{"orpha":1221,"name":"Cheilitis glandularis","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":[],"definition":"A rare skin disease of unknown origin characterized by macrocheilia and secretions of thick saliva from swollen labial minor salivary glands.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-1221/","orphanet_url":"https://www.orpha.net/en/disease/detail/1221","names":{"fr":{"name":"Chéilite glandulaire","definition":"Maladie rare de la peau d'origine inconnue caractérisée par une macrochéilie et le gonflement de glandes salivaires mineures labiales sécrétant de la salive épaisse."},"de":{"name":"Cheilitis glandularis","synonyms":["Cheilitis glandularis apostematosa","Von-Baelz-Krankheit"],"definition":"Eine seltene Hauterkrankung unbekannter Herkunft, die durch Makrocheilie und Absonderung von dickflüssigem Speichel aus geschwollenen labialen Nebenspeicheldrüsen gekennzeichnet ist."},"es":{"name":"Queilitis glandular","definition":"Es una enfermedad poco frecuente de la piel de origen desconocido caracterizada por macroqueilia y secreciones de saliva espesa por las glándulas salivales menores inflamadas."},"it":{"name":"Cheilite ghiandolare","definition":"La cheilite ghiandolare (CG) è una malattia rara della cute, caratterizzata da macrocheilia e secrezione di saliva densa dalle ghiandole salivari minori labiali che appaiono gonfie. L'eziologia non è nota."},"nl":{"name":"Cheilitis glandularis","definition":"Een zeldzame aandoening van huid met onbekende oorsprong, gekarakteriseerd door macrocheilie en secretie van dik speeksel uit gezwollen kleine labiale speekselklieren."},"pt":{"name":"Queilite glandular"},"pl":{"name":"Zapalenie gruczołowe warg"},"cs":{"name":"Glandulární cheilitida"},"uk":{"name":"Залозистий хейліт","definition":"A rare skin disease of unknown origin characterized by macrocheilia and secretions of thick saliva from swollen labial minor salivary glands."},"zh":{"name":"腺性唇炎"},"tr":{"name":"Cheilitis glandularis"}},"xrefs":[{"source":"OMIM","code":"118330","qualifier":"E","icd_relation":null,"validated":true},{"source":"ICD-10","code":"K13.0","qualifier":"NTBT","icd_relation":"inclusion","validated":true},{"source":"ICD-11","code":"DA00.0","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"524276118"},{"source":"MONDO","code":"0007313","qualifier":"E","icd_relation":null,"validated":true},{"source":"MeSH","code":"C535921","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C0267034","qualifier":"E","icd_relation":null,"validated":true},{"source":"GARD","code":"412","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":89826,"name":"Rare skin disease"},"parents":[{"orpha":90077,"name":"Other acquired skin disease","classifications":[187]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":["Not applicable"],"onset":["Adolescent","Adult","Childhood","Elderly"],"prevalence":[{"type":"Point prevalence","qualification":"Class only","class":"<1 / 1 000 000","value":0.0,"area":"Worldwide","status":"Validated","source":"ORPHANET"},{"type":"Cases/families","qualification":"Case(s)","class":null,"value":100.0,"area":"Worldwide","status":"Validated","source":"[EXPERT]"}],"phenotypes":{"validation_status":"y","online":"y","validation_date":"2016-06-01","source":null,"terms":[{"hpo":"HP:0010286","label":"Abnormal salivary gland morphology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0010978","label":"Abnormality of immune system physiology","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002664","label":"Neoplasm","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0002860","label":"Squamous cell carcinoma","frequency":"Very frequent (99-80%)","criteria":null},{"hpo":"HP:0000179","label":"Thick lower lip vermilion","frequency":"Very frequent (99-80%)","criteria":null}]}}