Acute myeloid leukemia with minimal differentiation
Synonyms: AML M0 · Minimally differentiated acute myeloblastic leukemia
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A rare subtype of acute myeloid leukemia characterized by clonal proliferation of poorly differentiated myeloid blasts in the bone marrow, blood or other tissues. It usually presents with anemia, thrombocytopenia and other nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). Low remission rates are reported.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute myeloid leukemia with minimal differentiation | AML M0 · Minimally differentiated acute myeloblastic leukemia |
| fr | Leucémie aiguë myéloblastique avec différenciation minimale | AML M0 · LAM M0 · Leucémie aiguë myéloblastique avec différenciation minime · Leucémie aiguë myéloïde avec différenciation minimale · Leucémie myéloblastique aiguë type peu différenciée |
| de | Leukämie, akute myeloische, mit minimaler Ausreifung | AML M0 |
| es | Leucemia mieloide aguda con mínima diferenciación | AML M0 · Leucemia mieloblástica aguda mínimamente diferenciada |
| it | Leucemia mieloblastica acuta leggermente differenziata | AML M0 |
| nl | Acute myeloïde leukemie met minimale differentiatie | AML M0 · Minimaal gedifferentieerde acute myeloblastische leukemie |
| pt | Leucemia mieloblástica, aguda, minimamente diferenciada | |
| pl | Ostra białaczka mieloblastyczna o minimalnym zróżnicowaniu | AML M0 · Minimalnie zróżnicowana ostra białaczka mieloblastyczna |
| cs | Akutní myeloblastická leukémie minimálně diferencovaná | AML M0 |
| uk | Гостра мієлоїдна лейкемія з мінімальною диференціацією | ГМЛ M0 · Мінімально диференційована гостра мієлобластна лейкемія |
| zh | 急性髓细胞白血病微分化型 | 微分化型急性髓系白血病 |
| tr | Minimal farklılaşma ile seyreden akut miyeloid lösemi | AML M0 · Minimal diferansiye akut miyeloblastik lösemi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C92.0 | NTBT | inclusion | validated |
| ICD-11 | 2A60.30 | E | specific | validated |
| ICD-11 | XH90G0 | E | specific | validated |
| MONDO | 0005223 | E | validated | |
| UMLS | C0522631 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:167714Unclassified acute myeloid leukemia
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders
No children.
Genes
1 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| FLT3 | Disease-causing somatic mutation(s) in | Assessed | HGNC:3765 | ENSG00000122025 | 136351 | 13q12.2 | fms related receptor tyrosine kinase 3 | 22338050[PMID] |
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | 0.01 / 100 000 | Europe | Value and class | Validated | RARECARE surveillance of rare cancers in Europe[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/98832
- This record as JSON: /data/d/98832.json