Pellagra
- Type
- Disease
- Group
- Disorder
- Status
- active
Pellagra is a nutritional disorder caused by a deficiency in niacin (vitamin B3) or its precursor (tryptophan) that is mainly observed in Asia and Africa where it is generally due to poor nutrition. It is characterized by dermatitis (symmetrical photodistributed erythema that may be accompanied by vesicles and bullae, and that develops into hyperkeratotic and hyperpigmented skin), gastrointestinal symptoms (diarrhea), and neuropsychiatric disorders (dementia). It can be life-threatening without a correct management.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Pellagra | |
| fr | Pellagre | |
| de | Pellagra | |
| es | Pelagra | |
| it | Pellagra | |
| nl | Pellagra | |
| pt | Pelagra | |
| pl | Pelagra | |
| cs | Pelagra | |
| uk | Пеллагра | |
| zh | 糙皮病 | |
| tr | Pelegra |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | E52 | E | specific | validated |
| ICD-11 | 5B5C.0 | E | specific | validated |
| MONDO | 0019975 | E | validated | |
| MeSH | D010383 | E | validated | |
| UMLS | C0030783 | E | validated | |
| GARD | 10014 | E | validated | |
| MedDRA | 10029400 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:90077Other acquired skin disease
rare skin diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
43 annotations · validated 2024-02-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0100497 | Vitamin B3 deficiency | |
| Frequent (79-30%) | ||
| HP:0008066 | Abnormal blistering of the skin | |
| HP:0004326 | Cachexia | |
| HP:0100825 | Cheilitis | |
| HP:0100543 | Cognitive impairment | |
| HP:0000992 | Cutaneous photosensitivity | |
| HP:0031258 | Delirium | |
| HP:0000726 | Dementia | |
| HP:0000716 | Depression | |
| HP:0000958 | Dry skin | |
| HP:0002015 | Dysphagia | |
| HP:0012378 | Fatigue | |
| HP:0005263 | Gastritis | |
| HP:0000206 | Glossitis | |
| HP:0000738 | Hallucinations | |
| HP:0002315 | Headache | |
| HP:0000962 | Hyperkeratosis | |
| HP:0007400 | Irregular hyperpigmentation | |
| HP:0000158 | Macroglossia | |
| HP:0002024 | Malabsorption | |
| HP:0004395 | Malnutrition | |
| HP:0002018 | Nausea | |
| HP:0012531 | Pain | |
| HP:0004396 | Poor appetite | |
| HP:0100753 | Schizophrenia | |
| HP:0000988 | Skin rash | |
| HP:0010280 | Stomatitis | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0032448 | Achlorhydria | |
| HP:0000739 | Anxiety | |
| HP:0002019 | Constipation | |
| HP:0002014 | Diarrhea | |
| HP:0031987 | Diminished ability to concentrate | |
| HP:0000712 | Emotional lability | |
| HP:0033505 | Livedo reticularis | |
| HP:0025300 | Malar rash | |
| HP:0001324 | Muscle weakness | |
| HP:0100653 | Optic neuritis | |
| HP:0003401 | Paresthesia | |
| HP:0000613 | Photophobia | |
| HP:0007141 | Sensorimotor neuropathy | |
| HP:0200037 | Skin vesicle | |
| HP:0002360 | Sleep abnormality | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 34882669[PMID]_33471377[PMID]_32491660[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/97352
- This record as JSON: /data/d/97352.json