Gestational choriocarcinoma
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A form of gestational trophoblastic neoplasia characterized histologically by trophoblast proliferation, absence of chorionic villi (except in cases of intraplacental choriocarcinoma) and tissue necrosis with bleeding. The tumor occurs secondary to pregnancy (ectopic or normal), miscarriage, voluntary termination of pregnancy (VTP) or a hydatidiform mole. Indicative signs are persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after removal of a hydatidiform mole; persistent unexplained metrorrhagia following spontaneous abortion or VTP; occasionally unexplained metrorrhagia in the weeks or months following normal childbirth or an ectopic pregnancy. Occasionally, metastases (lung, liver, brain, kidneys, vagina) are indicative signs in women of childbearing age.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Gestational choriocarcinoma | |
| fr | Choriocarcinome gestationnel | |
| de | Chorionkarzinom, gestationales | Schwangerschafts-Chorionkarzinom |
| es | Coriocarcinoma gestacional | |
| it | Coriocarcinoma gestazionale | |
| nl | Gestationeel choriocarcinoom | Zwangerschapsgerelateerd choriocarcinoom |
| pt | Coriocarcinoma gestacional | |
| pl | Kosmówczak ciążowy | |
| cs | Gestační choriokarcinom | |
| uk | Гестаційна хоріокарцинома | |
| zh | 妊娠性绒毛膜癌 | |
| tr | Gestasyonel koryokarsinom |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C58 | NTBT | attributed | validated |
| ICD-11 | 2C75.0 | NTBT | index | validated |
| MONDO | 0020550 | E | validated | |
| UMLS | C0349557 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:99913Extragonadal non-dysgerminomatous germ cell tumor
rare neoplastic diseases; rare transplant-related disorders - ORPHA:59305Gestational trophoblastic neoplasm
rare neoplastic diseases; rare gynecological and obstetric diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
3 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
| Annual incidence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
| Lifetime Prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
6 annotations · validated 2019-06-03| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Obligate (100%) | ||
| HP:0100768 | Choriocarcinoma | Diagnostic criterion |
| Very frequent (99-80%) | ||
| HP:0011433 | High maternal serum chorionic gonadotropin | |
| HP:0100608 | Metrorrhagia | |
| HP:0002664 | Neoplasm | |
| HP:0005268 | Spontaneous abortion | |
| HP:0031502 | Trophoblastic tumor | |
Run the differential on the 6 obligate / very frequent terms
Annotation source: 23999759[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/99926
- This record as JSON: /data/d/99926.json