","validated":true,"icd11_uri":"1552774890"},{"source":"MONDO","code":"0015254","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"D012552","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0036323","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"9687","qualifier":"E","icd_relation":null,"validated":true},{"source":"MedDRA","code":"10039603","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":68416,"name":"Rare infectious disease"},"parents":[{"orpha":163588,"name":"Rare parasitic disease","classifications":[203]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["All ages"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Europe","status":"Not yet validated","source":"18445419[PMID]"},{"type":"Point prevalence","qualification":"Class only","class":">1 / 1000","value":0.0,"area":"Africa","status":"Not yet validated","source":"ORPHANET"}],"phenotypes":null}