Dementia pugilistica
Synonyms: Boxer's dementia · Chronic traumatic encephalopathy · Punch-drunk syndrome
- Type
- Disease
- Group
- Disorder
- Age of onset
- Adult
- Status
- active
A rare neurologic disease characterized by progressive neurodegeneration secondary to repetitive mild traumatic brain injuries. The clinical picture is highly variable and includes behavioral or psychiatric symptoms (such as aggression, depression, delusions, and suicidality), cognitive impairment (including diminished attention, memory deficits, executive functioning deficits, and dementia), and motor deficits (including parkinsonism, ataxia, and dysarthria). Neuropathological hallmark is the accumulation of phosphorylated tau-protein in sulci and perivascular regions.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Dementia pugilistica | Boxer's dementia · Chronic traumatic encephalopathy · Punch-drunk syndrome |
| fr | Démence pugilistique | Encéphalite par trauma chronique |
| de | Dementia pugilistica | Boxer-Demenz · Enzephalopathie, chronische traumatische · Punch-Drunk-Syndrom |
| es | Demencia pugilística | Demencia del boxeador · Encefalopatía traumática crónica · Síndrome Punch-drunk |
| it | Demenza pugilistica | Demenza del pugile · Encefalopatia cronica traumatica · Sindrome "punch-drunk" |
| nl | Dementia pugilistica | Boksersdementie · Chronische traumatische encefalopathie · Punch drunk-syndroom |
| pt | Demência pugilística | Demência do pugilista |
| pl | Demencja bokserów | Demencja bokserska · Przewlekła encefalopatia urazowa · Zespół zamroczenia od uderzenia pięścią |
| cs | Dementia pugilistica | Boxerská demence · Chronická traumatická encefalopatie · Punch-drunk syndrom |
| uk | Деменція бійцівського типу | Боксерська деменція · Хронічна травматична енцефалопатія · Синдром пяного пуншу |
| zh | 拳击员痴呆 | 慢性创伤性脑病 |
| tr | Demans pugilistica | Boxer'ün demansı · Sarhoş yumruğu sendromu · Kronik travmatik ensefalopati |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | F01.8 | NTBT | attributed | validated |
| ICD-11 | 8A00.25 | NTBT | index | validated |
| MONDO | 0019976 | E | validated | |
| UMLS | C0149843 | E | validated | |
| MedDRA | 10087801 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:89043Rare dementia
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/97353
- This record as JSON: /data/d/97353.json