{"orpha":100035,"name":"Solitary necrotic nodule of the liver","type":"Disease","group":"Disorder","status":"active","flags":[],"synonyms":["Hepatic solitary necrotic nodule"],"definition":"A rare nonmalignant hepatic lesion characterized by a mass with a completely necrotic core often partially calcified, surrounded by a dense hyalinized fibrous capsule containing elastin fibers. Patients are usually asymptomatic but some may suffer from intermittent abdominal pain or discomfort.","note":null,"url":"https://raremap.alftech.space/d/ORPHA-100035/","orphanet_url":"https://www.orpha.net/en/disease/detail/100035","names":{"fr":{"name":"Nodule nécrotique solitaire du foie","definition":"Lésion hépatique rare et bénigne caractérisée par une masse avec un noyau complètement nécrosé, souvent partiellement calcifié, entouré d'une capsule fibreuse hyalinisée dense contenant des fibres d'élastine. Les patients sont généralement asymptomatiques, mais certains peuvent souffrir de douleurs abdominales intermittentes ou d'inconfort."},"de":{"name":"Lebertumor, nekrotischer solitärer","definition":"Der solitäre nekrotische Lebertumor ist eine seltene nicht-maligne Läsion der Leber. Sie ist gekennzeichnet durch eine Gewebsmasse mit vollständig nekrotischem, oft kalzifizierten Kern, der von einer dichten hyalinisierten Bindegewebskapsel mit Elastin-Fasern umgeben ist. Die meisten Patienten sind symptomfrei, einige leiden jedoch unter intermittierenden Leibschmerzen oder Unwohlsein."},"es":{"name":"Nódulo necrótico solitario del hígado","synonyms":["Nódulo necrótico solitario hepático"],"definition":"Es una lesión hepática benigna poco frecuente que se caracteriza por una masa con un núcleo completamente necrótico a menudo parcialmente calcificado, rodeado por una densa cápsula fibrosa hialinizada que contiene fibras de elastina. Los pacientes son normalmente asintomáticos pero algunos pueden sufrir de dolores abdominales intermitentes o malestar."},"it":{"name":"Tumore necrotico solitario del fegato","definition":"Il tumore necrotico solitario del fegato è una lesione epatica rara, non maligna, caratterizzata da una massa che contiene un nucleo necrotico, spesso parzialmente calcificato, circondato da una capsula fibrosa ialinizzata densa, contenente fibre di elastina. I pazienti di solito sono asintomatici, ma possono presentare dolore o fastidio addominale intermittente."},"nl":{"name":"Solitaire necrotische nodulus van lever","synonyms":["Hepatische solitaire necrotische nodulus"],"definition":"Een zeldzaam, niet-maligne leverletsel gekarakteriseerd door een massa met een volledig necrotische, vaak deels verkalkte, kern, omringd door een dens, gehyaliniseerd, fibreus kapsel dat elastinevezels bevat. Patiënten zijn meestal asymptomatisch, maar sommigen kunnen lijden aan intermitterende abdominale pijn of abdominaal ongemak."},"pt":{"name":"Tumor solitário necrótico do fígado"},"pl":{"name":"Pojedynczy martwiczy guz wątroby","synonyms":["Hepatic solitary necrotic nodule"]},"cs":{"name":"Solitární nekrotický nádor jater","synonyms":["Hepatic solitary necrotic nodule"]},"uk":{"name":"Поодинокий некротичний вузол печінки","synonyms":["Печінковий солітарний некротичний вузол"],"definition":"A rare nonmalignant hepatic lesion characterized by a mass with a completely necrotic core often partially calcified, surrounded by a dense hyalinized fibrous capsule containing elastin fibers. Patients are usually asymptomatic but some may suffer from intermittent abdominal pain or discomfort."},"zh":{"name":"肝脏孤立性坏死结节","synonyms":["肝孤立坏死性结节"],"definition":"肝脏孤立性坏死性结节是一种罕见的非恶性肝脏病变，其特征是肿块内有完全坏死的核心，常部分钙化，周围环绕着一层含有弹性蛋白纤维的致密玻璃化纤维膜。患者通常没有症状，但有些可能会出现间歇性腹痛或不适。"},"tr":{"name":"Karaciğerin soliter nekrotik nodülü","synonyms":["Hepatik soliter nekrotik nodül"]}},"xrefs":[{"source":"ICD-10","code":"K76.8","qualifier":"NTBT","icd_relation":"attributed","validated":true},{"source":"ICD-11","code":"DB99.Y","qualifier":"NTBT","icd_relation":"index","validated":true,"icd11_uri":"209168589"},{"source":"MONDO","code":"0015049","qualifier":"E","icd_relation":null,"validated":true},{"source":"UMLS","code":"C2960192","qualifier":"E","icd_relation":null,"validated":true}],"associations":[],"incoming_associations":[],"preferential_parent":{"orpha":57146,"name":"Rare hepatic disease"},"parents":[{"orpha":306636,"name":"Rare tumor of liver and intrahepatic biliary tract","classifications":[183,202]}],"children":[],"genes":[],"genes_via_subtypes":[],"inheritance":[],"onset":[],"prevalence":[],"phenotypes":null}