Pituitary apoplexy
Synonyms: Pituitary tumor apoplexy
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare pituitary disease characterized by hemorrhagic or non-hemorrhagic necrosis of the pituitary gland. Clinical manifestations typically comprise sudden and severe headache (often with nausea and vomiting), visual disturbances (visual-field defects, loss of visual acuity), oculomotor palsies, and variable degrees of altered consciousness, ranging from lethargy to coma. Acute endocrine dysfunction may also be present, most commonly corticotropic deficiency with severe hypotension and hyponatremia as well as secondary adrenal failure, but also thyrotropic and gonadotropic deficiency.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Pituitary apoplexy | Pituitary tumor apoplexy |
| fr | Apoplexie hypophysaire | Apoplexie tumorale hypophysaire |
| de | Hypophyseninfarkt | Hypophysentumor-Infarkt |
| es | Apoplejía hipofisaria | Apoplejía hipofisaria tumoral |
| it | Apoplessia ipofisaria | |
| nl | Apoplexie van hypofyse | Hypofysetumor-apoplexie |
| pt | Apoplexia da pituitária | |
| pl | Apopleksja przysadki | = en |
| cs | Pituitární apoplexie | = en |
| uk | Апоплексія гіпофіза | Апоплексія пухлини гіпофіза |
| zh | 垂体卒中 | 垂体瘤卒中 |
| tr | Hipofiz apopleksi | Hipofiz tümörü apopleksi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | E23.6 | NTBT | index | validated |
| ICD-11 | 5A61.0 | NTBT | index | validated |
| MONDO | 0006908 | E | validated | |
| MeSH | D010899 | E | validated | |
| UMLS | C0032001 | E | validated | |
| MedDRA | 10056447 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:95502Acquired pituitary hormone deficiency
rare endocrine diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
41 annotations · validated 2017-03-20| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0030521 | Bitemporal hemianopia | |
| HP:0030907 | Thunderclap headache | |
| Frequent (79-30%) | ||
| HP:0030591 | Abnormal kinetic perimetry test | |
| HP:0030595 | Abnormal static automated perimetry test | |
| HP:0011748 | Adrenocorticotropic hormone deficiency | |
| HP:0006824 | Cranial nerve paralysis | |
| HP:0000651 | Diplopia | |
| HP:0002315 | Headache | |
| HP:0000815 | Hypergonadotropic hypogonadism | |
| HP:0000822 | Hypertension | |
| HP:0001943 | Hypoglycemia | |
| HP:0002902 | Hyponatremia | |
| HP:0002615 | Hypotension | |
| HP:0000802 | Impotence | |
| HP:0002017 | Nausea and vomiting | |
| HP:0000876 | Oligomenorrhea | |
| HP:0002893 | Pituitary adenoma | |
| HP:0008245 | Pituitary hypothyroidism | |
| HP:0008202 | Reduced circulating prolactin concentration | |
| Occasional (29-5%) | ||
| HP:0002921 | Abnormality of the cerebrospinal fluid | |
| HP:0000622 | Blurred vision | |
| HP:0001259 | Coma | |
| HP:0000824 | Decreased response to growth hormone stimulation test | |
| HP:0012378 | Fatigue | |
| HP:0001945 | Fever | |
| HP:0100829 | Galactorrhea | |
| HP:0040075 | Hypopituitarism | |
| HP:0000870 | Increased circulating prolactin concentration | |
| HP:0011499 | Mydriasis | |
| HP:0000980 | Pallor | |
| HP:0000613 | Photophobia | |
| HP:0000508 | Ptosis | |
| HP:0007663 | Reduced visual acuity | |
| Very rare (<4-1%) | ||
| HP:0002339 | Abnormal caudate nucleus morphology | |
| HP:0000863 | Central diabetes insipidus | |
| HP:0001289 | Confusion | |
| HP:0000845 | Elevated circulating growth hormone concentration | |
| HP:0001262 | Excessive daytime somnolence | |
| HP:0003118 | Increased circulating cortisol level | |
| HP:0001895 | Normochromic anemia | |
| HP:0100661 | Trigeminal neuralgia | |
Run the differential on the 2 obligate / very frequent terms
Annotation source: 26414232[PMID]_21044119[PMID]_26812964[PMID]_25859804[PMID]_2436600[PMID]_22491696[PMID]_20842779[PMID]_15879908[PMID]_12546370[PMID]_11357158[PMID]_10684913[PMID]_9596029[PMID]_7608291[PMID]_2878231[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/95613
- This record as JSON: /data/d/95613.json